400577
Descripción
Test por thomasina413, actualizado hace más de 1 año
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Creado por thomasina413
hace más de 10 años
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Pregunta 1
Pregunta
A weak acid becomes more than 50% un-ionized following IV injection (blood pH = 7.4). The pKa of this weak acid could be...
Respuesta
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7.6
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7.4
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7.2
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1.5
Pregunta 2
Pregunta
When injected into the body, any of the local anesthetics used currently in clinical practice will be:
Respuesta
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less than 50% un-ionized
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more than 50% un-ionized
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50% un-ionized
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100% un-ionized
Pregunta 3
Pregunta
Sodium drug has pKa of 8.2. When injected into the blood, this drug will become:
Respuesta
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less than 50% un-ionized
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more than 50% un-ionized
-
50% un-ionized
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100% un-ionized
Pregunta 4
Pregunta
What situation most facilitates accumulation of local anesthetic by the fetus?
Respuesta
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maternal acidosis and fetal acidosis
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maternal acidosis and fetal alkalosis
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maternal alkalosis and fetal alkalosis
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maternal alkalosis and fetal acidosis
Pregunta 5
Pregunta
Potency is determined by what property(ies) of a local anesthetic?
Respuesta
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pKa
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lipid solubility
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protein binding
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both lipid solubility and protein binding
Pregunta 6
Pregunta
Speed of onset is determined by what property(ies) of a local anesthetic?
Respuesta
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pKa
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lipid solubility
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protein binding
-
both lipid solubility and protein binding
Pregunta 7
Pregunta
Duration of action is determined by what property(ies) of a local anesthetic?
Respuesta
-
pKa
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lipid solubility
-
protein binding
-
both lipid solubility and protein binding
Pregunta 8
Pregunta
Local anesthetics work on which segment(s) of the neuron?
Respuesta
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axon only
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cell body and axon
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axon and nerve terminal
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cell body, axon and nerve terminal
Pregunta 9
Pregunta
Conduction block occurs when the...
Respuesta
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ionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell
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ionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell
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un-ionized form of the local anesthetic binds to the voltage-gated sodium channel outside the cell
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un-ionized form of the local anesthetic binds to the voltage-gated sodium channel inside the cell
Pregunta 10
Pregunta
You can make your own local anesthetic. If you want the local anesthetic to have a fast onset, you will want to have the local anesthetic have what pKa?
Respuesta
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2.3
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7.0
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7.4
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11.5
Pregunta 11
Pregunta
Injection of local anesthetic at which of the following sites is most likely to result in systemic toxicity?
Respuesta
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epidural space
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paracervical tissue
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intercostal muscles
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brachial plexus
Pregunta 12
Pregunta
Methemoglobinemia can occur if what local anesthetic is used?
Respuesta
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Tetracaine
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Prilocaine
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Ropivacaine
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Mepivacaine
Pregunta 13
Pregunta
What condition most prevents passage of local anesthetic from fetus to mom?
Respuesta
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maternal alkalosis
-
maternal acidosis
-
fetal alkalosis
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fetal acidosis
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