Myeloproliferative Disorders

Philadelphia Chromosome is most associated with which form of Leukaemia? [blank_start]Chronic Myeloid Leukaemia[blank_end]

Chronic Myeloid Leukaemia is fatal without stem cell/bone marrow transplantation in the chronic phase

Which of the following conditions can in some cases present as Gout?

Which of the following would describe findings fitting with a diagnosis of Chronic Myeloid Leukaemia?

[blank_start]Chronic Myeloid Leukaemia[blank_end] - Causes a drastic rise in erythrocytes, platelets, neutrophils, etc [blank_start]Acute Myeloid Leukaemia[blank_end] - Causes a drastic fall in erythrocytes, platelets, neutrophils, etc

Philadelphia Chromosome causes expression of a new gene encoding a protein kinase. Which of the following protein kinase inhibitors can be used to successfully treat Chronic Myeloid Leukaemia?

The main tyrosine kinase inhibitor used to treat chronic myeloid leukaemia is called [blank_start]Imatinib[blank_end]

A patient presents to their GP complaining of headache, fatigue and an intense itching which only ever occurs whilst in the bath or shower. Their blood results show high haemoglobin levels accompanied by erythrocytosis (increase in circulating RBCs). What is your working diagnosis? [blank_start]Polycythaemia Rubra Vera[blank_end]

The presence of a JAK2 mutation in a patient would immediately lead you to thinking of which Myeloproliferative disorder? [blank_start]Polycythaemia Rubra Vera[blank_end]

The main treatment for polycythaemia rubra vera is regular [blank_start]venesection[blank_end]

The treatment for Polycythaemia Rubra Vera is venesection until the haematocrit falls below [blank_start]0.45[blank_end]

An uncontrolled production of abnormal platelets is known as Essential [blank_start]Thrombocythaemia[blank_end]

Essential Thrombocythaemia causes excessive bleeding problems

Teardrop-shaped Red Blood Cells in the peripheral blood is characteristic of which Myeloproliferative Disorder?

Idiopathic [blank_start]Myelofibrosis[blank_end] is a condition in which the proliferation of an abnormal clone of a hematopoietic stem cell results in fibrosis, or the replacement of bone marrow with scar tissue

Myelofibrosis typically results in hepatomegaly

What is the first line treatment for essential thrombocythaemia?

Which of the following can be used as a secondary therapy for Essential Thrombocythaemia?

Chronic Haemolysis predisposes an individual to gallstones

Chronic haemolysis predisposes to gallstones as there are raised levels of [blank_start]bilirubin[blank_end] in the blood