40099876
Description
Mind Map by Javier Viñas, updated more than 1 year ago
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Created by Javier Viñas
over 1 year ago
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Nucleoside/Nucleotide Reverse
TranscriptaseInhibitors (NRTIs)
- Mechanism
- Competitive inhibition of HIV-Reverse transcriptase
- Need phosphorylation to be activated
- Produce viral protein but premature chain
termination (absent 3' oh) → Inhibition of 3'
to 5' phosphodiester bond formation.
- Competitive inhibition of HIV-Reverse transcriptase
- Suffix (-Dine)
- Lamivudine
- Can cause Peripheral neuropathy
- Can also treat Hepatitis B
- Discontinuations can cause a
flare up of hepatitis B
- Discontinuations can cause a
flare up of hepatitis B
- Can cause Peripheral neuropathy
- General Adverse Effects
- Mitochondrial Toxicity
- Lactic Acidosis
- Mitochondrial Toxicity
- Zidovudine
- Used in pregnancy and breastfeeding
- Multiple Adverse Effects
- Myelosuppression
- Anemia
- Granulocytopenia
- lipodystrophy (central
obese but thin legs)
- Myelosuppression
- Used in pregnancy and breastfeeding
- Stavudine
- Peripheral neuropathy
- Lipodystrophy (central obese but thin legs)
- Peripheral neuropathy
- Tenofovir
- Nucleotide not phosphorylate to be activate
- Treats Hep B
- Nucleotide not phosphorylate to be activate
- Didanosine
- Can dose dependent pancreatitis
- Peripheral neuropathy
- Can dose dependent pancreatitis
- Abacavir
- Hypersensitivity associated with HLA-B 57:01 Allele
- Type 4 hypersensitivity
- Delay rash
- Delay rash
- Type 4 hypersensitivity
- Hypersensitivity associated with HLA-B 57:01 Allele
- Emtricitabine
- Hyperpigmentation
in palms and soles
- Hyperpigmentation
in palms and soles
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