16338028
Description
Flashcards by Simeon Crane, updated more than 1 year ago
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Created by Simeon Crane
over 5 years ago
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| Question | Answer |
| Combinations of calcium channel blockers and beta blockers can predispose patients to what kind of dysrhythmia? | Heart Block |
| What type of dysrhthmia is Atrial Fibrillation? | Re-entrant Rhythm |
| Name a therapeutic agent that is known to interfere with a digoxin assay? | Aldosterone Antagonists |
| Name a Beta-blocker that exhibits class 3 pharmacological action? | Sotalol |
| Which class of drugs are most likely to cause early after- depolarizations in ventricular myocytes? | Potassium channel blockers |
| Name an antiarrhythmic that requires thyroid function testing before starting? | Amiodarone |
| What is the name of the enzyme that converts T4 into T3 inside the target tissues? | Iodothyronine deiodinase |
| What is a goitre? | Large thyroid gland that is not producing thyroid hormones |
| What is Exophthalmos? | Widening of the eyes |
| What is Exophthalmos caused by? | Thyroid- stimulating immunoglobulin |
| Name a beta blocker that has class 3 antiarrhythmic properties. | Sotalol |
| When can Bisoprolol be used for rhythm control? | In a re-entrant rhythm that involves the AV node. (such as Wolff-Parkinson-White syndrome) |
| What are the 4 classes of drugs found in the Vaughan-Williams classification of Anti-arrhythmic drugs? | 1- Sodium channel blockers 2- Beta blockers 3- Potassium channel blockers 4- Calcium channel blockers |
| What is the mechanism of action of Digoxin? | Digoxin is a cardiac glycoside that increases the force of myocardial contraction and reduces conductivity within the atrioventricular (AV) node |
| What are the 7 components of the CHA(2)DS(2)-VASc score? | C- Congestive HF H- Hypertension A- Age>75 D- Diabetes Mellitus S- Stroke V- Vascular disease A- Age 65-74 S- Sex(female) |
| What are the 7 components of the HAS-BLED score? | H- Hypertension A- Abnormal renal and liver function S- Stroke B- Bleeding L- Labile INR E- Elderly D- Drugs or alcohol |
| What is the mechanism of action of Rivaroxaban? | Rivaroxaban is a direct inhibitor of activated factor X (factor Xa) |
| What is the name of the study that showed apixaban was superior to warfarin in preventing stroke? | ARISTOTLE |
| What is the best reason for why we conduct drug therapeutic monitoring? | To monitor a drug with a narrow therapeutic range |
| What are the 4 most common biological sample processing strategies? | - PPT (protein precipitation) - LLE (liquid liquid extraction) - SPE (solid phase extraction) - DAS (dilute and shoot) |
| What is the most commonly used immunoassay in DTM (drug therapeutic monitoring)? | Enzyme-linked immunosorbant assay (ELISA) |
| What is the most common ECG characteristic of atrial fibrillation? | Absent P waves |
| What is the normal resting heart rate for adults? | 60 to 100 beats per minute |
| What is the mechanism of action of Beta Blockers in treating atrial fibrillation? | They reduce automaticity and conduction through the AV node |
| What class of drug is Warfarin? | Vitamin K antagonist |
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