Pharmaceutics I

Question 1 of 25

1

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?

Select one of the following:

1
2
3

Explanation

Question 2 of 25

1

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?

Select one of the following:

Solid state
Particle size
Molecular weight
Chemical structure

Explanation

Question 3 of 25

1

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?

Select one of the following:

To increase the solubility
To mask bitter tastes
To increase the viscosity
To decrease the viscosity
None of the above

Explanation

Question 4 of 25

1

Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?

Select one of the following:

Factor of 1/2
Factor of 2
Factor of 4

Explanation

Question 5 of 25

1

Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?

Select one of the following:

The viscosity would be infinite
The settling rate will be very high
The settling rate would be zero
The particle size would approach colloidal dimensions

Explanation

Question 6 of 25

1

The primary mechanism of altering dispersion medium properties is modification of:

Select one of the following:

Density
Viscosity
Dielectric constant

Explanation

Question 7 of 25

1

Which of the following characteristics is NOT desirable in the case of suspension dosage forms?

Select one of the following:

Flocculation with formulation of loosely bound aggregates
Flocculation with formulation of strongly bound aggregates
Formation of loose sediment

Explanation

Question 8 of 25

1

An advantage of a shear thinning formulation includes:

Select one of the following:

Ease of mixing with relatively mild shaking of the container
Lower viscosity on standing to prevent settling
Caking of needle shaped particles

Explanation

Question 9 of 25

1

Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?

Select one of the following:

Only for acute usage
Only for antibiotics
Never

Explanation

Question 10 of 25

1

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?

Select one of the following:

You can save the effort and advise the patient they must wait until you can order the
commercial dosage form
If a commercial liquid dosage form isn’t available, it may indicate a potential chemical
stability problem
If a commercial liquid dosage form isn’t available, it may indicate a potential physical
stability problem
Both B and C

Explanation

Question 11 of 25

1

Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) 2) 3).

Select one of the following:

1) Components forming at least 2 phases, 2) a component to stabilize the interface between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
1) At least one solid component 2) amphiphilic surfactant molecules, 3) adjustment to physiologic pH
1) Component forming liquid crystalline phases, 2) a component to overcome the “double layer between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
All of the above

Explanation

Question 12 of 25

1

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?

Select one of the following:

Dispersed phase tends to form aggregates of globules on standing
Aggregates of the dispersed phase may be re-dispersed by shaking
Large globules or aggregates of globules rise to the top or fall to the bottom of container forming a concentrated layer of dispersed phase
All or part of the liquid in the dispersed phase separates to form a distinct layer

Explanation

Question 13 of 25

1

Patients should virtually never be instructed to store an emulsion dosage form:

Select one of the following:

In the refrigerator
At room temperature
In the freezer

Explanation

Question 14 of 25

1

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

Select one of the following:

72 and 28% respectively
28 and 72% respectively
None of the above

Explanation

Question 15 of 25

1

A magma is a:

Select one of the following:

Two phase gel in which the gel mass does not consists of floccules of small distinct particles
One phase gel in which the gel mass consists of floccules of small distinct particles
Two phase gel in which the gel mass consist of floccules of small distinct particles

Explanation

Question 16 of 25

1

In a colloidal dispersion the particle size is:

Select one of the following:

Much smaller than typical molecule dimensions
Much larger than typical molecule dimensions
The same or smaller than typical molecule dimensions

Explanation

Question 17 of 25

1

Which of following is FALSE in case of gel formulation exhibiting syneresis?

Select one of the following:

A measurable increase in volume of Gel
A non-measurable change in the volume of Gel
A measureable decrease in volume of Gel
A and B
B and C

Explanation

Question 18 of 25

1

What is a major function of glycerin in the carboxymethylcellulose based gel formulations?

Select one of the following:

To prevent drying of Gel
Sweetner
Antioxidant

Explanation

Question 19 of 25

1

Which of following if true of aerosol used to provide an airborne mist?

Select one of the following:

Particle size >50μm
Particle size <50 μm
Particle size <1μm
None of above

Explanation

Question 20 of 25

1

A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container

Select one of the following:

True
False

Explanation

Question 21 of 25

1

Which of the following excipients should not be used in the formulation of a Carboxymethylcellulose-based gel?

Select one of the following:

Preservative
Glycerin
Alcohol
None of the above

Explanation

Question 22 of 25

1

Stability is an important consideration in the formulation of emulsions. Which of the following represents an irreversible phenomenon in terms of re-dispersion of emulsion?

Select one of the following:

Creaming
Coalescence of droplets
Flocculation
None of the above

Explanation

Question 23 of 25

1

Given that the API is soluble in water, which of the following type of emulsion is desirable to formulate?

Select one of the following:

O/W
W/O
None of the above

Explanation

Question 24 of 25

1

	Created by Jon dL about 7 years ago

Quiz on Pharmaceutics I, created by Jon dL on 07/03/2017.

Pharmaceutics I

Question 1 of 25

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the minimum number of phases present in a dispersed system?

Select one of the following:

Explanation

Question 2 of 25

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of the dispersed phase?

Select one of the following:

Explanation

Question 3 of 25

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it was insoluble?

Select one of the following:

Explanation

Question 4 of 25

Given the equation for Stoke’s law of settling below, by how much you have to increase the viscosity to offset a particle size increase of a factor of two?

Select one of the following:

Explanation

Question 5 of 25

Given a suspension with a fixed particle size distribution, what would be true if each powder particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of dispersion medium)?

Select one of the following:

Explanation

Question 6 of 25

The primary mechanism of altering dispersion medium properties is modification of:

Select one of the following:

Explanation

Question 7 of 25

Which of the following characteristics is NOT desirable in the case of suspension dosage forms?

Select one of the following:

Explanation

Question 8 of 25

An advantage of a shear thinning formulation includes:

Select one of the following:

Explanation

Question 9 of 25

Under what conditions would you compound a suspension using benzyl alcohol or propylene glycol for preemies?

Select one of the following:

Explanation

Question 10 of 25

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form. Why is it prudent to determine if a liquid dosage form is also commercially available?

Select one of the following:

Explanation

Question 11 of 25

Select the choices that correctly fill the blanks in the following statement: the three minimum requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) ____ 2)____ 3)____.

Select one of the following:

Explanation

Question 12 of 25

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically unstable?

Select one of the following:

Explanation

Question 13 of 25

Patients should virtually never be instructed to store an emulsion dosage form:

Select one of the following:

Explanation

Question 14 of 25

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

Select one of the following:

Explanation

Question 15 of 25

A magma is a:

Select one of the following:

Explanation

Question 16 of 25

In a colloidal dispersion the particle size is:

Select one of the following:

Explanation

Question 17 of 25

Which of following is FALSE in case of gel formulation exhibiting syneresis?

Select one of the following:

Explanation

Question 18 of 25

What is a major function of glycerin in the carboxymethylcellulose based gel formulations?

Select one of the following:

Explanation

Question 19 of 25

Which of following if true of aerosol used to provide an airborne mist?

Select one of the following:

Explanation

Question 20 of 25

A properly prepared pharmaceutical suspension should settle slowly and should readily re dispersed upon gentle shaking on the container

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?

Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?

Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?

Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?

Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) 2) 3).

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container