Hormonal Therapy
(Antiandrogens)
"tamides"

Hormonal Therapy
Androgen Biosynthesis Inhibitors

Hormonal Therapy
GNRH/LHRH Agonists
[Pulsatile and non-pulsatile admin]

Hormonal Therapy
GNRH/LHRH Antagonists

How does LHRH works

What is the effect of administering LHRH agonist in a pulsatile manner (i.e., similar to intermittent dosing)?

What is the effect of administering LHRH agonist in a non-pulsatile manner?

For ADT (androgen deprivation therapy), what is the appropriate medication

Among the LHRH agonist therapy, wh/ one is considered medical castration?
a. Pulsatile
b. Non-pulsatile

There 2 methods for ADT wh/ are

What is the best indication of GNRH/LHRH antagonist - Degarelix acetate (Firmagon®)?

What are the differences btw Eligard and Lupron formulation?

LHRH agonists AEs include

Which of the ff is a steroidal antiandrogen and does not bind to AR?
a. Flutamide
b. nilutamide
c. bicalutamide
d. enzalutamide
e. Abiraterone acetate

Which of the ff is a nonsteroidal antiandrogen?
a. Flutamide
b. nilutamide
c. bicalutamide
d. enzalutamide
e. Abiraterone acetate

The androgen receptor (AR) is located in ------ and upon binding, it translocate into ------ and affects ---------

------ and ------ binds to AR in the cytoplasm and affects ---------- in the nucleus.

What is/are indications for antiandrogen drugs?

Which of the ff is a pure antiandrogen and has been linked to seizure activity in clinical trial?
a. Flutamide
b. nilutamide
c. bicalutamide
d. Enzalutamide
e. Abiraterone acetate

-------------- does not act as an androgen receptor antagonist, but as a selective and irreversible inhibitor of CYP17 (17 alpha-hydroxylase/ C17,20-lyase), an enzyme required for androgen biosynthesis which is expressed in testicular, adrenal, and prostatic tumor tissues.

------------- inhibits
the formation of the testosterone precursors dehydroepiandrosterone (DHEA) and androstenedione

How is Abiraterone acetate administered?

Antiandrogen therapy AEs

Flutamide carries a black-box warning for ------------

Nilutamide has a black-box warning for ------------

Abiraterone acetate specific SEs include---------?

Which of the ff has has the lowest rates
of diarrhea and hematuria often preferred by patients
a. Flutamide
b. nilutamide
c. bicalutamide
d. Enzalutamide
e. Abiraterone acetate

Which of the ff can cause a decrease in cortisol synthesis which results in adrenal insufficiency and you must add prednisone.
a. Flutamide
b. nilutamide
c. bicalutamide
d. Enzalutamide
e. Abiraterone acetate