Main clinical cognitive features of Huntington’s disease include the following except:
B. Memory difficulties
A. Mental slowing
C. Language severe problems
D. Language well preserved
Question 2 Characteristics in Early stages of Huntington’s disease: (multiple answers possible)
A. Chorea
B. Agitated /mood swings
C. Distractable
D. Demented
Characteristics in Late stages of Huntington’s disease except: (multiple answers possible)
B. Dystonia/bradykinetic
C. Mood swings
A. Abulic
Question 7 The gene related to Huntington’s disease is Huntingtin (htt) and in order to become pathogenic it should have:
B. >36 insertions
C. >36 deletions
D. >36 GAC repeats
A. >36 CAG repeats
Main clinical psychiatric features of Huntington’s disease include: (multiple answers possible)
A. Irritability
B. Stable mood
D. Compulsive behaviour
C. Social withdrawal
The brain structures which are mainly affected by Huntington’s disease are: (multiple answers possible)
A. Sustantia Nigra
B. Cerebral cortex
C. Hippocampus
D. Striatum
Main clinical motor features of Huntington’s disease include: (multiple answers possible)
B. Evolution from hyperkinetic to hypokinetic
C. Evolution from hypokinetic to hyperkinetic
D. Gait abnormalities
Question 8 Other features frequently found in patients with Huntington’s disease are the following except:
A. Metabolic abnormalities
B. Weight gain
C. Circadian rhythm disturbances
D. Autonomic abnormalities
Question 9 Huntington’s disease is an inherited disorder, it is a _____ condition.
Aut Dom
Aut Rec
X Dom
X Rec
Question 10 Mutated Huntingtin lead to: (multiple answers possible)
A. Transcription interference
B. Formation of inclusions
C. Cellular dysfunction
D. Cell death
The gene defect Huntington’s disease is known to be on Chromosome
2
4
9
11
