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Genetics Exam 2 Material for Final

Descripción

Includes Exam 2, pre-class quizzes and in class questions.
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Pregunta 1

Pregunta
The Nobel Prive this year in Physiology or Medicine went to research on:
Respuesta
  • Lasers
  • Climate Change
  • Immunotherapy and cancer
  • Improving the welfare of children
  • Discovery of telomers

Pregunta 2

Pregunta
The max RF value between 2 genes in coupling is 0.3
Respuesta
  • True
  • False

Pregunta 3

Pregunta
Which of the following does not represent an aneuploid cell?
Respuesta
  • a triploid cell
  • a cell with trisomy
  • a cell with monosomy
  • a cell from an individual with Klinefelter syndrome
  • a cell from an individual with Jacob syndrome

Pregunta 4

Pregunta
A child with Down Syndrome could result from
Respuesta
  • non-disjunction during meiosis 2
  • non-disjunction during transcription
  • non-disjunction during translation
  • non-disjunction during meiosis 1
  • two of the above

Pregunta 5

Pregunta
Live humans can be monosomic for sex chromosomes, but not monosomic for autosomes
Respuesta
  • true
  • false

Pregunta 6

Pregunta
Use the following conditions to answer the question: A. Turner Syndrome B. Edwards syndrome C. Triple X D. Polypoidy E. None of the above The Human condition where cells have an extra autosome is called-----
Respuesta
  • A
  • B
  • C
  • D
  • E

Pregunta 7

Pregunta
Use the following conditions to answer the question: A. Turner Syndrome B. Edwards syndrome C. Triple X D. Polypoidy E. None of the above The Human condition where cells have a missing sex chromosome is -----
Respuesta
  • A
  • B
  • C
  • D
  • E

Pregunta 8

Pregunta
Use the following conditions to answer the question: A. Turner Syndrome B. Edwards syndrome C. Triple X D. Polypoidy E. None of the above This is seen in some plant cells
Respuesta
  • A
  • B
  • C
  • D
  • E

Pregunta 9

Pregunta
Guanylic acid is a -------
Respuesta
  • base
  • nucleoside
  • ribonucleotide
  • amino-acid
  • none of the above

Pregunta 10

Pregunta
What is the structure of B DNA?
Respuesta
  • Left-handed double helix
  • right-handed alpha helix
  • left handed double helix with 10 bp per turn
  • right-handed double helix
  • none of the above

Pregunta 11

Pregunta
The width of DNA is 20 Angstroms
Respuesta
  • true
  • false

Pregunta 12

Pregunta
Based on Griffith's experiment, the following would kill the mouse
Respuesta
  • heat killed IIIS bacteria and live IIR
  • heat killed IIR
  • heat killed IIR and live IIIS
  • two of the above
  • all of the answers are correct

Pregunta 13

Pregunta
Which of the following represents DNA synthesis?
Respuesta
  • n(AA) --> (AA)n
  • n(dXTP)---> (dXMP)n + nPiP
  • n(XTP)---> (XMP)n + nPiP
  • n(dXMP)---> (dXMP)n + nPiP
  • n(dXMP)---> (XTP)n + nPiP

Pregunta 14

Pregunta
Which of the following is/are True regarding DNA polymerase 1?
Respuesta
  • it has 5' to 3' polymerase activity
  • it has ligase activity
  • it has 3' to 5' exonuclease activity
  • it has telomerase activity
  • two of the above

Pregunta 15

Pregunta
Meselson and Stahl provided experimental evidence for the conservative model of replication.
Respuesta
  • True
  • False

Pregunta 16

Pregunta
Helicase-----while-----topisomerase-------
Respuesta
  • breaks phosphodiester bonds/ breaks hydrogen bonds
  • breaks hydrogen bonds/ breaks phosphodiester bonds
  • breaks peptide bonds/ breaks phosphodiester bonds
  • breaks ionic bonds/ breaks phosphodiester bonds
  • none of the above

Pregunta 17

Pregunta
Which of the following statements is/are true concerning DNA replication?
Respuesta
  • both leading and lagging strands are synthesized in a 3' to a 5' direction
  • the leading strand is synthesized in a 5' to 3' direction, the lagging strand in a 3' to 5' direction
  • both leading and laggging strands are synthesized in a 5' to 3' direction
  • DNA polymerase 2 is responsible for the bilk of the nucleotide ploymerization
  • none of the above

Pregunta 18

Pregunta
After receiving a sample of cells, you determine that the cells contain tus. What can you conclude about these cells?
Respuesta
  • they are prokaryotes
  • they might be cancer cells
  • they might be stem cells
  • they are gametes
  • B and C are possible

Pregunta 19

Pregunta
The following are TRUE regarding DNA replication in Prokaryotes and Eukaryotes
Respuesta
  • Replication is semi-conservative
  • replication is bi-directional
  • replication uses ribosomes
  • replication uses promoter sequences
  • two of the above

Pregunta 20

Pregunta
If a DNA molecule has 200 bp then it is--------long
Respuesta
  • 3.4 nm
  • 6.8 Angstroms
  • 68 nm
  • 20 nm
  • none of the above

Pregunta 21

Pregunta
According to Chargaff's rules if a DNA molecule contains 34% C, then which of the following is true?
Respuesta
  • Total pyrimidines is 50%
  • 22% are adenine
  • the four bases are present at 25%
  • the total purines is 44%

Pregunta 22

Pregunta
The origins of replication in eukaryotes are called ------ and one would expect to find------
Respuesta
  • Pribnow box/ A and T bases
  • OriC/ DnaA, DnaB and DnaC
  • Shine-Delgarno/ start codon
  • ARS/ histones
  • all of the above

Pregunta 23

Pregunta
Telomerase extends the 3' single stranded DNA overhand in replication
Respuesta
  • true
  • false

Pregunta 24

Pregunta
The difference in transcription between eukaryotes and prokaryotes are:
Respuesta
  • one uses DNA pol 1 2 and 3 and the other uses different DNA pol enzymes
  • one uses primase and the other does not
  • one uses chromatin remodeling complexes and the other does not
  • one always transbries both the sense and antisense strand of the gene while the other does not
  • all of the above

Pregunta 25

Pregunta
The core promoter in prokaryotes is called
Respuesta
  • kozak sequence
  • OriC
  • Pribnow box
  • rut sequence
  • operator sequence

Pregunta 26

Pregunta
Transcription termination in prokaryotes sometimes requires:
Respuesta
  • rho, rut and tus
  • stem loop, telomeres and Nus A
  • term sigma factor and RNA pol 2
  • RNA pol3 and specific transcription factors
  • none of the above

Pregunta 27

Pregunta
Which is the sense strand?
Image:
47455497 492385901169466 4456721150256349184 N (binary/octet-stream)
Respuesta
  • Top Stand (AB)
  • Bottom Strand (CD)
  • Both
  • neither

Pregunta 28

Pregunta
In the diagram, the following are true
Image:
47455497 492385901169466 4456721150256349184 N (binary/octet-stream)
Respuesta
  • A refers to 3'
  • C refers to 3'
  • B refers to 5'
  • D refers to 5'
  • above of the above

Pregunta 29

Pregunta
What is an example of a ribozyme?
Respuesta
  • rRNA
  • tRNA
  • intronic RNA
  • miRNA
  • all of the above

Pregunta 30

Pregunta
Enhancer sequences usually bind activators and they are transcribed
Respuesta
  • true
  • false

Pregunta 31

Pregunta
in prokaryotes the small ribosomal subunit is----while in the eukaryotes it is-----
Respuesta
  • 20S, 40S
  • 20S, 50S
  • 30S, 40S
  • 30S, 50S
  • 70S, 80S

Pregunta 32

Pregunta
Some of the rRNAs in prokaryotes are ---- while some of the rRNAs in eukaryotes are -----
Respuesta
  • 16S rRNA and 18S rRNA / 23S rRNA and 28S rRNA
  • 16S rRNA and 5S rRNA / 18S rRNA and 28S rRNA
  • 23S rRNA and 28S rRNA / 16S rRNA and 28S rRNA
  • 18S rRNA and 5S rRNA / 29S rRNA and 38S rRNA
  • none of the above

Pregunta 33

Pregunta
Some of the steps in 5' capping of mRNA involve:
Respuesta
  • removing RNA and adding GMP
  • Removing DNA and adding ATP
  • Adding DNA and transfering a methyl group
  • removing a phosphate and adding GMP
  • adding poly A

Pregunta 34

Pregunta
In eukaryotes, tRNA ------
Respuesta
  • undergoes RNA processing
  • has unusual bases
  • is transported out of the cytoplasm
  • has codon sequences
  • three of the above

Pregunta 35

Pregunta
In prokaryotic translation, the first charged tRNA enters into the ribosomal P site and carries the amino acid fmet.
Respuesta
  • true
  • false

Pregunta 36

Pregunta
Which of the following amino acids exhibits " degeneracy" in the genetic code that CAN be explained by the "Wobble Hypothesis" alone?
Image:
47322998 2191513851089690 6806953428158251008 N Li (binary/octet-stream)
Respuesta
  • Tryptophan Trp
  • Arginine Arg
  • Phenylalanine Phe
  • Glutamine Gln
  • Two of the above

Pregunta 37

Pregunta
The best description of isoaccepting tRNA molecules is
Respuesta
  • different anticodons but same amino acids
  • different codons but same amino acids
  • different anticodons and different amino acids
  • different codons and different amino acids
  • all of the above

Pregunta 38

Pregunta
Choose the following answers: A. Kozak sequence B. the A site in the ribosome C. release factors D. uncharged tRNA E. none of the answers are correct Is important in binding to 18S rRNA
Respuesta
  • A
  • B
  • C
  • D
  • E

Pregunta 39

Pregunta
Choose the following answers: A. Kozak sequence B. the A site in the ribosome C. release factors D. uncharged tRNA E. none of the answers are correct Occupies the E site in translation
Respuesta
  • A
  • B
  • C
  • D
  • E

Pregunta 40

Pregunta
A possible mechanism of action of an antibiotic could be:
Respuesta
  • inhibition of DNA pol (any greek letter)
  • inhibition of DNA gyrase
  • inhibition prokaryotic peptidyl transferase
  • inhibition of movement of RNA out to cytoplasm
  • two of the answers are correct
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