16377872
Description
Flashcards by Simeon Crane, updated more than 1 year ago
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Created by Simeon Crane
over 5 years ago
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| Question | Answer |
| What is Rheumatoid Arthritis? | A long-term autoimmune condition that causes pain, swelling and stiffness in the joints |
| What is the main adverse drug reaction that can occur with hydroxy- chloroquine therapy? | Ocular toxicity resulting from corneal deposits and macular lesions |
| What is the isoelectric point? | The PH at which a protein has no net charge |
| What are the 3 ways peripheral tolerance occurs? | 1. Deletion 2. Anergy (inability to respond) 3. Supression |
| What is the mode of action of Etanercept? | Binds to and inactivates soluble TNFα (alpha) |
| What target is inhibited by allopurinol? | Xanthine Oxidase |
| What are Biosimilar medicines? | Biological structures which produce a similar clinical effect to their originator molecules with little or no meaningful post- translational changes |
| How does the removal of T-cell effector epitopes reduce the immunogenicity of a biologic? | By disrupting HLA binding. Naive T- cell stimulation is thus reduced |
| What are the NICE criteria for access to a first line biologic DMARD for rheumatoid arthritis? | Has already tried methotrexate and another DMARD and has active rheumatoid arthritis, as assessed by a rheumatologist on two separate occasions |
| What score on the ACR classification criteria confirms RA? | 6 or above |
| What are the two types of Inflammatory Bowel Disease? | Crohn's Disease Ulcerative Colitis |
| What is Fibromyalgia syndrome? | A chronic musculoskeletal syndrome characterized by diffuse pain in the absence of synovitis or myositis |
| What two autoantibodies are present in RA? | Rheumatoid factor (RF) Anti-cyclic citrullinated peptide antibodies (Anti-CCP) |
| What does a DAS 28 score of 7 indicate? | That the patients RA is 'very active' |
| What is the mechanism of action of methotrexate in RA? | Inhibition of purine biosynthesis and cytokine expression; induction of monocyte apoptosis |
| Name three non immunosuppressive DMARDs? | Gold Sulfasalazine Hydroxychloroquine |
| What is the mechanism of action of abatacept? | It blocks costimulation between an APC and a T cell and therefore prevents T cell activation |
| What drug is given alongside methotrexate to decrease adverse drug reactions? | Folic acid |
| What is Etanercept made of? | Two copies of human soluble TNF receptor fused to the Fc portion of the human IgG antibody |
| Name the 4 types of antinuclear antibodies that can often be detected in a patient with SLE. | Anti-smith Anti-Ro Anti-La Anti-double-stranded DNA |
| What are the two phases of treatment of lupus nephritis? | Induction and maintenance |
| What starting dose of methotrexate is given to patients for rheumatoid arthritis? | 7.5mg once weekly |
| What is the maximum dose of methotrexate given for RA? | 20mg once weekly |
| What joint does the majority of initial gout attacks affect? | The 1st MTP joint |
| In patients with renal impairment, what would be an appropriate ULD? | Febuxostat |
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