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Muhammad's spleen is palpable

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Mapa Mental sobre Muhammad's spleen is palpable, creado por Salma Mk el 05/05/2017.
Salma Mk
Mapa Mental por Salma Mk, actualizado hace más de 1 año
Salma Mk
Creado por Salma Mk hace más de 9 años
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Resumen del Recurso

Muhammad's spleen is palpable
  1. causes of leukocytosis
    1. Neoplastic
      1. Histiocytic Neoplasms
        1. Lymphoid Neoplasms
          1. Hodgkin's lymphoma
            2. Non Hodgkin's lymphoma
              1. multiple myeloma
                1. WBC (lymphocyte) proliferations leading to discrete tissue masses in lymphoid organs -lymphoma
                  1. Acute Lymphoblastic Leukemia/ Lymphoma
                    1. 0-14 years
                      1. composed of pre-B or pre-T lymphoblasts
                        1. abrupt onset
                          1. blood film showing blasts
                            1. immunophenotyping= +Tdt and +Pas
                            2. Chronic Lymphocytic Leukemia
                              1. age=60+
                                1. proliferation of neoplastic lymphoid cells (B cells)
                                  1. C/P=hepatosplenomegaly and lymphadenopathy
                                    1. absolute lymphocytosis-hypogammaglobulinemia
                                      1. IHC=CD5+
                                  2. Myeloid Neoplasms
                                    1. Acute Myeloid Leukemia
                                      1. 15-60 years of age
                                        1. Abrupt Onset
                                          1. C/P=Pancytopenia
                                            1. Immunophenotype= CD13+ & MPO+
                                              1. >20% blast cells in BM and blood
                                              2. may present as discrete tissue masses-chloroma
                                                1. FAB classification
                                                  1. M3=RARA t(15:17)
                                                    1. treatment=ATRA
                                                      1. can present as DIC
                                                  2. Chronic Myeloproliferative Disorder
                                                    1. hyper proliferation of neoplastic myeloid progenitor cells while retaining capacity for terminal differentiation
                                                      1. JAK mutation
                                                        1. polycythemia vera
                                                          1. primary myelofibrosis
                                                            1. Essential thrombocythemia
                                                            2. Chronic Myeloid Leukemia
                                                              1. Etiology
                                                                1. more than 95% of patients with Philadelphia chromosome
                                                                  1. increase activity of tyrosine kinase due to formation of BCR-ABL complex
                                                                    1. escape from apoptosis
                                                                      1. less dependant on GF
                                                                        1. activation of RAS
                                                                      2. Treatment=tyrosine kinase inhibitor
                                                                        1. Imatinib
                                                                  2. Annual incidence= 1 to 2 cases per 100,00
                                                                    1. abrupt onset of pancytopenia
                                                                      1. 40-60 years
                                                                        1. stages
                                                                          2. Investigations
                                                                            1. CBC
                                                                              2. Blood film
                                                                                2. Genetic tests
                                                                                  1. FISH
                                                                                    2. PCR
                                                                        2. Reactive
                                                                          1. Neutrophilia
                                                                            1. bacterial infections
                                                                              1. corticosteroids
                                                                                1. MI
                                                                                2. Lymphocytosis
                                                                                  1. viral infections
                                                                                    1. phenytoin
                                                                                    2. Eosinophilia
                                                                                      1. Type 1 hypersensitivity
                                                                                        1. helminthic infection
                                                                                        2. Monocytosis
                                                                                          1. Chronic infection
                                                                                            1. Autoimmune disease
                                                                                              1. Malignancy
                                                                                              2. Leukemoid Reaction
                                                                                                1. excessive leukocytosis
                                                                                                  1. 15-100,00/mm3
                                                                                                  2. elevated NAP
                                                                                                    1. toxic granulations & doehle bodies
                                                                                                2. Hematological History Taking
                                                                                                  1. Anemia symptoms
                                                                                                    1. Fatigue, weakness
                                                                                                      1. dyspnea
                                                                                                        1. palpatations
                                                                                                          1. dizziness
                                                                                                            1. splenomegaly
                                                                                                              1. feeling of fullness
                                                                                                            2. WBC symptoms
                                                                                                              1. infections
                                                                                                                1. LN swelling
                                                                                                                  1. B symptoms
                                                                                                                    1. weight loss
                                                                                                                      1. fever
                                                                                                                        1. night sweats
                                                                                                                      2. platelet symptoms
                                                                                                                        1. rashes
                                                                                                                          1. ecchymosis
                                                                                                                            1. easy bruising
                                                                                                                              1. gum/nose bleeding
                                                                                                                              2. Past medical/surgical history
                                                                                                                                1. transfusions
                                                                                                                                  1. GI surgery
                                                                                                                                    1. Drugs
                                                                                                                                      1. NSAID
                                                                                                                                        1. corticosteroids
                                                                                                                                          1. warfarin
                                                                                                                                        2. Haematological Physical RExamination
                                                                                                                                          1. Inspection
                                                                                                                                            1. hand
                                                                                                                                              1. nail changes
                                                                                                                                                1. pale palmar creases
                                                                                                                                                2. forearm
                                                                                                                                                  1. scratch marks
                                                                                                                                                    1. joint swelling
                                                                                                                                                    2. eyes
                                                                                                                                                      1. pallor
                                                                                                                                                        1. jaundice
                                                                                                                                                        2. mouth
                                                                                                                                                          1. angular stomatitis
                                                                                                                                                            1. gum hypertrophy
                                                                                                                                                          2. Palpation
                                                                                                                                                            1. of Lymph nodes
                                                                                                                                                              1. Cervical
                                                                                                                                                                1. Axillary
                                                                                                                                                                  1. Inguinal
                                                                                                                                                                    1. epitrochlear

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