Analgesic Categories
what are the chemical mediators of pain
Inflammatory mediators
how are Eiconasoids formed
COX enzyme pathway
Prostaglandins -
what is the major prostaglandin mediating pain response?
major receptors mediation PGE2 action in nerves:
NSAIDs - a bit of background
NSAIDs- actions
NSAIDs MOA
NSAIDs COX Selectivity
inhibition of COX-1
inhibition of COX-2
COX 2 specific NSAIDs
NSAID adverse effects - brief list
NSAID GI AEs
why give misoprostol with NSAIDs
NSAIDs AEs RENAL
NSAIDs AE prolongation of bleeding
Avoiding GI problems with NSAIDs
paracetamol / acetaminophen
glutathione (phase 2)
opioids - how do they work
Opioid Receptors Effects: mu
Opioid Receptors Effects: Kappa
μ opiod receptor endogenous ligands
Opioid Receptor Effects: Delta
κ opioid receptor endogenous ligands
δ opioid receptor endogenous ligands
μ opioid receptor - location
κ opioid receptor - locations
δ opioid receptor locations
more about opioid receptors
role of endogenous opioids
Exogenous Opioid Agents - 4 categories
direct effects of opioids due to inhibition of nerve transmission
HEROIN
opioid activity is dependent on structure and addictive properties is related to their potential as pain releiver
antagonists of opioids
strong opioids
weak opioids
partial opioid agonist
codeine
fentanyl <3
methadone
route of administration maters
opioid Adverse effects - ACUTE
opioid adverse effects CHRONIC
mechanism of opioid tolerance
withdrawal from opioids
opioid DDIs
methylnatrexone
long term opioid use effect on endocrine system
opioids and osteoporosis