3804413
Description
Flashcards by Melissa Denker, updated more than 1 year ago
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Created by Melissa Denker
over 8 years ago
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| Question | Answer |
| Hepatitis A Virus Structure? (2) Transmission? (3) Immunity? (3) | STRUCTURE: Picornavirus; ssRNA TRANSMISSION: Faeco-oral; contaminated food/water; person-person IMMUNITY: After previous infection; after vaccine; after hep A immunoglobulin |
| Hepatitis A Incubation period? (1) Symptoms? (6) Prognosis? (3) Treatment? (2) | INCUBATION PERIOD: 30 days SYMPTOMS: Fever; abdominal pain; diarrhoea; jaundice; itch; muscle pains PROGNOSIS: Rarely fatal; self-limiting; more severe with increasing age TREATMENT: Maintain hydration; avoid alcohol |
| Diagnosis of Hepatitis A Serology? (2) Other tests? (2) | SEROLOGY: Hepatitis A IgM Positive - indicates new infection IgG Positive - indicates previous infection/vaccination OTHER TESTS: LFTs - abnormal, e.g. elevated AST/ALT RNA in stool - indicates new infection |
| Hepatitis A Vaccine Efficacy? (1) Duration of protection? (1) Pre-exposure use? (4) Post-exposure use? (2) | EFFICACY: 95% PROTECTION: life PRE-EXPOSURE USE: Travellers; homosexual men; IVDUs; chronic liver disease patients POST-EXPOSURE USE: Outbreak control (effective up to 7 days after) |
| Hepatitis A Immunoglobin Duration of protection? (1) Pre-exposure use? (2) Post-exposure use? (2) | PROTECTION: 3-6 months PRE-EXPOSURE USE: Patients allergic to vaccine; travellers with less than 4 weeks before travel POST-EXPOSURE USE: Outbreak control (effective up to 14 days after) |
| Chronic carriage of Hepatitis A (1) | Not possible |
| Hepatitis E Virus Structure? (2) Transmission? (2) Immunity? (1) | STRUCTURE: ssRNA; calicivirus TRANSMISSION: Faeco-oral; infected meat IMMUNITY: None |
| Hepatitis E Incubation period? (1) Symptoms? (7) Prognosis? (2) Treatment? (3) | INCUBATION PERIOD: 40 days SYMPTOMS: Fever; abdominal pain; diarrhoea; jaundice; itch; muscle pain; neurological effects PROGNOSIS: More fatal than hep A; fatality rate: 1-3% TREATMENT: Supportive, e.g. maintain hydration, avoid alcohol |
| Diagnosis of Hepatitis E Serology? (1) Other tests? (1) | SEROLOGY: Hep E IgM Positive - indicates new infection OTHER TESTS: Hep E Virus in stool - indicates new infection |
| Hepatitis E Vaccine (1) | None |
| Chronic carriage of hepatitis E (2) | Yes WHO? Highly immunosuppressed patients |
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