DM1

Four types: adult-onset, congenital, childhood-onset and late-onset oligosymptomatic
The younger the onset, the more severe the symptoms

Core symptoms:

myotonia
progressive muscle weakness
cataracts

Other symptoms:

muscle atrophy
cardiac conduction defects and/or tachyarrhythmia
neurological symptoms: behavioural changes, cognitive impairment and hypersomnia
gastrointestinal problems: constipation, diarrhoea and incontinence
balding (typically in men)
fertility problems
ptosis
type II diabetes
Sudden cardiac death as a result of heart problems can occur in approximately one third of patients
Women also have a greater risk of complications during pregnancy: miscarriage, premature labour, prolonged labour, placenta previa and post-partum haemorrhage

DM2

generally milder form of the disorder with a more variable clinical phenotype
Myotonia can be absent in DM2 patients
first symptom typically muscle weakness of the proximal limbs
Unlike DM1, DM2 does not have severe childhood forms, and prognosis is generally good with typically no reduction in life expectancy seen
greater prominence of severe myalgic pain

	Creado por Ellie Quinn hace alrededor de 10 años

Apunte sobre Myotonic Dystrophy, creado por Ellie Quinn el 29/05/2014.