15821295
Alzheimer's Disease
- Limbic
system
anatomy
- Hippocampal
Formation
- Fornix
- Physiology of
Memory &
Learning
- Information Processing Model
- Sensory Memory
- Working Memory
- Long-Term Memory
- Explicit
- Implicit
- Explicit
- Long-Term Memory
- Working Memory
- Sensory Memory
- Information Processing Model
- Delirium
- causes
- causes
- Differential Diagnosis of dementia
- Types of Dementia
- Alzheimer’s Disease
- Vascular Dementia
- Lewy Body Dementia
- Fronto-Temporal Dementia
- Alcohol-related Dementia
- Mixed Dementia
- Alzheimer’s Disease
- Causes of dementia
- Degenerative neurological diseases
- These include Alzheimer's
disease, Parkinson's disease,
Huntington's disease, and
some types of multiple
sclerosis. These diseases get
worse over time.
- These include Alzheimer's
disease, Parkinson's disease,
Huntington's disease, and
some types of multiple
sclerosis. These diseases get
worse over time.
- Vascular disorders
- Traumatic brain injuries
- Infections of the
central nervous
system
- Certain types of
hydrocephalus
- Degenerative neurological diseases
- Risk factors
of dementia
- Dementia
investigation
- Risk factors of
alzheimer's
disease
- Age\Family history\Down’s
syndrome\Head
injuries\Cardiovascular
disease\Smoking\Obesity\Diabetes\HBP\High
LDL
- Age\Family history\Down’s
syndrome\Head
injuries\Cardiovascular
disease\Smoking\Obesity\Diabetes\HBP\High
LDL
- Causes of
alzheimer's disease
- Genetics
- Lifestyle
- Environment
- Genetics
- Signs and
Symptoms of
Alzheimer's
- Pathophysiology of Alzheimer's
- Investigations and Clinical Diagnosis
- There's no specific test
today that confirms
Alzheimer's disease.
- 1st investigations to order
- bedside cognitive testing\
complete blood count\ metabolic
panel\ serum thyroid-stimulating
hormone (TSH)
- bedside cognitive testing\
complete blood count\ metabolic
panel\ serum thyroid-stimulating
hormone (TSH)
- Investigations to consider
- Cerebrospinal fluid (CSF) analysis\
serum RPR/VDRL\ serum HIV\ formal
neuropsychological testing
- Cerebrospinal fluid (CSF) analysis\
serum RPR/VDRL\ serum HIV\ formal
neuropsychological testing
- Emerging tests
- amyloid-positron emission tomography (PET)
- amyloid-positron emission tomography (PET)
- There's no specific test
today that confirms
Alzheimer's disease.
- Epidemiology
- More than 25 million people in the world today are affected by dementia, most suffering from
Alzheimer's disease.
- Drugs used in
Alzheimer’s
disease
- Reversible Acetylcholinesterase inhibitors
- Selective
- Rivastigmine
- Galantamine
- Donepezil
- Rivastigmine
- Non selective
- Tacrine
- Tacrine
- Side effects
- Diarrhea\ Urination\ Miosis\
Bronchospasm\ Excessive salivation\
Lacrimation\ Sweating\ Nausea
(excessive GI movements)\
Hypotension\Bradycardia
- Diarrhea\ Urination\ Miosis\
Bronchospasm\ Excessive salivation\
Lacrimation\ Sweating\ Nausea
(excessive GI movements)\
Hypotension\Bradycardia
- MOA
- Selective
- NMDA antagonist
- Memantine
- Side effects
- Confusion
Agitation
Restlessness
- Confusion
Agitation
Restlessness
- MOA
- Memantine
- Reversible Acetylcholinesterase inhibitors
- Principles of drug
use for elderly
- Neuropsychological Tests
- Uses
- Mini Mental
State
Examination
- The mini mental state
test includes only 11
questions that
examines five areas of
the cognitive function
- Orientation
Registration
Attention and
calculation
Recall
Language
- Orientation
Registration
Attention and
calculation
Recall
Language
- A score of 28 – 30 (Normal cognitive
state)\ A score of 25 – 27 (Mild
cognitive impairment)\ A score of 21 –
24 (Mild dementia)\ A score of 11 – 20
(Moderate dementia)\ A score of less
than 10 (Severe dementia)
- The mini mental state
test includes only 11
questions that
examines five areas of
the cognitive function
- Uses
- Complication
- Restlessness and
agitation\ Bladder and
bowel problems\
Depression\ Falls\
Infections\ Wandering\
Malnutrition and
dehydration
- Restlessness and
agitation\ Bladder and
bowel problems\
Depression\ Falls\
Infections\ Wandering\
Malnutrition and
dehydration
- Prognosis
- Life expectancy of
people with AD is
reduced Following
diagnosis it typically
ranges from three to
ten years
- Survival is shorten
by: severe
cognitive
impairment &
coincident
diseases
- Life expectancy of
people with AD is
reduced Following
diagnosis it typically
ranges from three to
ten years
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