Physio cycle 1 (part 2)

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frá s.26-52
Rani Ravnsfjall
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Rani Ravnsfjall
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Resumen del Recurso

Pregunta 1

Pregunta
Vasopressin is released when
Respuesta
  • a. increased blood pressure
  • b. increased blood volume
  • c. increased osmotic pressure of blood and cerebrospinal fluid
  • d. decreased blood volume
  • e. decreased osmotic pressure of blood and cerebrospinal fluid

Pregunta 2

Pregunta
Growth factor stimulated by
Respuesta
  • a. hyperglycemia
  • b. hypoglycemia (L-Dopa i dopamine, a-adrenergic agonists, encephalins, vasopressin, Low FFA in blood)
  • c. stress and sleep (REM)
  • d. physical excercise

Pregunta 3

Pregunta
. identify factors reducing affinity of hemoglobin for oxygen
Respuesta
  • a. acidosis (high pH)
  • b. increase concentration of 2,3 BPG in erythrocytes (+ increase pCO2)
  • c. increased temperature
  • d. decreased pH of blood

Pregunta 4

Pregunta
Water
Respuesta
  • a. has low specific heat and therefore is a good source of heat storage
  • b. it can pass easily through NA channels
  • c. good solvent because of its polarity

Pregunta 5

Pregunta
Simple diffusion:
Respuesta
  • a. protein can diffuse easily through membrane
  • b. depends on chemical gradient concentration
  • c. hydrophobic proteins cannot diffuse via membrane

Pregunta 6

Pregunta
Erythrocytes of newborn
Respuesta
  • a. contain immature hemoglobin that matures during first week after delivery
  • b. hemoglobin has higher affinity to oxygen

  • c. have small nucleus
  • d. contain less hemoglobin than mature erythrocytes

Pregunta 7

Pregunta
Agglutination of erythrocytes is in vitro phenomenon. Which of following processes may facilitate agglutination.
Respuesta
  • a. Cooling (decreasing of temp) of the in vitro preparation
  • b. Administration of immunoglobulins against human IgG (idea of indirect antiglobulin test/indirect Coombs test)
  • c. Enzymatic modification of molecules of the IgG immunoglobulins
  • d. Activation of the complete system performed by complexes antigen immunoglobulins IgM/IgG

Pregunta 8

Pregunta
In healthy humans which of the following morphological elements of peripheral blood have the shortest life span:
Respuesta
  • a. Macrophages
  • b. Thrombocytes
  • c. Hematopoietic stem cells
  • d. erythrocytes
  • e. Memory B lymphocyte

Pregunta 9

Pregunta
PCV (Packed Cell Volume) of the female is 20%. Identify right sentence concerning her case
Respuesta
  • a. Her RBC is approximately 3,5 mln/mm3
  • b. She is in state of dehydration
  • c. The client suffers because of anemia
  • d. The client is in a state of polycythemia
  • e. Her RBC is approximately 2,0 mln/mm3

Pregunta 10

Pregunta
Identify right statement concerning EPO:
Respuesta
  • a. 85% of erythrocytes comes from kidney and 15% from liver
  • b. it is synthesized in the kidney and next hydroxylated in liver in effect of hypoxia
  • c. Chemoattractant facilitates homing of blood progenitor cells in bone marrow
  • d. Bilaterally nephrectomized (removal of both kidneys) patients are able maintain proper erythropoiesis
  • e. EPO stimulates differentiation of erythrocytes from cells of Colony Forming Unit of Mixed Lineages
  • f. G-CSF and interleukins 3 stimulates differentiation of erythrocytes from Colony Forming Unit of Mixed-Lineages

Pregunta 11

Pregunta
Hematopoietic stem cells play key role in human organism. Identify right statement.
Respuesta
  • a. migrate among stem cell niches of embryo
  • b. possesses ability for self renewal, highly resistant to radio chemotherapy
  • c. HSCs are not able to differentiate into blood cells of lymphoid lineage
  • d. Migration of HSCs finishes after birth. Hematopoiesis is performed in axial skeleton + proximal parts of long bones -

Pregunta 12

Pregunta
Identify the right statement related to counting of leukocytes in hemocytometers (Such as Burker chamber):
Respuesta
  • a. Measurement of leukocytes requires previous hemolysis of erythrocytes
  • b. Fluids used for counting of leukocytes shrink erythrocytes
  • c. Fluids used for counting of leukocytes stain organelles of leukocytes
  • d. Counting of leukocytes requires previous staining of all blood cells
  • e. Hypertonic solution used for counting of leukocytes dilutes blood

Pregunta 13

Pregunta
Which of the following statements concerning sedimentation of erythrocytes are true
Respuesta
  • a. Assessment of ESR requires centrifugation of erythrocytes
  • b. Increase of globulins concentration and decrease of albumin concentration in plasma decreases aggregating ability of erythrocytes. Due to this reason ESR rises
  • c. Normal ESR in healthy adult humans is usually lower than 10 mm/hour
  • d. ESR increases during menstruation and after physical exercise

Pregunta 14

Pregunta
Which of the following statements concerning sedimentation of erythrocytes are true
Respuesta
  • Assessment of ESR requires centrifugation of erythrocytes
  • b. Increase of globulins concentration and decrease of albumin concentration in plasma increases aggregating ability of erythrocytes. Due to this reason ESR rises
  • d) ESR increases during menstruation and after physical exercise

Pregunta 15

Pregunta
Hemolysis of the normal erythrocyte can occur (find best answer):
Respuesta
  • a. in concentrated solution of urea
  • b. in isotonic solution of glucose
  • c. in distilled water
  • d. in effect of dehydration (water-loss)
  • e. in 0,5% saline

Pregunta 16

Pregunta
Which of following statement concerning erythrocytes are true:
Respuesta
  • a. RDW (red blood cell distribution width) is quantitative measure of MCV
  • b. MCV is an erythrocyte index expressing average volume of erythrocytes
  • c. C of hemoglobin in blood of healthy adult women ranges 12-16 g/dL
  • d. Standard erythrocyte due to its size + shape is not able to pass via capillaries which diameter is lower than 10 micrometer

Pregunta 17

Pregunta
Identify right statements concerning an antigen:
Respuesta
  • a. it is secreted by plasmocytes in effect of immune response
  • b. it is any substance which is able to induce specific immune-response
  • c. it is secreted by T-lymphocytes in effect of immune response
  • d. able to activate complement system when bound by APCs

Pregunta 18

Pregunta
Which of following statements may characterize basophiles of blood:
Respuesta
  • a. They have large, dark blue granules in their cytoplasm
  • b. they present antigens to immune competent cells
  • c. they account for 5-10% of all leukocytes of peripheral blood
  • d. their granules contain histamine, heparin and other chemicals involved in allergic and immune responses

Pregunta 19

Pregunta
Functions of ionized calcium in organism are:
Respuesta
  • a. it inhibits secretory processes
  • b. maintains proper functioning of cellular membrane transport
  • c. factor 4 of coagulation supports proper coagulation process
  • d. it modifies hemoglobin which reduces hemoglobin affinity for oxygen

Pregunta 20

Pregunta
Identify right statements concerning tetany:
Respuesta
  • a. high plasma of magnesium produces tetany
  • b. hypocalcemia produces tetany
  • c. tetany can be observed in people whose ventilation is depressed
  • d. tetany will be observed in people with elevated level of PTH in plasma
  • e. tetany can be observed in hyperventilating people

Pregunta 21

Pregunta
Which statement characterize IgG immunoglobulin
Respuesta
  • a. it can easily produce aggregation in standard environment of own plasma
  • b. it cannot pass through placenta
  • c. it can activate complement system
  • d. it has two antigen binding sites
  • e. it is a memory immunoglobulin

Pregunta 22

Pregunta
Which of following terms and definitions properly describes hemoglobin molecules able to perform their action in conditions in human organism:
Respuesta
  • a. methemoglobin which is a form of oxygenated hemoglobin present in lungs
  • b. carbaminohemoglobin, a form of deoxygenated hemoglobin bound by CO2
  • c. carbaminohemoglobin, a form of deoxygenated hemoglobin bound by CO
  • d. oxyhemoglobin, a form of oxygenated hemoglobin present in lungs
  • e. oxyhemoglobin, a form of oxidized hemoglobin dominating in erythrocytes of arterial blood

Pregunta 23

Pregunta
Identify factors reducing affinity of hemoglobin for oxygen in tissues
Respuesta
  • a. increases pO2 and decreases pCO2
  • b. increases concentration of 2,3 BPG in erythrocytes
  • c. decreases temp. + decreases C of glucose in hypoxic tissues
  • d. decreases pH of blood + increases-temp

Pregunta 24

Pregunta
Activated partial thromboplastin time (APTT):
Respuesta
  • a. it is prolonged in case of low plasma concentration of fibrinogen (Factor 1)
  • b. depends on processes of intrinsic pathway of coagulation
  • c. depends on platelets count
  • d. depends on state of vascular wall

Pregunta 25

Pregunta
Identify proper statement concerning plasma coagulation proteins dependent on vitamin K:
Respuesta
  • a. they can be activated by heparin. substrates for thrombin
  • b. Post-translatory modification of molecules of prothrombin factor 2 + 10 in liver depends on vitamin K
  • c. activity is inhibited by inhibitors of cyclooxygenase
  • d. They are plasma coagulation factors 1, 5, 8
  • e. They are proteolytic enzymes (serine-proteases)

Pregunta 26

Pregunta
Identity proper statements concerning plasma coagulation proteins dependent on vitamin K
Respuesta
  • a) They can be activated by heparin
  • b) They are plasma coagulation factors II, VII, IX, X.
  • c) They are plasma coagulation factors I, V, VIII, XIII
  • d) Their activity is inhibited by inhibitors of cyclooxygenase
  • e) They are plasma coagulation factors XI, XII, HMWK -
  • Their activity is inhibited by coumarin-derivatives such as dikumarol and warfarin

Pregunta 27

Pregunta
Extrinsic pathway of coagulation
Respuesta
  • a. begins with exposure of collagen + activation of factor 7+3 coagulation -
  • b. begins with liberation of tissue thromboplastin (tissue factor (3))
  • c. requires factor 12 for full activation of hemostatic process
  • d. requires calcium ions (+ PL)

Pregunta 28

Pregunta
Find right sentences concerning hemagglutinins:
Respuesta
  • a. agglutinogens are synthesized in Rh+ individuals after exposure to Rh- blood
  • b. hemagglutinins in ABO system are mostly IgM class
  • c. hemagglutinins in ABO system are inborn
  • d. in ABO system they are synthesized after immunization against antigen A + B commonly present in environment

Pregunta 29

Pregunta
Type AB individuals have genes which code for
Respuesta
  • a. the sequence of amino acids of both A and B antigens
  • b. enzyme transferase that catalyzes placement of N-acetylgalactosamine into H antige
  • c. enzyme transferase that catalyzes placement of fucose onto A antigen
  • d. enzyme transferase that catalyzes placement of N-acetylgalactosamine onto D antige
  • e. enzyme transferase that catalyzes placement of D-galactose onto H antigen

Pregunta 30

Pregunta
A pregnant woman comes in for a visit. She is AB Rh-, her husband A Rh+. This is her first child. The indirect antiglobulin test is negative. What should be done at the time of the first visit
Respuesta
  • nothing
  • a. nothing b. administration of anti D-immunoglobulin to the mother at this time
  • c. administration of anti D-immunoglobulin to the mother after delivery
  • d. administration of anti D-immunoglobulin to the child if the child is Rh+

Pregunta 31

Pregunta
A couple requests blood typing of their child (father AB, mother B). Child erythrocytes are agglutinated by antigen B immunoglobulin, not agglutination by anti A or anti D) Child serum agglutinates A typed erythrocytes, does not agglutinate B typed erythrocytes. Which of following conclusions concerning child's blood type and child´s parentage:
Respuesta
  • a. the child is the natural offspring of this couple
  • b. the mother is natural, the father is not the natural father
  • c. the father is natural, the mother is not the natural mother
  • d. blood type in ABO-system is A
  • e. blood type in ABO-system is B
  • f. blood type in ABO-system is AB
  • g. child is Rh-
  • h. child is Rh+

Pregunta 32

Pregunta
Analyze ABO system of a couple: a woman (blood type A) has a father whose blood type is O, and is married to a man whose blood type is B (his mother type is O). What is their child probability of blood type A:
Respuesta
  • a. 0 %
  • b. 25 %
  • c. 50 %
  • d. 75 %

Pregunta 33

Pregunta
Which of following statements about Vasopressin are right?
Respuesta
  • a. increases salt and water reabsorption in distal tubule
  • b. increases water reabsorption by insertion of protein of AQP2 in distal part of nephron
  • c. synthesized in posterior pituitary gland
  • d. produces vasoconstriction. Action is mediated receptors coupled with phospholipase C (PLC)

Pregunta 34

Pregunta
Growth hormone (GH)
Respuesta
  • a. Acts through receptor related to Janus kinase
  • b. Is a water soluble amine hormone
  • c. Is intensively liberated during NREM sleep
  • d. Elevates plasma level of glucose (+ FFA)
  • e. liberated from posterior pituitary gland

Pregunta 35

Pregunta
Oxytocin
Respuesta
  • a. produces contraction of myoepithelial cells of the female breast
  • b. increase secretion of prolactin (gonadotropins + thyrotropin)
  • c. it’s secretion is elevated by progesterone
  • d. is produces in paraventricular nucleus of hypothalamus
  • e. decreases contraction in vas deferens in males

Pregunta 36

Pregunta
inotropic receptor producing IPSP
Respuesta
  • a. muscarinic receptor
  • b. glycine receptor
  • c. nicotine receptor
  • d. GABAa receptor
  • e. Receptor with tyrosine kinase activity

Pregunta 37

Pregunta
Extracellular fluid (ECF)
Respuesta
  • a. Is approximately 20% of total body
  • b. is approximately 20% of body mass
  • c. its volume can be tested by intravenous infusion of insulin
  • d. its main cation is MG2+

Pregunta 38

Pregunta
Find features that characterize Ryanodine Receptors
Respuesta
  • A. They are Ca2+ channels in T-tubules
  • B. They are Ca2+ channels present in Sarcoplasmic Reticulum
  • C. They are Ca2+ pumps
  • D. They are gated by Ca2+
  • E. They are gated by IP3

Pregunta 39

Pregunta
Which of these sentences regarding Extra-cellular Fluid is true?
Respuesta
  • A. Main cation is Na+
  • B. Main cation is K+
  • C. Stands for 1/3 of the TBW
  • D. Stands for ~20% of Total Body Water

Pregunta 40

Pregunta
ECF is made up of which fluid compartments?
Respuesta
  • Blood plasma
  • Interstitial fluid
  • Intercellular fluid
  • Transitional fluid

Pregunta 41

Pregunta
Fast EPSP is due to
Respuesta
  • a. N-cholinergic receptor
  • b. M-cholinergic receptor
  • c. GnRH ls ESPS
  • d. D2-receptor is IPSP

Pregunta 42

Pregunta
TBW
Respuesta
  • decreases with age
  • increases with age
  • most in men
  • TBW is 45/65 % of the body mass

Pregunta 43

Pregunta
GABA is
Respuesta
  • a. Voltage gated Cl- channel
  • b. Cl- channel, gated with GABA
  • c. Activation leads to IPSP

Pregunta 44

Pregunta
R- receptor (ryanodine receptor?)
Respuesta
  • Metabotropic receptor
  • Gated by Ca2+
  • Na+/Ca2+ exchanger

Pregunta 45

Pregunta
Receptors with tyrosine kinase
Respuesta
  • a. Muscarinic
  • b. EPO
  • c. insulin
  • d. growth hormone

Pregunta 46

Pregunta
Ionotropic receptors – which receptors belongs to this group?
Respuesta
  • • Nicotinic – Na+ (EC) (binds acetylcholine)
  • • GABAa – Cl- (EC)
  • • glycine – Cl- (EC)
  • • IP3 - Ca2+ (IC)
  • • Ryanodine - Ca2+ (IC)
  • • Cyclic nucleotide-gated ion channels- ligand cGMP, cAMP, cGTP (Na+, K+)- (IC)
  • • Intracellular ATP receptors - K+ (IC)

Pregunta 47

Pregunta
Which of the following statements concerning ionotropic receptors are true?
Respuesta
  • a. They are membrane receptors that open after binding their agonist ligand
  • b. examples are: nicotinic receptor and IP3 receptor
  • c. examples are muscarinic receptor + insulin receptor
  • d. they are located in cellular nucleus

Pregunta 48

Pregunta
Which of the following statements are related to nicotinic receptors?
Respuesta
  • a. Activation of nicotinic receptor produces IPSP of postsynaptic neuron
  • b. activation of nicotinic receptor produces EPSP of presynaptic knob
  • c. it is chemically gated sodium channel (Na)
  • d. nicotinic receptors activated by GABA
  • e. Acetylcholine is a natural gated ligand for the nicotinic receptor

Pregunta 49

Pregunta
Which of the following statements concerning intracellular fluid are true?
Respuesta
  • a. ICF is approximately 20% of Body mass
  • b. ICF is app. 2/3 of the TBW in healthy, non obese humans.
  • c. its main anion is bicarbonate HCO3
  • d. its main kation is K+
  • e. volume of ICF can be tested by intravenous infusion of insulin

Pregunta 50

Pregunta
Identify basic principles concerning counting of leukocytes:
Respuesta
  • a. hypertonic solution used for counting of leukocytes dilutes blood
  • b. counting of leukocytes requires previous hemolysis of erythrocytes
  • d. fluid usually used for assessment of WBC shrinks erythrocytes
  • e. fluid usually used for assessment of WBC stains organelles of leukocytes

Pregunta 51

Pregunta
In AB0 system:
Respuesta
  • a. Agglutinins are present in plasma of adults
  • b. Agglutinins are inherited proteins located on membranes of erythrocytes
  • c. Agglutinogens are present in plasma of neonates (newborns)
  • d. Antigens of the AB0 are found in various tissues

Pregunta 52

Pregunta
Hemolysis of normal erys occurs:
Respuesta
  • a. in effect of action of strong inorganic acids in organic solvents
  • b. in temperature higher than 60 °C
  • c. in 5% solution of Glucose -
  • d. in distilled water
  • e. in 0,6 saline

Pregunta 53

Pregunta
Choose the correct statements concerning B-lymphocytes:
Respuesta
  • a. these cells play role in cellular immunity
  • b. they mediate humoral immunity
  • c. they develop entirely in bone marrow
  • d. in effect of antigenic stimulation they form plasma cells which secrete immunoglobulins

Pregunta 54

Pregunta
Choose correct sequence of the following processes involved in inflammatory response: (ANSWER IN EXPLANATION)
Respuesta
  • a. chemotaxis
  • b. rolling
  • c. diapedesis
  • d. adhesion

Pregunta 55

Pregunta
Match properly in pairs: (answer in explanation)
Respuesta
  • Isovolemia
  • Isohydria
  • Isotonia

Pregunta 56

Pregunta
Which of following statements concerning simple diffusion via cellular membrane are true?
Respuesta
  • a. it depends on the ability of the molecule to dissolve in lipids
  • b. it depends on the chemical gradient
  • c. its rate of diffusion is directly proportional to surface area and inversely proportional to molecular size and thickness of membrane
  • d. requires special carrier proteins

Pregunta 57

Pregunta
Thrombin dependant (hydrolyzed by thrombin) coagulation factors are:
Respuesta
  • a. Factor 2 (Prothrombin)
  • b. Fibrinogen
  • c. Factors 4,5,8,13
  • d. Factor 8 (fibrin stabilizing factor)
  • e. high molecular weight kininogen (HmWK)

Pregunta 58

Pregunta
Identify right statements concerning Prothrombin time – in vitro laboratory time of coagulation:
Respuesta
  • a. is prolonged in treatment with antivitamin K (and diseases of liver)
  • b. depends on processes of intrinsic pathway of coagulation
  • c. depends on processes of extrinsic pathway
  • d. depends on platelets count (number of platelets)
  • e. depends on state of vascular endothelium

Pregunta 59

Pregunta
Affinity of hemoglobin for oxygen increases in case of:
Respuesta
  • a. decreasing PO2 in plasma (hypoxia)
  • b. decreasing PH in Plasma (acidosis)
  • c. decreasing PCO2 in plasma
  • d. decrease in temperature
  • e. increasing PH in plasma (alkalosis)

Pregunta 60

Pregunta
Which of the following statements are true in case of Erythropoietin (EPO)?
Respuesta
  • a. a glycoprotein which controls production of erythrocytes
  • b. it is made mostly in liver
  • c. hypoxia is the main stimulus for EPO release
  • d. Adenosine antagonist stimulates secretion of EPO

Pregunta 61

Pregunta
Identify right statements concerning receptors for hormones:
Respuesta
  • a. Angiotensin AT1 – receptor is coupled with phospholipase C
  • b. Receptors coupled with Gs protein activate phosphodiesterase (PDE)
  • c. Epinephrine produces its intracellular effect decreasing of adenylyl cyclase
  • d. receptors for thyroid hormones are placed in plasma membrane
  • e. receptors for sex hormones possess DNA binding domains, there are transcription factors

Pregunta 62

Pregunta
Ionotropic receptor producing IPSP is:
Respuesta
  • a. Muscarinic receptor
  • b. Glycine receptor
  • c. Nicotinic receptor -
  • d. GABA-A receptor
  • e. Receptor with tyrosine kinase activity

Pregunta 63

Pregunta
Growth hormone (GH)
Respuesta
  • a. acts through receptor related to Janus kinase
  • b. Is a water soluble amine hormone
  • c. is intensively liberated during NREM sleep
  • d. Elevates plasma level of glucose
  • e. is liberated from posterior pituitary gland

Pregunta 64

Pregunta
Oxytocin
Respuesta
  • a. produces contractions of myoepithelial cells of female breast
  • b. increases secretion of prolactin
  • c. secretion is elevated by the progesterone
  • d. Is produced in paraventricular nucleus of hypothalamus
  • e. Decreases contraction in vas deferens in males

Pregunta 65

Pregunta
Functions of ionized calcium in organism are:
Respuesta
  • a. It maintains proper functioning of neurons and myocytes
  • b. It maintains proper functioning of membranes (trans-membrane transport)
  • c. It is factor II of coagulation, supporting proper coagulation process
  • d. It binds hemoglobin, reducing hemoglobin affinity to oxygen

Pregunta 66

Pregunta
Choose the correct statement concerning chemotaxis:
Respuesta
  • a. movement/passage of blood cells, especially leukocytes, via intact capillary wall into interstitial space inflamed area
  • b. it is the movement of neutrophils and macrophages toward the source of some particular chemical substance.
  • c. It is a process which Is performed down concentration gradient of a chemotactic substance
  • d. It may be caused by the bacterial and viral toxins, degenerative products of the inflamed tissues and lymphokines.

Pregunta 67

Pregunta
Oxytocin:
Respuesta
  • a. produces contractions of myoepithelial cells of the female breast
  • b. is produced in the medulla oblongata
  • c. is liberated in effect of stimulation of mechanoreceptors in the uterine cervix
  • d. Produces relaxation of smooth muscle cells of most of vessels

Pregunta 68

Pregunta
Which of the following are NOT secreted by the anterior pituitary gland?
Respuesta
  • a. Vasopressin, Calcitonin
  • b. GH, TSH
  • c. TRH,PIH parathyroid hormone
  • d. Prolactin, gonadotropins

Pregunta 69

Pregunta
In neuromuscular junction you can find:
Respuesta
  • a. N-Cholinergic receptor
  • b. Acetylcholine receptor
  • c. B-Adrenergic receptor
  • d. Folds of cardiac membrane

Pregunta 70

Pregunta
Factors that stimulate growth hormone (GH, somatotropin) release are:
Respuesta
  • a. GnRH liberated from hypothalamus
  • b. Hyperglycemia
  • c. Decreased concentration of free fatty acids and glucose in plasma
  • d. Physical exercise

Pregunta 71

Pregunta
The following actions produces by vitamin D3
Respuesta
  • a. Stimulated synthesis of calcitonin in intestine -
  • b. increases number and activity of osteoclasts and osteoblasts
  • c. ---ocytes, it up-regulates activity of cytosolic enzymes of and increases concentration of calcium binding…rising absorption of calcium ion from the lumen of intestine
  • d. Increases reabsorption of calcium and phosphate in kidney

Pregunta 72

Pregunta
Find right sentences concerning erythrocytes sedimentation rate (ESR):
Respuesta
  • a. It is proportionate to plasma concentration of globulins
  • b. It should not exceed 15 mm/h in healthy adults. It is much higher in infectious diseases and cancer
  • c. It is a ratio of volume of all erythrocytes to the volume of whole blood
  • d. It decreases after heavy meals and physical exercise

Pregunta 73

Pregunta
Find proper sentences concerning transportation of CO2 in blood:
Respuesta
  • a. Only 5-7% of CO2 is transported in dissolved form in blood
  • b. More than 70% of CO2 is converted in bicarbonate in plasma of blood
  • c. Bicarbonate is formed from carbonic acid. Reaction is catalyzed by carbonic anhydrase of erythrocytes
  • d. Part of CO2 is reversibly bound to hemoglobin, forming carboxy- and methemoglobin
  • e. Carbaminohemoglobin is an example of reduced hemoglobin of red-brown colour

Pregunta 74

Pregunta
Low level of PCV may result from:
Respuesta
  • a. Hemorrhage
  • b. Anemia
  • c. Dehydration
  • d. Repetitive exercise

Pregunta 75

Pregunta
Identify statements characteristic for “0” typed individuals in AB0 system:
Respuesta
  • a. They have gene/genes coding for the sequence amino acids of fucosyltransferase
  • b. They have no antigens on membranes of erythrocytes
  • c. Both anti-A and anti-B immunoglobulins are synthesized after exposition to those antigens
  • d. Both anti-A and anti-B hemagglutinins are present in their plasma since their birth

Pregunta 76

Pregunta
Identify right statements concerning the clotting time:
Respuesta
  • a. It is prolonged in people treated with heparin (afibrinogenemia, factors 2,5,9,10,11,12)
  • b. It depends in the number of platelets
  • c. It tests processes of intrinsic pathway of coagulation
  • d. It depends on the state of the vascular wall

Pregunta 77

Pregunta
Primary Hemostasis:
Respuesta
  • a. Depend on the equilibrium between plasma coagulation proteins and blood vessel
  • b. It tested by clotting time and APTT
  • c. Is tested by bleeding time
  • d. Is prolonged in individuals treated with inhibitors of cyclooxygenases (aspirin)

Pregunta 78

Pregunta
Identify factors dealing with Vasopressin release:
Respuesta
  • A. Increased Osmotic Pressure, Blood and Cerebrospinal Fluid
  • B. Increased Blood Volume
  • C. Decreased Osmotic Pressure, Blood and Cerebrospinal Fluid
  • D. Decreased Blood Volume
  • E. Increased Blood Pressure

Pregunta 79

Pregunta
Phenomenon of increased liberation of renin
Respuesta
  • a. increased arterial pressure
  • b. hypoperfusion of kidney
  • c. decreased Nacl in the area of the macula densa
  • d. Activation of sympathetic system

Pregunta 80

Pregunta
Identify statements related to Türk ́s solution used in hemocytometer (counting of blood cells):
Respuesta
  • a. It produces hemolysis of erythrocytes.
  • b. It shrinks erythrocytes
  • c. It stains organelles of leukocytes.
  • d. It stains erythrocytes.
  • e. It dilutes blood.

Pregunta 81

Pregunta
Tetany can be observed in:
Respuesta
  • a. Low plasma level of magnesium.
  • b. High plasma level of calcium
  • c. High plasma level of calcium. And H^+
  • d. Acidosis (low pH)
  • e. Alkalosis (high pH)

Pregunta 82

Pregunta
Hypercalcemic hormones (elevating calcium level in plasma) are:
Respuesta
  • a. PTH.
  • b. Calcitonin.
  • c. Glucocorticoids
  • d. Vitamin 1,25 (OH)2 D3 + thyroid hormones, GH

Pregunta 83

Pregunta
Identify forms of CO2 transported in blood
Respuesta
  • a. Carbaminians and carbaminohemoglobin.
  • b. Dissolved state.
  • c. Bicarbonate.
  • d. Carboxyhemoglobin

Pregunta 84

Pregunta
Erythrocyte sedimentation rate (ESR):
Respuesta
  • a) Is a part of the blood volume that is occupied by erythrocytes
  • b) Increases with increasing concentration of plasma globulins. (ratio of albumin/globulin)
  • c) Is proportionate to RBC (number of erythrocytes in blood)
  • d) Increases with decreasing volume of erythrocytes (MCV).

Pregunta 85

Pregunta
In ABO system
Respuesta
  • a) Agglutinin are inherited proteins located on membranes of erythrocytes.
  • b) Agglutinins are present in plasma of neonates (newborn)
  • c) Antigens are found in various tissues in addition to blood.
  • d) Agglutinins are present in plasma of adults.

Pregunta 86

Pregunta
Identify statements characteristic for 0 type individuals:
Respuesta
  • a. Antigens H are present on erythrocytes.
  • b. Antigens A are present on erythrocytes.
  • c). Antigens B are present on erythrocytes.
  • d) Both anti-A and anti-B hemagglutinines are present in plasma.

Pregunta 87

Pregunta
In Rh system of blood:
Respuesta
  • a) D antigen is the most antigenic (strongest) component of the system.
  • b) D antigen is the only antigen of the system
  • c) Antigens are proteins located only on membranes of erythrocytes.
  • d) Agglutinogens are synthesized in Rh-positive individuals after exposure to Rh-negative blood.

Pregunta 88

Pregunta
Which statements characterize MHC-II proteins?
Respuesta
  • They are found on all nucleated cells, dendritic, macrophages, b-lymphocytes
  • b) They are found on antigen presenting cells
  • c) They are bound by cytotoxic T-lymphocytes
  • d) They are bound by helper T-lymphocytes

Pregunta 89

Pregunta
Main action of complement components are:
Respuesta
  • a) Damage of the cellular membrane followed by cellular lysis.
  • b) Increase of the vascular permeability and smooth muscle contraction
  • c) Chemotaxis and chemokinesis of the macrophages and neutrophils.
  • d) Phagocytosis performed by NK-cells
  • e) Degranulation of mast cells and basophils
  • f) Opsonization (facilitate phagocytosis)

Pregunta 90

Pregunta
Cells of the peripheral blood able to perform phagocytosis are:
Respuesta
  • a) Lymphocytes
  • b) Neutrophils
  • c) Basophils
  • d) Eosinophils
  • e) Megakarocytes

Pregunta 91

Pregunta
So called passive immunity develops after:
Respuesta
  • a) Invasion of a pathogen and development of the disease
  • b) Vaccination with separated antigens of microbes
  • c) Passage of maternal immunoglobulins through placenta, with milk or colostrum
  • d) Parenteral administration of the ready-made immunoglobulins

Pregunta 92

Pregunta
So called contact factors of coagulation are
Respuesta
  • a. Plasma coagulation factors II, VII, IX, X, C-protein, S protein
  • b. Plasma coagulation factors I, V, VIII, XIII
  • c. HMWK, prekallikrein
  • d. Plasma coagulation factors XI, XII

Pregunta 93

Pregunta
Primary hemostasis is composed of
Respuesta
  • a. Activation of plasma coagulation factors X, II and I
  • b. Agglutination and coagulation of platelets
  • c. Contraction of the damaged vessel
  • d. Adhesion, activation, aggregation and granulation of platelets

Pregunta 94

Pregunta
Extrinsic pathway of coagulation
Respuesta
  • a. Begins with exposure of collagen + activation of factor XII of coagulation
  • b. Begins with liberation of tissue thromboplastin (tissue factor)
  • c. Runs faster than intrinsic pathway
  • d. Requires calcium ions

Pregunta 95

Pregunta
Anti-inflammatory action of glucocorticoids are
Respuesta
  • a. They inhibit penetration of plasma proteins and inflammatory mediators through the vessel wall
  • b. They decrease the number of basophils, eosinophils, and lymphocytes
  • c. They decrease the number of neutrophils
  • d. All answers are wrong.

Pregunta 96

Pregunta
What are the main functions of SDF-1 in human hematopoiesis?
Respuesta
  • a. It is a stem cell homing factors involved in the movement of hematopoietic cells from........... hematopoiesis) -
  • b. It is a hematopoietic factor that acts at different stages of stem cell differentiation
  • c. This protein mostly regulates proliferation of stem and progenitor cells during.....??!
  • d. This factor enables the homing of transfused stem cells in the bone marrow..
  • e. Specifically interacts with superficial stem cell receptor – CXCRA

Pregunta 97

Pregunta
Hypocalcemic hormones (decreasing calcium level in plasma) are:
Respuesta
  • a. PTH
  • b. Calcitonin
  • c. Glucocorticoid Steroids
  • c. Glucocorticoid Steroids.
  • d. Vitamin 1,25 (OH)2 D3 + thyroid hormones, GH

Pregunta 98

Pregunta
Tetany can be observed in:
Respuesta
  • a. Low plasma level of potassium
  • b. High plasma level of potassium.
  • c. High plasma level of HCO3^-
  • d. Acidosis
  • e) High plasma level of HPO4^-.

Pregunta 99

Pregunta
So called active immunity develops after
Respuesta
  • a. After natural invasion of a pathogen and development of the response
  • b. Vaccination with separated antigens of microbes
  • c. Parenteral administration of ready-made immunoglobulins
  • d. Passage of maternal immunoglobulins via placenta, with milk or colostrum

Pregunta 100

Pregunta
Identify statements related to Hayem’s solution used in hemocytometer (counting of blood cells):
Respuesta
  • a. It produces hemolysis of erythrocytes.
  • b. It shrinks erythrocytes.
  • c. It stains organelles of leukocytes
  • d. It stains erythrocytes.
  • e. It dilutes blood.

Pregunta 101

Pregunta
Which of the following statements concerning water in human organism are true:
Respuesta
  • a. Water characterises with extremely high specific heat
  • b. It is a natural solvent and environment for all physiological and chemical processes occurring in human organism
  • c. Aldosterone directly increases water reabsorption in collecting duct
  • d. Main cation of intracellular water compartment is magnesium, main anion dicarbonate

Pregunta 102

Pregunta
Identify right statements concerning Total Body Water (TBW)
Respuesta
  • a. Its volume can’t be assessed by intravenous injection of inulin or other colloid molecule -
  • b. Majority of water of TBW fills extracellular compartment of organism
  • c. It is usually 60% of the body weight of the young adult human and it tends to decrease with age
  • d. Water can easily pass through cellular membrane via common to all cells water channel – aquaporin AQP1

Pregunta 103

Pregunta
Factors that stimulate growth hormone (GH, somatotropin) release are:
Respuesta
  • a. GnRH liberated from hypothalamus
  • b. Hyperglycemia
  • c. Decreased concentration of free fatty acids and glucose in plasma (Hypoglycemia)
  • d. Physical exercise - sleep, Dopamines

Pregunta 104

Pregunta
Which of the following statement concerning oxytocin are true:
Respuesta
  • a. Peptide hormone synthesized in anterior pituitary gland
  • b. Its liberation is inhibited by stimulation of mechanoreceptors located in cervix of the uterus
  • c. Responsible for milk ejection in effect of contraction of myoepithelial cells
  • d. Produces contraction of smooth muscle cells of the pregnant and non-pregnant uterus

Pregunta 105

Pregunta
Which of the following statements concerning affinity of hemoglobin for oxygen are true:
Respuesta
  • a. Affinity is inversely proportional to pH
  • b. Affinity is proportionate to the body temperature
  • c. Product of glycolysis in erythrocytes – 2,3 BPG decreases affinity of hemoglobulin for oxygen
  • d. High partial pressure of carbon dioxide – pCO2in plasma decreases affinity of hemoglobin for oxygen

Pregunta 106

Pregunta
Find right sentences concerning erythrocytes sedimentation rate (ESR):
Respuesta
  • a. It is proportionate to plasma concentration of globulins
  • b. It should not exceed 15 mm/h in healthy adults. It is much higher in infectious diseases and cancer
  • c. It is a ratio of volume of all erythrocytes to the volume of the whole blood
  • d. It decreases after heavy meals and physical exercise

Pregunta 107

Pregunta
Find proper sentences concerning transportation of CO2 in blood:
Respuesta
  • a. Only 5-7% of CO2 is transported in dissolved from in blood
  • b. More than 70% of CO2 is converted in bicarbonate in plasma of blood
  • c. Bicarbonate is formed from carbonic acid. Reaction is catalyzed by carbonic anhydrase of erythrocytes
  • d. Part of CO2 is reversibly bound to hemoglobin, forming carboxy- and methemoglobin
  • e. Carbaminohemoglobin is an example of reduced hemoglobin of red-brown colour

Pregunta 108

Pregunta
Low level of PCV may result from:
Respuesta
  • a. Hemorrhage (rapid loss of blood cells)
  • b. Anemia (loss of RBC)
  • c. Dehydration
  • d. Repetitive exercise

Pregunta 109

Pregunta
Identify statements characteristic for “0” typed individuals in AB0 system:
Respuesta
  • a. They have gene/genes coding for the sequence amino acids of fucosyl-transferase
  • b. They have no antigens on membranes of erythrocytes -
  • c. Both anti-A and anti-B immunoglobulins are synthesized after exposition to those antigens
  • d. Both anti-A and anti-B hemagglutinins are present in their plasma since their birth

Pregunta 110

Pregunta
Find solutions able to produce hemolysis to normal erythrocytes:
Respuesta
  • a. Hypertonic solution of glucose
  • b. Organic solvents (soap, detergents, etc)
  • c. Distilled water
  • d. Hypertonic solution of sodium chloride

Pregunta 111

Pregunta
Haemolytic Newborn disease can cause:
Respuesta
  • a. Anemia
  • b. Hypobilirubinemia
  • c. Decreased production of EPO
  • d. Death
  • e. Edema

Pregunta 112

Pregunta
Choose the correct statement concerning B-lymphocytes
Respuesta
  • a. They are mediators of humoral immunity
  • b. They are formed mainly in thymus
  • c. In effect of antigenic stimulation they form plasma cells which secrete immunoglobulins
  • d. They mediate cellular immunity

Pregunta 113

Pregunta
Functions of ionized calcium in organism are:
Respuesta
  • a) It maintains proper functioning of neurons and myocytes.
  • b) It maintains proper functioning of the cellular membranes (trans-membrane transport)
  • c) It is factor IV of coagulation supporting proper coagulation process.
  • d) It binds hemoglobin reducing hemoglobin affinity to oxygen.

Pregunta 114

Pregunta
Packed cell volume or hematocrit (PCV or Hct):
Respuesta
  • a) Is a part of blood volume that is occupied by erythrocytes
  • b) Is significantly lower in individuals treated with aspirin
  • c) Is inversely proportional to RBC (number of erythrocytes in blood).
  • d) Is proportionate to the volume of erythrocytes (MCV).

Pregunta 115

Pregunta
Biological effects of calcitonin are:
Respuesta
  • a) Low plasma calcium level
  • b) High plasma calcium level
  • c) Low plasma phosphate level
  • d) High plasma phosphate level
  • e) Increased excretion of calcium and phosphate through kidneys
  • f) Decreased excretion of calcium and phosphate through kidneys

Pregunta 116

Pregunta
Actions of vitamin D3 (cholecalciferol) are
Respuesta
  • a) It increases reabsorption of Ca 2, from intestines
  • b) It decreases reabsorption of Ca 2, from intestines
  • c) It increases reabsorption of Ca 2, from the nephron tubule
  • d) It decreases reabsorption of Ca 2, from the nephron tubule

Pregunta 117

Pregunta
Agglutinins
Respuesta
  • a) Against antigens of Rh system develop in childhood
  • b) In ABO system are mainly of IgM class.
  • c) In ABO system are inborn
  • d) In ABO system are synthesized after immunization with antigens A and B commonly present in environment.

Pregunta 118

Pregunta
Find agents able to produce hemolysis to normal erythrocytes
Respuesta
  • a. 0,5% NaCl
  • a. 0,9% NaCl
  • c. Hypertonic (hyperosmotic) solution
  • d. distilled water
  • e. soaps and detergents

Pregunta 119

Pregunta
Find the most specific features of the ECF:
Respuesta
  • a. Concentration of the Na = ion range 135-145 mEq/L
  • b. Concentration of the Cl- range 3,5-5 mEq/ L
  • c. Most of water of ECF is located in plasma of blood. Volume of ECF is approximately 5,0
  • d. Concentration of proteins in interstitial fluid is lower than plasma of blood

Pregunta 120

Pregunta
Identify correct statements concerning human blood types:
Respuesta
  • a. 35% of caucasians and most africans are Rh negative
  • b. The indirect antiglobulin test is used to detect immunoglobulins coating / binding erythrocytes
  • c. Blood type B has gene coding for the sequence of amino acid of the B- antigen of their erythrocytes
  • d. humans with type 0 in ABO system possess antigen H located in membranes of their erythrocytes
  • e. the maximum concentration of immunoglobulins in ABO system is observed at birth -

Pregunta 121

Pregunta
Identify right statements related to vitamin D3 :
Respuesta
  • a. it stimulates synthesis of calcium binding protein (CBP) in intestines
  • b. its final active form is produced by the enzymatic process of 25- hydroxylation in liver
  • c. its final active form is produced by the enzymatic process of 1 alpha- hydroxylation in kidneys
  • d. it originates from 7- dehydroaldosterone treated with ultraviolet rays in skin

Pregunta 122

Pregunta
. Which statements characterize IgM immunoglobulin?
Respuesta
  • a. it can easily produce aggregation of erythrocytes in environment of own plasma
  • b. it has two antigen- binding sites
  • c. it is a memory immunoglobulin
  • d. it is not able to cross blood - placenta barrier
  • e. it can bind complement
  • f. it is commonly found in fetal blood: it is called natural or inborn immunoglobulin

Pregunta 123

Pregunta
Factors that produce hemolysis
Respuesta
  • a. 0,6% saline
  • b. detergents
  • c. hypertonic glucose solution
  • d. hypertonic sodium solution

Pregunta 124

Pregunta
Intracellular receptors are
Respuesta
  • a. IP3
  • b. GABA
  • c. ryanodine
  • d. dhp
  • e. m3

Pregunta 125

Pregunta
. Complement system
Respuesta
  • a. Induces cell membrane Lysis via membrane Attack complex (MAC)
  • b. Induced by IgG
  • c. Leads to faster phagocytosis by macrophages
  • d. Increase vascular permeability
  • e. C5a leads to increased Chemotaxis

Pregunta 126

Pregunta
Hemolysis of normal erythrocytes occurs:
Respuesta
  • a. In high pH (alkalosis)
  • b. In temperature higher than 60°C.
  • c. In 5.0% solution of glucose
  • d. In distilled water.
  • e. In 0.2% saline

Pregunta 127

Pregunta
In B- typed individual, antigen B is generated from H antigen due to activity of
Respuesta
  • a. N-acetylogalatktoaminyl transferase catalyzing attachment of N-acetylogalactotiamine to H antigen
  • b. D-galactosyl transferase catalyzing attachment of isomaltose to H antigen
  • c. Fucose transferase catalyzing attachment of fucose to H antigen
  • d. D-galactose transferase catalyzes attachment of D galactose to D antigen
  • e. all ansers are incorrect
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