Function of CC multiplier

Initial concentration of CCM

Single effect generation

The single effect

How does OSP' change in nephron

What does length of LOH determine?

What is the vasa recta?

What is the function?

Salt diffusion from VR

Summary

Water reabsorption in VR

Summary

Diagram of urea movement

Where is [urea] high

Why does inner medulla have a steep osmotic '?

Urea Uniporters

Hormonal control Vasopressin (ADH)

UT-A2

Vasopressin

How does ADH do this?

What happens when dehydrated

Renin

Stimulators of renin secretion