Winter:

The cold weather led to a slow down in the spread of the disease
With a decline in the rat population there was less contact with humans
Once the warmer weather settled in during spring the rat population increased and so did the spread of the disease
April 1666 - the total death number was 73

Spring:

June - the number of deaths rose above 20, this was the first time since the previous October
July - 56 people died
August - another 78 died
Plague deaths began to decrease from September into November