Transplantation

Descripción

Mapa Mental sobre Transplantation, creado por sam.hilton el 01/05/2013.
sam.hilton
Mapa Mental por sam.hilton, actualizado hace más de 1 año
sam.hilton
Creado por sam.hilton hace casi 13 años
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Resumen del Recurso

Transplantation
  1. Transplantable tissues
    1. Skin
      1. Kidnney
        1. Liver
          1. Heart
            1. Lung
              1. Pancreas
                1. Cornea
                  1. Bone Marrow
                    1. Face
                    2. Types
                      1. Autograft
                        1. Allograft
                          1. Isograft
                            1. Xenograft
                              1. Problems
                                1. Antibodies
                                  1. Hyperacute rejection
                                    1. Alpha1-3Gal
                                      1. transgenic pigs?
                                  2. Complement
                                    1. PERVS
                                2. Matching
                                  1. MHC
                                    1. MLR
                                      1. ABO
                                      2. Graft rejection
                                        1. Types
                                          1. Hyperacute
                                            1. ABO missmatch
                                              1. Pre existing antibodies
                                            2. Acute
                                              1. MHC missmatch
                                              2. Chronic
                                              3. T cell response
                                                1. Direct/indirect allorecognition
                                                2. Minor H antigens
                                                  1. MHC I
                                                    1. Polymorphic self proteins
                                                  2. GVHD
                                                    1. Immunosuppresive drugs
                                                      1. Cyclosporin A
                                                        1. Tacrolimus
                                                          1. Blocks calcineurin
                                                            1. dephosphorylation of NF-AT blocked
                                                              1. IL-2 blocked
                                                          2. Sirolimus
                                                            1. Binds mTOR
                                                              1. Prevents cell cycle in t cells
                                                            2. Side effects
                                                              1. Other drugs
                                                                1. Prednisone
                                                                  1. Azathioprine
                                                                    1. Anti-CD3 antibodies
                                                                      1. siRNA
                                                                        1. Tregs
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