Jon dL
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Jon dL
Created by Jon dL over 7 years ago
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PT 1

Question 1 of 37

1

The field of immunology expanded along with the development of vaccines. The first widely used vaccine was against the human disease smallpox and was developed from the

Select one of the following:

  • vaccinia virus

  • variola virus

  • monkeypox virus

  • chickenpox virus

Explanation

Question 2 of 37

1

The person who coined the term ‘chemotherapy’ and was the first to focus research efforts on the development of drugs to treat infectious disease was

Select one of the following:

  • Edward Jenner

  • Louis Pasteur

  • Paul Ehrlich

  • Alexander Fleming

Explanation

Question 3 of 37

1

A “magic bullet” drug to stop HIV replication might be

Select one of the following:

  • inhibition of nucleic synthesis by Rifamycin

  • inhibition of reverse transcriptase by Lamivudine

  • inhibition of protein synthesis by Streptomycin

  • inhibition of microtubule function by Mebendazole

Explanation

Question 4 of 37

1

What type of dendritic cell releases CCL 19 and 21 attracting B cells to the lymph nodes?

Select one of the following:

  • Dendrite

  • APC Dendritic

  • Follicular Dendritic

Explanation

Question 5 of 37

1

Which complement pathway(s) result in complement fixation?

Select one of the following:

  • Alternative

  • Lectin

  • Classical

  • All (alternative, lectin, classical)

Explanation

Question 6 of 37

1

A cell that has a differentiated Heavy (mew) chain and has not yet undergone light chain rearrangement is known as?

Select one of the following:

  • Pro-B cell

  • Pre-B cell

  • Mature B cell

  • Immature B cell

Explanation

Question 7 of 37

1

Neutrophils secrete many cytokines.

Select one of the following:

  • True
  • False

Explanation

Question 8 of 37

1

Innate immunity is required for adaptive immunity to occur.

Select one of the following:

  • True
  • False

Explanation

Question 9 of 37

1

Which of the following is not a granulocyte?

Select one of the following:

  • Eosinophil

  • Basophil

  • Monocyte

  • Neutrophil

Explanation

Question 10 of 37

1

A ‘magic bullet’ drug to control an infection with Candida albicans (thrush) or Tinea pedis (athlete’s foot) might target which of the following?

Select one of the following:

  • Ergosterol

  • 70S ribosomes

  • Peptidoglycan

Explanation

Question 11 of 37

1

Your 1st defense against infection is

Select one of the following:

  • Macrophages

  • Neutrophils

  • Skin and mucosal membranes

  • Lymphocytes

Explanation

Question 12 of 37

1

Which of the following is NOT a phagocyte?

Select one of the following:

  • Macrophage

  • Neutrophil

  • Dendritic cell

  • Natural Killer cell

Explanation

Question 13 of 37

1

I am a cell that plays an important role:
-in innate immunity
-as an antigen presenting cell
-in the initiation of adaptive immunity
I am a:

Select one of the following:

  • Basophil

  • Neutrophil

  • Dendritic cell

  • Natural Killer cell

Explanation

Question 14 of 37

1

An example of a primary lymphoid organ is:

Select one of the following:

  • Spleen

  • Appendix

  • Thymus

  • Peyer’s patch

Explanation

Question 15 of 37

1

The success of vaccination relies on development of a good memory response. Immunological memory develops during the __________ immune response and results in higher antibody titers in the __________ response:

Select one of the following:

  • Innate, primary

  • Innate, secondary

  • Adaptive, primary

  • Adaptive, secondary

Explanation

Question 16 of 37

1

What is an immediate (first) complement response of our innate immune system to bacterial infection?

Select one of the following:

  • Classical pathway

  • Lectin pathway

  • Alternative pathway

  • Garden pathway

Explanation

Question 17 of 37

1

Which complement pathway is activated by antibody?

Select one of the following:

  • Classical

  • Alternative

  • Lectin

  • All of the above

Explanation

Question 18 of 37

1

Complement activation results in:

Select one of the following:

  • Increased opsonization

  • Increased inflammatory response

  • Formation of a membrane attack complex

  • All of the above

Explanation

Question 19 of 37

1

Cells which are most important in immune surveillance for tumor cells are:

Select one of the following:

  • TH1 and TH2 cells

  • TH2 and B cells

  • TH1 and B cells

  • NK and CD8 T cells

Explanation

Question 20 of 37

1

A tumor occurring in a lymph node would be called:

Select one of the following:

  • Leukemia

  • Sarcoma

  • Lymphoma

  • Carcinoma

Explanation

Question 21 of 37

1

The Ames test allows detection of:

Select one of the following:

  • Carcinogens

  • Mutagens

  • Tumors

  • Proto-oncogenes

Explanation

Question 22 of 37

1

If an autoantibody is made against a cell-surface antigen, the autoimmune disease is considered a:

Select one of the following:

  • Type I

  • Type II

  • Type III

  • Type IV

Explanation

Question 23 of 37

1

Autoimmune diseases can be described as:

Select one of the following:

  • Over-reaction of the human systems to harmless environmental antigens.

  • Under reaction of the immune system to harmless environmental antigens.

  • Gain of tolerance to self-antigens.

  • Loss of tolerance to self-antigens.

Explanation

Question 24 of 37

1

An example of a minor histocompatibility complex antigen is:

Select one of the following:

  • XSCID

  • H-Y

  • HVGD

  • H-DR

Explanation

Question 25 of 37

1

If one wants to minimize the chance of GVHD following a hematopoietic cell transplants, one could administer the cytotoxic drug:

Select one of the following:

  • Rapamycin

  • Tacrolimus

  • Methotrexate

  • Prednisone

Explanation

Question 26 of 37

1

The main tissues affected by GVHD are:

Select one of the following:

  • Skin, liver and GI tract

  • Kidney, liver and heart

  • Skin, kidney and liver

  • Hair, kidney and skin

Explanation

Question 27 of 37

1

_____ transplants do not require extensive HLA matching, but _____ transplants do.

Select one of the following:

  • Cornea, liver

  • Heart, cornea

  • Liver, bone marrow

  • Bone marrow, cornea

Explanation

Question 28 of 37

1

A drug that inhibits IL-2 production is:

Select one of the following:

  • Azathioprine

  • Tacrolimus

  • Methotrexate

  • Prednisone

Explanation

Question 29 of 37

1

In dengue infection cross-reactive memory T cells recovered exhibited a higher affinity to variant epitopes representing serotypes of previous exposure – a phenomenon called:

Select one of the following:

  • Antibody-dependent enhancement

  • ADCC

  • Original antigenic sin

  • Immune complexes

Explanation

Question 30 of 37

1

Inflammatory cytokine _____ levels have been shown to be higher in DHF than in DF suggesting a role in vascular plasma leakage.

Select one of the following:

  • IFN-gamma, IL-2

  • TNF-alpha, IL-1

  • IL-10, IL-2

  • IL-6, IL-4

Explanation

Question 31 of 37

1

The genome of dengue virus is _____ and contains _____ genes.

Select one of the following:

  • 11 kb; 10

  • 15 kb; 20

  • 20 kb; 30

  • 25 kb; 40

Explanation

Question 32 of 37

1

Currently DHF and DSS represent _____ of total hospitalized dengue cases.

Select one of the following:

  • 1-25%

  • 10-50%

  • 2.5-40%

  • 5-220%

Explanation

Question 33 of 37

1

Dengue virus is a:

Select one of the following:

  • Filovirus

  • Flavivirus

  • Herpes virus

  • Rhinovirus

Explanation

Question 34 of 37

1

Anaphylatoxins produced by activated complement include:

Select one of the following:

  • C4b and C2a

  • C3b and C4a

  • C3a and C5a

  • C2b and C3a

Explanation

Question 35 of 37

1

Therapeutic monoclonal antibodies can affect the target cell by:

Select one of the following:

  • Inhibition of calcineurin and induction of apoptosis

  • Inhibit JAK 3 and induction of apoptosis

  • Block or down regulate surface molecules and induction of apoptosis

  • Disrupt DNA replication

Explanation

Question 36 of 37

1

When a graft is considered to have stable function, treatment is modified from:

Select one of the following:

  • Xenobiotics to biological

  • Biologicals to maintenance

  • Induction to maintenance

  • Xenobiotics to induction

Explanation

Question 37 of 37

1

Based on data presented by Andrew Read, the regimen for malaria treatment determined by the WHO actually:

Select one of the following:

  • Decreases competition by sensitive organisms allowing an increase in resistant organisms in an individual

  • Increase the number of resistant transmission-state organisms

  • Increases transmission of resistant organisms

  • All of the above

Explanation

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