Biochemistry Chapter 1

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USLME (Kaplan 2018 Chapter 1) Biochemistry Fichas sobre Biochemistry Chapter 1, creado por USMLE STEP1 el 25/07/2018.
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Pregunta Respuesta
Gene Expression occurs in the nucleus throughout... Interphase (There is no Gene Expression during the M Phase)
DNA Replication occurs during... S-phase
Nitrogen-containing bases with 2 rings in their structure. Purines
Nucleotides linked by 3′, 5′ phosphodiester bonds Nucleic Acids
A sample of DNA has 35% C; what is the % U? 15 %
Formed when 1 or more phosphate groups is attached to the 5′ carbon Nucleotide
Neurons; Skeletal muscle cells; Cardiac myocyte cells; Liver cells, are cells found in which phase of the Cell Cycle? G0 phase (Resting Cells)
Cells in G0 goes through transcription, translation and replication. T or F ? FALSE They don't do replication because they don't grow.
One nucleotide binds with another nucleotide by... A phosphodiester bond
Complementary bases binds with... Hydrogen bonds
What is the difference of a 30 nm chromatin to a 10 nm chromatin? The presence of H1 histone (condenses the nucleosomes)
Nucleosomes are formed by... An octomer formed by 2 copies of each histones: H2A, H2b, H3, H4.
Barr bodies (inactive X chromosomes) are found in the heterochromatin. T or F ? TRUE HeteroChromatin = Highly Condensed Inactive Genes
Insuline genes are found in the Heterochromatin of β-Pancreatic Cells. T or F ? FALSE Euchromatin is Expressed. Gene Expression because the DNA is exposed!!!
All genes are present in every cell in the body T or F TRUE
Methotrexate (MTX), trimethoprim (TMP), and pyrimethamine interferers with nucleotide synthesis by... (EXTRA) Disrupting pyrimidine synthesis (S phase)
Medicine that acts disrupting purine and pyrimidine synthesis (EXTRA) Hydroxyurea (S phase)
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