Hereditary WBC Disorders

Nota:

• Abnormal bleeding may be present in some individuals.

1. thrombocytopenia
2. giant platelets

1. neutrophils

1. Döhle-like bodies

   Nota:

   • Rod shaped inclusions at the edge of the cytoplasm. They are like Döhle bodies but larger.

1. unknown

1. dwarfism
2. gargoylism

1. All cell lines
   1. hallmark feature

1. coarse dark granulation

1. rare

1. common

1. leukemias
2. myleoproliferative disorders
3. severe infections

1. segmented neutrophils

1. hyposegmentation of nucleus
   1. heterozygotes
      1. peanut-shaped
      2. dumbbell-shaped
      3. pince-nez-shaped
   2. homozygotes
      1. spherical non-lobed

1. rare

1. neutropenia
2. albinism
3. photophobia
4. recurrent staphylococcus infections

1. neutrophils (mostly)
2. lymphocytes
3. monocytes

1. giant purple-gray granules