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undergraduate second year Biomedical science 2nd year (Cell Biology & Cellular Pathology) Quiz on Melanoma - NHS - Cell Biology & Cellular Pathology, created by Idont Evencare on 20/03/2017.

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Melanoma - NHS - Cell Biology & Cellular Pathology

Question 1 of 31

1

Melanocytes are

Select one or more of the following:

  • located in epidermis

  • located in dermis

  • originated from the neural crest

  • originated from adipoblasts

  • dendritic cells

  • pseudo-unipolar cells

  • place of melanin anabolism

  • place of melanin catabolism

Explanation

Question 2 of 31

1

Which of the following is the correct pathway of melanin synthesis?

Select one of the following:

  • Tyrosine (oxidaton by tyrosinase) --> di-hydroxy phenylalanine (oxidation by tyrosinase) --> melanin

  • Tyrosine (oxidaton by tyrosinase) --> di-hydroxy methylmelanin (oxidation by tyrosinase) --> melanin

  • Tyrosinase (oxidaton by tyrosine) --> di-hydroxy methyllalanine (reduction by tyrosine) --> melanin

  • Di-hydroxy methylalanine (oxidaton by tyrosinase) --> tyrosine (reduction by tyrosinase) --> melanin

  • Di-hydroxy methylalanine (oxidaton by tyrosine) --> tyrosinase (reduction by tyrosine) --> melanin

Explanation

Question 3 of 31

1

What are the three most common types of skin cancer?

Select one or more of the following:

  • malignant melanoma

  • basal cell melanoma

  • malignant basal keratoses

  • basal cell carcinoma

  • squamous cell carcinoma

  • merkel cell carcinoma

Explanation

Question 4 of 31

1

Which of the following is the commonest skin cancer

Select one of the following:

  • basal cell carcinoma

  • squamous cell carcinoma

  • malignant melanoma

Explanation

Question 5 of 31

1

Which of the following is the easiest skin cancer to treat

Select one of the following:

  • squamous cell carcinoma

  • basal cell carcinoma

  • malignant melanoma

Explanation

Question 6 of 31

1

Squamous cell carcinoma rarely metastasises.

Select one of the following:

  • True
  • False

Explanation

Question 7 of 31

1

Melanoma is the most common cancer in elderly

Select one of the following:

  • True
  • False

Explanation

Question 8 of 31

1

Melanoma metastises

Select one or more of the following:

  • very early

  • only if untreated

  • to most body sites

  • almost exclusively to joints and liver and heart only

  • commonly to lymph nodes

Explanation

Question 9 of 31

1

Melannoma is the moset rapidly increasing common cancer type

Select one of the following:

  • True
  • False

Explanation

Question 10 of 31

1

What are the predisposing factors for melanoma?

Select one or more of the following:

  • exposure to sun

  • alcohol abuse

  • DNA repair mechanism mutations

  • P16 gene

  • CDKN2A

  • PK20 gene

  • CD150C

  • dysplastic naevi

  • skin colour

  • number of pre-existing moles

Explanation

Question 11 of 31

1

The types of melanoma are

Select one or more of the following:

  • Nodular Melanoma

  • Acral lentiginous melanoma

  • Lentigo maligna melanoma

  • Superficial spreading

  • Lego malaria melanoma

  • Occular mesenchymous melanoma

  • Cranial melanoma

  • Chronic hepatocyte melanoma

Explanation

Question 12 of 31

1

ABCD rule in melanoma diagnosis stands for

Select one of the following:

  • A – aplasticity
    B – Border irregularity
    C – colour
    D – distance

  • A – asymmetry
    B – Border irregularity
    C – colour
    D – diameter

  • A – asymmetry
    B – Border integrity
    C – change in size
    D – distance

  • A – aplasticity
    B – basal cell symetry
    C – colour
    D – diameter

  • A – aplasticity
    B – Border integrity
    C – change in size
    D – distance

Explanation

Question 13 of 31

1

Initial diagnosis of melanoma is performed by

Select one of the following:

  • examination using bright light and magnification

  • histology using ziehl-neelsen stain

  • biopsy followed by ELISA

  • ELISA

  • biopsy followed by PCR

Explanation

Question 14 of 31

1

Common antibodies used in diagnosis of melanoma by immunohistochemistry include

Select one or more of the following:

  • Melan M

  • Melan A

  • HMB 45

  • S 100

  • CDK 150

  • JK 480

Explanation

Question 15 of 31

1

Diagnosis of melanoma is performed by

Select one or more of the following:

  • +/- immmunohistochemistry

  • +/- immunocytochemistry

  • special stain histology

  • H/E stain histology

  • ELISA

  • laparoscopy

Explanation

Question 16 of 31

1

Melanin does not always have to be present in melanoma

Select one of the following:

  • True
  • False

Explanation

Question 17 of 31

1

In histological examination of melanoma, which if the following are typically observed?

Select one or more of the following:

  • Prominent nucleoli

  • Missing nucleoi

  • Irregular nucleoi

  • Popcorn cells

  • Reed-Strenberg cells

  • Large cells

  • Small cells

Explanation

Question 18 of 31

1

Special stains are the most common diagnostic tool in melanomas

Select one of the following:

  • True
  • False

Explanation

Question 19 of 31

1

Melanin is a

Select one of the following:

  • big strong cookie booboo

  • strong reducing agent

  • strong oxidising agent

  • reactively inert molecule

Explanation

Question 20 of 31

1

Special stains can be used for the diagnosis of amelanotic melanomas

Select one of the following:

  • True
  • False

Explanation

Question 21 of 31

1

Immunohistochemistry can be used for the diagnosis of amelanotic melanomas

Select one of the following:

  • True
  • False

Explanation

Question 22 of 31

1

Immunocytochemistry is used in diagnosis of melanoma in

Select one or more of the following:

  • Difficult cases

  • Metastasis

  • Micro invasion

  • None of the above

  • All of the above

  • Reed-Sternberg melanoma

Explanation

Question 23 of 31

1

The target protein for S100 is , HMB45 is and Melan A is sometimes found in .

Drag and drop to complete the text.

    not specific for melanoma
    sometimes absent from melanomas
    non-melanoma tumours

Explanation

Question 24 of 31

1

Clinical staging is based on

Select one or more of the following:

  • histological staging of primary tumour

  • histological staining of metastasis

  • lymph node involvement

  • basal cell involvement

  • metastases

  • age of the patient

Explanation

Question 25 of 31

1

Breslow measures the whereas Clark measure the . Breslow method is than Clark method.

Drag and drop to complete the text.

    depth
    thickness of tumour
    levels
    depth of invasion
    more accurate
    less accurate

Explanation

Question 26 of 31

1

Clinical staging does NOT rely on the histological measurement of

Select one of the following:

  • Ulceration

  • Lymphoid infiltration

  • Mitotic activity

  • Vascular ivasion

  • Dendritic necrosis

  • Microscopic satellites

Explanation

Question 27 of 31

1

Treatment of melanoma is the same regardless of the stage

Select one of the following:

  • True
  • False

Explanation

Question 28 of 31

1

Treatment of melanoma can include the removal of

Select one or more of the following:

  • all metastases

  • sentinel lymph node/s

  • primary tumour, minimum 5mm

  • primary tumour, minimum 2mm

  • all moles

Explanation

Question 29 of 31

1

Biological therapy of melanoma often consists of

Select one of the following:

  • BRAF inhibitor drug regimes

  • Interleukin alpha inhibitor drug regime

  • Low salt and fat intake diet

  • Broad spectrum drugs

  • Localised irradiation

Explanation

Question 30 of 31

1

BRAF 600 gene is found in about half the melanoma patients

Select one of the following:

  • True
  • False

Explanation

Question 31 of 31

1

Punch skin biopsy is the only method of obtaining histological tissue for diagnosis of melanoma.

Select one of the following:

  • True
  • False

Explanation

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