E2. _Bioc_Lec1_ CarbMetaAndGlyc

Question 1 of 50

1

Select from the dropdown lists to complete the text.

Hexose are ( 6, 5, 4, 7 ) Carbon ( Carbohydrates, Proteins, Nucleic Acids, Lipids ) and are typically used for energy metabolism. Examples include ( Glucose, Fructose, Mannose, and Galactos, RIbose, Deoxyribose, NADH, and Galactos )e.

Pentose are ( 5, 4, 6, 7 ) carbon carbohydrates and are typically used in ( larger molecules, energy metabolism, plants, not humans ). Examples include ( Ribose, Deoxyribose, and NADH, Glucose, Fructose, Mannose,and Galactose ).

The difference in deoxyribose and ribose is with the ( H/OH, OH/H, N/lackthereof, Lackthereof/N, COO/CO, CO/COO ) group at the ( 2', 1', 3', 4', 5', 6' ) location. ( DNA, RNA ) is more stable than ( RNA, DNA ).

Stereoisomers- ( Alpha, Beta, Gamma, Delta ) is when the ( 1', 2', 3', 4' ) OH group is ( below, above, on the same plane as ) the ring, while ( beta, alpha, gamma, delta ) is when the ( 1, 2, 3, 4 )' OH group is ( above, below, in the same plane as ) the ring. This difference has a ( profound, minimal, undocumented/unexplored ) impact on its biological uses and enzyme binding.

( D and L, A and B, X and Y, G and M, Q and R, R and L, C and D ) sugars are enantiomers, which means they are ( mirror, identical, completely different, 90 degrees rotated ) images of each other. Most mammal sugars are in the ( D, L ) configuration, while ( L, D ) sugars are typically found in plants and microorganisms.

Explanation

Question 2 of 50

1

Polysaccharides can be used for _____________ in plants and animals

Select one of the following:

storage
structure
all of the above
none of the above

Explanation

Question 3 of 50

1

Disaccharides are used for

Select one of the following:

Storage
Structure
All of the above
None of the above

Explanation

Question 4 of 50

1

Beta Glucose linkage is typically seen in

Select one of the following:

Glycogen
Starch
Chitin
Cellulose

Explanation

Question 5 of 50

1

Chitin uses ____ as its main building block

Select one of the following:

Alpha linked glucose
Beta linked glucose
gamma linked glucose
N acetyl glucosamine (a linked)
N acetyl Glucosamine (beta linked)
N acetyl Glucosamine (gamma linked)

Explanation

Question 6 of 50

1

Glycogen uses glucose in what kind of linkage?

Select one of the following:

Alpha
Beta
Gamma
Delta
Reserve
CIS
Trans
Mirrored
Trick question, they arent linked

Explanation

Question 7 of 50

1

Disaccharides can enter the metabolic pathways with no prior modification or cleveage

Select one of the following:

True
False

Explanation

Question 8 of 50

1

Glycolysis is the breakdown of glucose into Acetyl-CoA

Select one of the following:

True
False

Explanation

Question 9 of 50

1

Fill the blank spaces to complete the text.

is converted into compounds, coupled with production.

Glycolysis occurs in cells of the body and the reaction occurs exclusively in the .

Explanation

Question 10 of 50

1

Glycolysis requires Oxygen to procede

Select one of the following:

True
False

Explanation

Question 11 of 50

1

Fill the blank spaces to complete the text.

is a sequence of reactions that convert to . This requires an investment of but produces a net of . There is one step that converts NAD to NAD.

Explanation

Question 12 of 50

1

Glycolysis is a unique reaction chain that is not linked to other biochemical pathways

Select one of the following:

True
False

Explanation

Question 13 of 50

1

glucose (6-C; Six Carbon) is broken into:

Select one of the following:

2 3-C molecules
3 2-Cmolecules
1 4-C molecule and 1 2-Cmolecule
none of the above
1 5-C molecule and 1 CO2 (1-C) molecule

Explanation

Question 14 of 50

1

ALL of the enzymes used in the glycolysis pathway are unique to the forward reaction of glycolysis to pyruvate

Select one of the following:

True
False

Explanation

Question 15 of 50

1

Phosofructokinase is NOT a rate limiting setp

Select one of the following:

True
False

Explanation

Question 16 of 50

1

The Hexokinase reaction precedes the Glucokinase reaction

Select one of the following:

True
False

Explanation

Question 17 of 50

1

GLUCOKINASE is ONLY found in the LIVER and PANCREAS
HEXOKINASE is found in ALL OTHER CELLS/TISSUES.

Select one of the following:

True
False

Explanation

Question 18 of 50

1

Outside of location, the major difference between Hexokinase and Glucokinase is the fact Glucokinase has a lower affinity for Glucose.

Select one of the following:

True
False

Explanation

Question 19 of 50

1

Hexokinase catalyzes the reaction of Glucose to Glucose 1 Phosphate

Select one of the following:

True
False

Explanation

Question 20 of 50

1

Glucose gets converted to fructose as a part of glycolysis.

Select one of the following:

True
False

Explanation

Question 21 of 50

1

Phospofructokinase catalyzes the reaction of Fructose 6 phosphate to Fructose 1,6 bisphosphate

Select one of the following:

True
False

Explanation

Question 22 of 50

1

Fill the blank spaces to complete the text.

Aldose catalyzes the reaction of into

Explanation

Question 23 of 50

1

Aldose cleave Glucose 1,6 bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3 phosphate

Select one of the following:

True
False

Explanation

Question 24 of 50

1

Dihydroxyacetone phosphate gets directly converted to 1,3 bisphosphoglycerate

Select one of the following:

True
False

Explanation

Question 25 of 50

1

NADH is produced by which enzyme, which also requires Mg as a cofactor

Select one of the following:

Hexokinase
Phospohexokinase Isomerase
Aldoase
glyceraldehyde 3 phosphate dehydrogenase

Explanation

Question 26 of 50

1

Which of the following enzymes (or their associated rxns) require Mg?

Select one or more of the following:

Hexokinase
Phosphoglucose isomerase
phosphofructosekinase
aldoase
Triosephosphate isomerase
glyceraldehyde 3 phosphate dehydrogenase
phosphoglycerate kinase
phosphoglycerate mutase
Enolase
Pyruvate Kinase

Explanation

Question 27 of 50

1

In Anaerobic conditions NADH is used with pyruvate to generate lactate

Select one of the following:

True
False

Explanation

Question 28 of 50

1

It is better to rest completely when fatigued (high lactate levels) from exercise

Select one of the following:

True
False

Explanation

Question 29 of 50

1

Fill the blank space to complete the text.

1,3 bisphosphoglycerate to 3 phosphoglycerate produces ATP via

Explanation

Question 30 of 50

1

The major regulatory points are which of the following enzymes

Select one or more of the following:

phosphofructosekinase
hexokinase (glucokinase)
pyruvate kinase
phosphoglucose isomerase
aldolase
Triosephosphate isomerase

Explanation

Question 31 of 50

1

The major regulatory points are all reversible reactions using the same enzyme.

Select one of the following:

True
False

Explanation

Question 32 of 50

1

Pyruvate kinase catalyze the forward and reverse reaction from phosphoenolpyruvate to pyruvate, and also generates one atp molecule

Select one of the following:

True
False

Explanation

Question 33 of 50

1

Which enzyme is the RATE LIMITING STEP

Select one of the following:

Phosphofructokinase
Hexokinase/Glucokinase
Pyruvate Kinase

Explanation

Question 34 of 50

1

Phosphofructokinase responds to

Select one or more of the following:

energy state (ATP as a positive regulator)
H+ concentration (lactate is a positive regulator)
Citrate s a positive regulator
Citrate as a negative regulator
energy state (ATP as a negative regulator)
H+ concentration (lactate is a negative regulator)
Insulin to glucagon ratio in blood (Fructose 2 6bisphosphate is a positive regulator)
Insulin to glucagon ratio in blood (Fructose 2 6bisphosphate is a negative regulator)

Explanation

Question 35 of 50

1

What is the effect of F-2,6-BP on phosphofructokinase activity on the graph [Velocity (Y) vs concentration of F6P (x)]

Select one of the following:

Shifts Graph Left, It is an activator
Shifts Graph Right, It is an activator
Shifts Graph Left, It is an inhibitor
Shifts Graph Right, It is an inhibitor

Explanation

Question 36 of 50

1

Fructose 2, 6 Bis Phosphate is produced by Glycolysis

Select one of the following:

True
False

Explanation

Question 37 of 50

1

Pyruvate Kinase is phosphorylated to make it more active

Select one of the following:

True
False

Explanation

Question 38 of 50

1

Phosphorlyation of PK is downregulated by low blood glucose levels.

Select one of the following:

True
False

Explanation

Question 39 of 50

1

Fill the blank spaces to complete the text.

Pyruvate is upregulated by and downregulated by and

Explanation

Question 40 of 50

1

Fill the blank spaces to complete the text.

Summary Slide!

is the conversion of to with and NAD production.

Glycolysis is critical for brain and erythrocyte and muscles.

, , and catalyze key steps in glycolysis.

catalyzed the and is by levels of .

is a site of secondary . it undergoes to make it .

Under conditions NAD is regenerated by conversion of to .

Explanation

Question 41 of 50

1

Fill the blank spaces to complete the text.

According to the video from slide 16, Glycolysis can be thought of in 3 different phases.

1) Energy (steps to )
2). Glucose (steps to )
3). Energy (steps to )

Explanation

Question 42 of 50

1

Fill the blank spaces to complete the text.

sensing is conducted by the . They require glucose via the transport protein, and its via the pathway.

Explanation

Question 43 of 50

1

The pancreas uses hexokinase not glucokinase

Select one of the following:

True
False

Explanation

Question 44 of 50

1

To sense the levels of glucose in the blood, Pancreatic Beta cells uptake glucose via GLUT2, where it is then processed into ATP (VIa glycolysis, the TCA and Phos Ox). The ATP levels rise and open and K channel which allows an influx of K, triggering membrane depolarization. This then triggers a Voltage dependent Calcium channel to close allowing an influx of Ca into the cell which triggers the release (exocytosis) of insulin filled vesicles.

Select one of the following:

True
False

Explanation

Question 45 of 50

1

A defect in the gene coding for which enzyme of glycolysis has been linked to early onset diabetes (T-2)

Select one of the following:

Hexokinase (II)
Glucokinase
Phospofructokinase
Aldolase
Pyruvate Kinase
Phosphoglycerate kinase

Explanation

Question 46 of 50

1

Just seeing food can trigger the release of insulin via the parasympathetic nervous system

Select one of the following:

True
False

Explanation

Question 47 of 50

1

Which cycle converts converts lactate back into glucose via glucoenogensis?

Select one of the following:

Cori Cycle
Krebs Cycle
Alanine Cycle
Kori Cycle
Phenlyalanine Cycle
Calvin Cycle

Explanation

Question 48 of 50

1

The alanine cycle recyles alanine produced by glucose metabolism to pyruvate and alanine. This cycle occurs exclusively in muscle cells and converts alanine back into glucose via pyruvate and gluconeogensis.

Select one of the following:

True
False

Explanation

Question 49 of 50

1

DISEASE QUESTION PLACEHOLDER

Select one of the following:

This one
not this one

Explanation

Question 50 of 50

1

Label the substrates/products, enzymes, and net reaction. Use Tags labeled with the prefix "R: " for the net reaction box in the bottom right. If the molecule is used multiple times, is the lowest suffix (ie_1) first.

{"1.95877_9.47368":[{"id":11204392,"answer":"Pyruvate","x":1.95877,"y":9.47368}],"11.6775_12.8521":[{"id":11204391,"answer":"Pyruvate Kinase","x":11.6775,"y":12.8521}],"7.47783_28.2456":[{"id":11204393,"answer":"Phosphoenolpyruvate","x":7.47783,"y":28.2456}],"22.8523_21.0526":[{"id":11204394,"answer":"Enolase","x":22.8523,"y":21.0526}],"32.5764_16.1404":[{"id":11204405,"answer":"Glucose","x":32.5764,"y":16.1404}],"20.7498_32.6316":[{"id":11204395,"answer":"2phosphoglycerate","x":20.7498,"y":32.6316}],"43.2203_9.12281":[{"id":11204406,"answer":"Hexokinase/Glucokinase","x":43.2203,"y":9.12281}],"37.307_25.0877":[{"id":11204396,"answer":"Twice","x":37.307,"y":25.0877}],"38.8839_33.1579":[{"id":11204397,"answer":"Phosphoglycerate mutase","x":38.8839,"y":33.1579}],"51.7617_17.7193":[{"id":11204407,"answer":"Glucose 6 phosphate","x":51.7617,"y":17.7193}],"39.4095_44.5614":[{"id":11204398,"answer":"3 phosphoglycerate","x":39.4095,"y":44.5614}],"61.8799_12.1053":[{"id":11204408,"answer":"phosphoglucose isomerase","x":61.8799,"y":12.1053}],"61.0915_23.8596":[{"id":11204409,"answer":"Fructose 6 phosphate","x":61.0915,"y":23.8596}],"55.5724_42.9825":[{"id":11204399,"answer":"Phosphoglycerate Kinase","x":55.5724,"y":42.9825}],"52.4187_58.0702":[{"id":11204400,"answer":"1,3 Bisphosphoglycerate","x":52.4187,"y":58.0702}],"73.8379_35.7895":[{"id":11204413,"answer":"fructose 1,6 Bisphosphate","x":73.8379,"y":35.7895}],"67.1362_47.7193":[{"id":11204401,"answer":"Glyceraldehyde 3 phosphate dehydrogenase","x":67.1362,"y":47.7193}],"81.328_23.1579":[{"id":11204411,"answer":"Phosphofructose kinase","x":81.328,"y":23.1579}],"42.5632_73.1579":[{"id":11204417,"answer":"R: Glucose","x":42.5632,"y":73.1579}],"74.4949_44.2105":[{"id":11204402,"answer":"Glyceraldehyde 3 phosphate","x":74.4949,"y":44.2105}],"41.3806_83.8596":[{"id":11204420,"answer":"R: ATP_1","x":41.3806,"y":83.8596}],"60.9601_72.6316":[{"id":11204418,"answer":"R: Pyruvate","x":60.9601,"y":72.6316}],"83.5619_51.0526":[{"id":11204404,"answer":"triosephosphate isomerase","x":83.5619,"y":51.0526}],"92.1033_42.807":[{"id":11204415,"answer":"Aldolase (FructoseBisphosphateAldolase)","x":92.1033,"y":42.807}],"58.7262_84.7368":[{"id":11204419,"answer":"R: ATP_2","x":58.7262,"y":84.7368}],"42.4318_96.1404":[{"id":11204422,"answer":"NAD+","x":42.4318,"y":96.1404}],"86.4529_60.1754":[{"id":11204403,"answer":"Dihydroxyacetone phosphate","x":86.4529,"y":60.1754}],"49.5278_95.4386":[{"id":11204423,"answer":"E-","x":49.5278,"y":95.4386}],"73.3123_95.2632":[{"id":11204424,"answer":"NADH","x":73.3123,"y":95.2632}],"86.4529_84.7368":[{"id":11204421,"answer":"R: ATP_3","x":86.4529,"y":84.7368}]}

Drag an answer into the correct orange point.

Pyruvate Kinase

Pyruvate

Phosphoenolpyruvate

Enolase

2phosphoglycerate

Twice

Phosphoglycerate mutase

3 phosphoglycerate

Phosphoglycerate Kinase

1,3 Bisphosphoglycerate

Glyceraldehyde 3 phosphate dehydrogenase

Glyceraldehyde 3 phosphate

Dihydroxyacetone phosphate

triosephosphate isomerase

Glucose

Hexokinase/Glucokinase

Glucose 6 phosphate

phosphoglucose isomerase

Fructose 6 phosphate

Phosphofructose kinase

fructose 1,6 Bisphosphate

Aldolase (FructoseBisphosphateAldolase)

R: Glucose

R: Pyruvate

R: ATP_2

R: ATP_1

R: ATP_3

NAD+

E-

NADH

	Created by Sahil Bharwani over 7 years ago

Biochem E2L1, GLYCOLYSIS. 49 is a palceholder till slides are released/

E2. _Bioc_Lec1_ CarbMetaAndGlyc

Question 1 of 50

Select from the dropdown lists to complete the text.

Explanation

Question 2 of 50

Polysaccharides can be used for _____________ in plants and animals

Select one of the following:

Explanation

Question 3 of 50

Disaccharides are used for

Select one of the following:

Explanation

Question 4 of 50

Beta Glucose linkage is typically seen in

Select one of the following:

Explanation

Question 5 of 50

Chitin uses ____ as its main building block

Select one of the following:

Explanation

Question 6 of 50

Glycogen uses glucose in what kind of linkage?

Select one of the following:

Explanation

Question 7 of 50

Disaccharides can enter the metabolic pathways with no prior modification or cleveage

Select one of the following:

Explanation

Question 8 of 50

Glycolysis is the breakdown of glucose into Acetyl-CoA

Select one of the following:

Explanation

Question 9 of 50

Fill the blank spaces to complete the text.

is converted into compounds, coupled with production. Glycolysis occurs in cells of the body and the reaction occurs exclusively in the .

Explanation

Question 10 of 50

Glycolysis requires Oxygen to procede

Select one of the following:

Explanation

Question 11 of 50

Fill the blank spaces to complete the text.

is a sequence of reactions that convert to . This requires an investment of but produces a net of . There is one step that converts NAD to NAD.

Explanation

Question 12 of 50

Glycolysis is a unique reaction chain that is not linked to other biochemical pathways

Select one of the following:

Explanation

Question 13 of 50

glucose (6-C; Six Carbon) is broken into:

Select one of the following:

Explanation

Question 14 of 50

ALL of the enzymes used in the glycolysis pathway are unique to the forward reaction of glycolysis to pyruvate

Select one of the following:

Explanation

Question 15 of 50

Phosofructokinase is NOT a rate limiting setp

Select one of the following:

Explanation

Question 16 of 50

The Hexokinase reaction precedes the Glucokinase reaction

Select one of the following:

Explanation

Question 17 of 50

GLUCOKINASE is ONLY found in the LIVER and PANCREAS HEXOKINASE is found in ALL OTHER CELLS/TISSUES.

Select one of the following:

Explanation

Question 18 of 50

Outside of location, the major difference between Hexokinase and Glucokinase is the fact Glucokinase has a lower affinity for Glucose.

Select one of the following:

Explanation

Question 19 of 50

Hexokinase catalyzes the reaction of Glucose to Glucose 1 Phosphate

Select one of the following:

Explanation

Question 20 of 50

Glucose gets converted to fructose as a part of glycolysis.

Select one of the following:

is converted into compounds, coupled with production.

Glycolysis occurs in cells of the body and the reaction occurs exclusively in the .

GLUCOKINASE is ONLY found in the LIVER and PANCREAS
HEXOKINASE is found in ALL OTHER CELLS/TISSUES.