Thiazolidinediones

Question	Answer
Thiazolidinediones Image: b892411c-6a35-4f37-993c-f15ade82ced0 (image/png)	Rosiglitazone - Pioglitazone Starting dose: 2-4 mg QD or BID \| 15 mg QD Half life: 3-4 hrs \| 3-7 hrs Image: 57a72001-991d-4965-a271-d3301950ccc6 (image/png)
Image: 1c9a63d5-1bbb-49a7-9571-629d3059daa6 (image/jpg)	1. Enhance insulin sensitivity in muscle &fat by increasing glucose transporter expression. 2. Increase glucose uptake in peripheral tissue. 3. Decreases hepatic gluconeogenesis.
Weight gain : All of the thiazolidinediones cause weight gain. It is both dose-dependent and time-dependent Image: a2a9b0a5-d696-4e72-a7c3-716ceb9cd204 (image/png)	There is an increasing body of evidence suggesting that thiazolidinediones decrease bone density and increase fracture risk, particularly in women. Image: c6260e04-6275-4757-b58b-32bff0f0ca49 (image/png)

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	Created by nofanko almost 9 years ago