By Christmas 1666, the plague had died out and the quarantine was lifted. In an effort to prevent further outbreaks of the plague a burning was organised. Some people burned everything but the clothes they owned in order to destroy the plague. The quarantine was effective as the plague did not afflict anywhere else in Derbyshire. The Great Plague did have a long-term demographic effect though:

There was a sharp fall in population immediately following the end of 1666, there was a sharp rise from 1667-70, but the population was still well below 1665 levels
Mortality rate was extremely high:
- Ratio of epidemic to average burials: 10.2 from 1665-66 (Eyam)
- Ratio of epidemic to average burials: 5.9 for 47 parishes in London
- Epidemic refers to an increase, often sudden, in the number of cases of a disease above what is normally expected for the population in that area
Eyam Parish Registers highlight there was very few baptisms after 1666, most likely because there was few adults of child-bearing age
Local economy: farms were left empty, the land was uncultivated and key business and trade posts were left unfilled for years

Effectiveness of the quarantine:

The decision of the villagers to put themselves in quarantine undoubtedly prevented the plague from spreading further