Malaria

Life cycle

treatment

What has been driving malaria drug discover

Artemisinin

Mode of Action

Anticancer therapy

No longer used as a drug?

Pharmacology

Issues

Why

Ways?

Natural: Artemisia annua

Chemical: artemisin

Chemical; alternatives- synthetic peroxides

Trioxolane

Trioxolane: Arterolane maleate with piperaquine

Avoiding resistance

vote for arterolane and other drugs

Key features included low product costs
requiring a straightforward synthesis and simple formulation
approaches, a maximum 3-day treatment regimen with once-daily
administration necessitating good potency and pharmacokinetic properties, low potential for toxicity and no evidence for resistance development... Vennerstrom et al., 2004

SynriamTM

Artemisinin Resistance

Synthetic