Therapeutic Drug Monitoring

Descripción

university Pharmacokinetics Mapa Mental sobre Therapeutic Drug Monitoring, creado por jenny schneider el 19/01/2014.
jenny schneider
Mapa Mental por jenny schneider, actualizado hace más de 1 año
jenny schneider
Creado por jenny schneider hace más de 10 años
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Resumen del Recurso

Therapeutic Drug Monitoring
  1. Assay techniques
    1. Assays using antibodies
      1. FPIA, RIA, EMIT
        1. Advantages: rapid, less training, small sample size
          1. Disadvantages: less specific (cross-react)
          2. chromatography techniques
            1. GC, HPLC
              1. Advantages: better specificity; good for research applications
                1. Disadvantages: equipment costly, needs bigger sample size, not as quick as antibody methods, need more training
              2. Blood Sampling
                1. correct time- usually trough level
                  1. correct type of tube
                    1. correct handling and storage
                    2. Assay requirements
                      1. Reproducible, accuracy and precision
                      2. Interpreting TDM result clinically
                        1. look at result AND patient response
                          1. Consider patient factors- e.g. disease, age
                            1. consider assay used and sample collection/handling
                              1. sample taken at correct time?
                                1. what is dosage regimen and when last dose was taken
                                2. good candidate for TDM
                                  1. good correlation between concentration and effect
                                    1. therapeutic range defined
                                      1. narrow therapeutic index
                                        1. large interindividual variability
                                          1. effect cannot be measured by simpler method
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