Lipid-mediated insulin resistance

Description

Mind Map on Lipid-mediated insulin resistance, created by Santiago Felipe Cepeda Silva on 10/15/2021.
Santiago Felipe Cepeda Silva
Mind Map by Santiago Felipe Cepeda Silva, updated more than 1 year ago
Santiago Felipe Cepeda Silva
Created by Santiago Felipe Cepeda Silva over 1 year ago
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Resource summary

Lipid-mediated insulin resistance
  1. THE RI
    1. ASSOCIATED WITH
      1. METABOLIC DISORDER
        1. ectopic tissue accumulation of lipids
          1. AMONG THEM, THE SKELETAL MUSCLE
            1. EVIDENCED IN PEOPLE AND ANIMALS
              1. the influence of lipids on the induction of DI
                1. IN DIET
                  1. HYPERCALORIC
                    1. HYPERGRASE
                    2. HOURS LATER, THE PATIENT IS INDUCED RI
            2. DISCUSSION
              1. HOW DO LIPIDS ACCUMULATE IN EPTOPIC TISSUES?
                1. imbalance between fatty acid uptake and oxidation of fatty acids
                  1. ALLOWING
                    1. accumulation in cells of specific tissues..
                      1. HOWEVER
                        1. individuals with IR tend to be characterized by lower mitochondrial density and ATP synthesis in skeletal muscle. synthesis in skeletal muscle
                          1. IT IS PROPOSED THAT
                            1. existence of mitochondrial dysfunction in skeletal muscle of individuals with skeletal muscle of individuals with IR
                              1. AGREEING THAT
                                1. the determinants of ectopic lipid ectopic lipid accumulation, particularly at the level of skeletal muscle, is an area of intense study. skeletal muscle correspond to an area of intense study.
                2. to how lipids interfere with insulin signaling. insulin signaling?
                  1. KNOWN
                    1. diglycerides are able to influence the activity of specific proteins, among them, protein kinase
                      1. IN EFFECT PRODUCES
                        1. circulating free fatty acids constitute a pro-inflammatory stimulus, given their pro-inflammatory stimulus, given their ability to bind to membrane receptors such as TLRs.
              2. INSULIN RESISTANCE INSULIN RESISTANCE SYNDROME. STUDY AND MANAGEMENT
                1. Adipose tissue: central organ in inflammation and insulin resistance insulin resistance
                  1. ADIPOSE TISSUE
                    1. ADIPOSITE
                      1. INFLUENTIAL IN lipogenesis
                        1. HYPERTROPHIC ADIPOCYTE
                          1. has a higher lipolytic rate
                          2. BIG ADIPOCYTES
                            1. have increased synthesis and release of adipose tissue secretion products secretion products from adipose tissue
                              1. in addition, they secrete lower amounts of adiponectin, one of the few one of the few aipokines with antagonistic effects to those just described.
                                1. ALL OF THIS IS A RISK FACTOR FOR DIABETES.
                            2. IT IS ESTABLISHED THAT
                              1. the characteristics of adipose mass expansion of adipose mass will have an important influence on the development of metabolic alterations characteristic of obesity, including IR.
                                1. PATIENTS USUALLY PRESENT WITH
                                  1. increase in adipose mass concomitant with a reduction in IR.
                        2. Nutritional management of the metabolic syndrome with emphasis on insulin resistance
                          1. determining DIET IS ONE OF THE MOST COMPLEX LABORS
                            1. Excess body mass is one of the main determinants of an individual's degree of IR. degree of IR of the individual
                              1. intervention should be directed at limiting those foods that do not contribute to a healthy diet
                                1. understand the ratio of fat to carbohydrates
                                  1. under isoenergetic conditions, the effect of the effect of replacing carbohydrates with dietary fat has been evaluated.
                              2. carbohydrates
                                1. are a major component with great influence
                                  1. isolating the nutritional effect of this variable is not simple,
                                    1. since diets with low vs. high glycemic response tend to vary in content
                                2. another important aspect is
                                  1. fiber and undigested carbohydrates undigested carbohydrates in the small intestine.
                                    1. the influence of antioxidants on the control of glycemic homeostasis and insulin sensitivity. insulin sensitivity.
                                    2. It is recommended that the following values be taken into account:
                                  2. Pharmacological treatment of metabolic syndrome
                                    1. So far, no drug has shown the ability to reduce all risk factors for MS.
                                      1. the researchers concluded that the greatest chances of reversing MS are observed with diet plus exercise with diet plus exercise interventions
                                      2. Pharmacological management of insulin resistance
                                        1. the most commonly used drug is metformin.
                                          1. Metformin may be beneficial as adjunctive therapy in patients with metabolic syndrome. Metformin may be beneficial as adjunctive therapy in patients with metabolic syndrome. metabolic syndrome
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