3747354
Description
Flashcards by Pip Fraggle, updated more than 1 year ago
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Created by Pip Fraggle
over 8 years ago
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| Question | Answer |
| List the three granulocytes | neutrophils, basophils, eosinophills, |
| List all the cells that rise from a myeloid stem cell | -neutrophil -basophil -eosinophill -platelets -erythrocytes -monocytes (from monoblasts) |
| List all the cells that rise from a Lymphoid stem cell | -Natural killer cell -t-cell -b-cell (plasma cell) |
| what is the path of development of a neutrophil? | 1) Pluripotent stem cell in the bone marrow>Myeloid stem cell-->Myeloid blast --> Promyelocyte-->neutrophilic myelocyte-->neutrophilic metamyelocyte-->neutrophilic band cell-->Granulocyte --> neutrophil (released into circulation when needed) |
| what is the path of development of a basophil | 1) Pluripotent stem cell in the bone marrow>Myeloid stem cell-->Myeloid blast --> Promyelocyte-->neutrophilic myelocyte-->neutrophilic metamyelocyte-->neutrophilic band cell-->Granulocyte --> basophil (released into circulation during allergic and hypersensitive reactions) |
| what is the path of development of an eosinophil | 1) Pluripotent stem cell in the bone marrow>Myeloid stem cell-->Myeloid blast --> Promyelocyte-->neutrophilic myelocyte-->neutrophilic metamyelocyte-->neutrophilic band cell-->Granulocyte --> eosinophil (released into circulation during allergic reactions and parasitic infection) |
| what is the development path of a B lymphocyte/plasma cell | 1) Pluripotent stem cell in the bone marrow 2) Lymphoid stem cell 3) lymphoblast 4)prolymphocyte 5)B-lymphocyte (in bone marrow) 6) plasma cell (then moves to lymphoid tissue to proliferate) |
| what is the development path of a T lymphocyte? | 1) Pluripotent stem cell in the bone marrow 2) Lymphoid stem cell 3) lymphoblast 4)prolymphocyte 5)T- lymphocyte (in lymphoid tissue) |
| what is the development path of a monocyte/macrophage | 1) Pluriponent stem cell in the bone marrow 2) Myeloid stem cell 3)Promonocyte 4) monocyte (released into blood stream) 5) macrophage |
| what is the function of a neutrophil | damage control (initial leukocyte releases at injury. Works at clearing cell debris and invading microbes) |
| what is the function of a basophil? | response in allergic and hypersensitive reactions |
| what is the function of an eosinophill? | response to allergic reactions and parasitic invasion |
| what is the function of a B-lymphocyte? | to form plasma cell (which produce antibodies) and take place in humoral-mediated immunity |
| what is the function of a T-lymphocyte? | activate other immune cells and help with cell-mediated immunity |
| what is the role of the lymphoid tissues? | -mature lymphocytes |
| Define "leukopenia" | decrease in the absolute number of leukocytes in the blood |
| Define "neutropenia | low number of neutrophils in the blood (mild:1000-1500/microliter) (moderate: 500-1000/microliter) (severe: less than 500/microliter) |
| define "granulocytopenia" | decrease in granulocytes |
| define "aplastic anemia" | anemia, throbocytopenia and/or agranulocytosis induced by affected myeloid cells |
| what are congenital causes of neutropenia? | -Kostmann syndrome (inherited autosomal recessive) -Periodic/cyclic neutropenia (autosomal inherited, possible impaired feedback regulation) |
| what are causes of aquired neutropenia | -aplastic anemia -cancer treatment (radiation/chemotherapy) -nonmyelogenous leukemia -lymphoma -autoimmune issues |
| Define "mononucleosis" | lymphoproliferative disorder, characterized by Epstein -Barr virus |
| describe the pathogenesis of mononucleosis | -transmitted through bodily fluid infected by Epstein-Barr virus - |
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