Oncolytic Virotherapy

Cancer
1. Divides without control
2. Resist of receiving and sending signal
3. Exhibit immortality
4. Form tumours
  1. Metastasis
5. Compete nutrients from surrounding cells and eventually cell deaths
Virology
1. virus
  1. Smallest living thing
  2. Host
    1. replication and metabolisation
    2. Integrating viral genes into host genes
      1. Viral vector of gene
      2. cell lysis
    3. Provide protection to virus from immune system
  3. Outside of host
    1. Unable to metabolite and replication
    2. Expose to enviroment and immune system
Treatment of cancer
1. More effective than classic gene therapy
2. Use of oncolytic viruses
  1. Wild or modified virus target on cancer cells
  2. Ideal oncolytic viruses
    1. Highly selective
    2. Replication competent
    3. Well tolerated
    4. Less genomic integration
    5. Systemic administration
    6. Able to carry therapeutic or diagnostic payloads directly to the tumor
Oncolytic viruses
1. Adenovirus
2. Herpes Simplex Virus
  1. Breast cancer
3. Stomatic Virus
4. Reovirus
  1. Steam cells
5. Coxsakie Virus
  1. CVB
  2. CVA21
    1. ICAM-1 & DAF
    2. MiRNA suppress gene expression to reduce side effects
    3. Upper tract infection & Myotitis
    4. Systemic delivery
    5. Multiple myeloma
      1. Highly selective
  3. CVA13, CVA15 CVA18
    1. Melanoma
6. Vaccinia Virus
Combination with other therapy
1. Photodynamic therapy
  1. Increase the efficiency of oncolytic vaccinia virus against metastatic tumours in mic
2. Antiangiogenic Therapy
  1. Regression of tumors
3. Chemical Therapy
  1. Increase in purging effect by using prodrug

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Oncolytic Virotherapy

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	Created by Agito Sears over 11 years ago