Amyloidosis

Lamees  Sheikh
Mind Map by Lamees Sheikh , updated more than 1 year ago
Lamees  Sheikh
Created by Lamees Sheikh about 1 year ago
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Description

Immunity

Resource summary

Amyloidosis
  1. definition
    1. deposition of amyloid in the Interstitial tissues +wall of BVs
      1. Structure
        1. Chemical
          1. AA
            1. AL
              1. Transthyretin
                1. B2 microglubulin
                  1. b amyloid protein
                  2. physical
                    1. structure
                      1. 95%=non branching fibrills 5%=p components +glycoprotein
                        1. non branching fibrills in the shape of crossed B pleated sheets
                          1. plasma protein primary amyloidosis light chain Igs
                            1. no Igs liver 2ry amyloidosis
                              1. normal serum protein transports thyroxin and retinol senile systemic amyloidosis +familial amyloid polyneropathy
                                1. long term dialysis synovium+joints+tendon sheath.
                                  1. alzheimer
                                    1. Classification
                                      1. primary
                                        1. secondary
                                          1. Myeloma pts serum has Bence Jones prts(kappa ,lambda)
                                            1. all the other diseases
                                              1. pathogenesis: defective degradation in bence jones prts
                                                1. pathogenesis: liver produces SAA under the effect of IL1 which leads to insoluble SAA
                                                  1. site
                                                    1. localized in a single organ
                                                      1. systematic in multiple organs
                                                        1. clinical feature in different organs :
                                                          1. generally : weakness ,weight loss, fatigue
                                                            1. heart: cardiomyopathy+arrhythmia
                                                              1. in kidney: renal failure
                                                                1. in liver:hepatosplenomegaly
                                                                  1. diagnosis: must be done by biopsy stained by Congo red/in generalizes most cases have rectal and gingival amyloid.
                                                                    1. sites: heart,skin,peripheral nerves,tongue,respiratory
                                                                      1. sites:kidney,liver,spleen, LNs,adrenal,thyroid.
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