Mer Scott
Quiz by , created more than 1 year ago

• Explain what is meant by the term “selective toxicity”. • Identify 5 bacterial cell components targeted by different classes of antibiotics. • Describe some of the mechanisms of the development of antibiotic resistance and discuss how to reduce its development. • Outline the source, mode of action, importance and factors potentially compromising the successful application of penicillin to the control of bacterial infections.

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Mer Scott
Created by Mer Scott almost 7 years ago
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L37 Antimicrobial Chemotherapy

Question 1 of 5

1

Which of these best describes selective toxicity?

Select one of the following:

  • The toxicity of a treatment of antibiotics gauged by effect on the host cells.

  • The property of antibiotics that allow them to kill microbial cells but not the host cells.

  • The property of a drug meaning they affect only some cells and not other. One which kills microbial cells but not host cells is an ideal antibiotic.

Explanation

Question 2 of 5

1

How does penicillin work?

Select one of the following:

  • It interferes with the formation of the peptidoglycan wall by inhibiting formation of cross links.

  • It mimics the enzyme which forms the polyglycopeptides preventing the NAG NAM chain from forming.

Explanation

Question 3 of 5

1

What are five ways bacteria can be targeted by microbes?

Select one or more of the following:

  • Inhibition of cell wall synthesis

  • Inhibition of protein synthesis

  • Disruption of cytoplasmic membrane

  • Inhibition of general metabolic pathway

  • Inhibition of DNA/RNA synthesis

  • Degradation of intracellular enzymes

  • Opsonisation of flagella

Explanation

Question 4 of 5

1

Antibiotic resistance will be conferred on the of an antibiotic, hence the microbe has a to evolve to resist antibiotics. An example of this is enzyme produced by some microbes, which breaks and disables the ring of penicillin.
Microbial resistance can also be passed on by gene transfer.

Drag and drop to complete the text.

    survivors
    selection pressure
    beta-lactamase
    lactam
    vertical or horizontal

Explanation

Question 5 of 5

1

Which of these is not a method to reduce the development of antibiotic resistance?

Select one of the following:

  • Decrease antibiotic utilisation

  • Combination therapy

  • Improve diagnostics

  • Identify new targets

  • Identify new antibiotics

Explanation

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