33953370
Description
Mind Map by Santiago Felipe Cepeda Silva, updated more than 1 year ago
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Created by Santiago Felipe Cepeda Silva
over 1 year ago
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Lipid-mediated insulin resistance
- THE RI
- ASSOCIATED
WITH
- METABOLIC DISORDER
- ectopic tissue accumulation of lipids
- AMONG THEM, THE SKELETAL
MUSCLE
- EVIDENCED IN PEOPLE AND ANIMALS
- the influence of lipids on the induction of DI
- IN DIET
- HYPERCALORIC
- HYPERGRASE
- HYPERCALORIC
- HOURS LATER, THE PATIENT IS INDUCED RI
- IN DIET
- the influence of lipids on the induction of DI
- EVIDENCED IN PEOPLE AND ANIMALS
- AMONG THEM, THE SKELETAL
MUSCLE
- METABOLIC DISORDER
- DISCUSSION
- HOW DO LIPIDS ACCUMULATE IN EPTOPIC TISSUES?
- imbalance between fatty acid uptake and oxidation of fatty acids
- ALLOWING
- accumulation in cells of specific tissues..
- HOWEVER
- individuals with IR tend to be characterized by lower mitochondrial density and ATP synthesis in skeletal muscle.
synthesis in skeletal muscle
- IT IS PROPOSED THAT
- existence of mitochondrial dysfunction in skeletal muscle of individuals with skeletal muscle of individuals with IR
- AGREEING
THAT
- the determinants of ectopic lipid ectopic lipid accumulation, particularly at the level of skeletal muscle, is an area of
intense study. skeletal muscle correspond to an area of intense study.
- the determinants of ectopic lipid ectopic lipid accumulation, particularly at the level of skeletal muscle, is an area of
intense study. skeletal muscle correspond to an area of intense study.
- AGREEING
THAT
- existence of mitochondrial dysfunction in skeletal muscle of individuals with skeletal muscle of individuals with IR
- IT IS PROPOSED THAT
- individuals with IR tend to be characterized by lower mitochondrial density and ATP synthesis in skeletal muscle.
synthesis in skeletal muscle
- HOWEVER
- accumulation in cells of specific tissues..
- ALLOWING
- imbalance between fatty acid uptake and oxidation of fatty acids
- to how lipids interfere with insulin signaling. insulin signaling?
- KNOWN
- diglycerides are able to influence the activity of specific proteins, among them, protein kinase
- IN EFFECT PRODUCES
- circulating free fatty acids constitute a pro-inflammatory stimulus, given their pro-inflammatory stimulus, given their
ability to bind to membrane receptors such as TLRs.
- circulating free fatty acids constitute a pro-inflammatory stimulus, given their pro-inflammatory stimulus, given their
ability to bind to membrane receptors such as TLRs.
- IN EFFECT PRODUCES
- diglycerides are able to influence the activity of specific proteins, among them, protein kinase
- KNOWN
- HOW DO LIPIDS ACCUMULATE IN EPTOPIC TISSUES?
- ASSOCIATED
WITH
- INSULIN RESISTANCE INSULIN RESISTANCE SYNDROME. STUDY AND MANAGEMENT
- Adipose tissue: central organ in inflammation and insulin resistance insulin resistance
- ADIPOSE
TISSUE
- ADIPOSITE
- INFLUENTIAL IN lipogenesis
- HYPERTROPHIC ADIPOCYTE
- has a higher lipolytic rate
- has a higher lipolytic rate
- BIG ADIPOCYTES
- have increased synthesis and release of adipose tissue secretion products secretion products from adipose tissue
- in addition, they secrete lower amounts of adiponectin, one of the few one of the few aipokines with antagonistic effects
to those just described.
- ALL OF THIS IS A RISK FACTOR FOR
DIABETES.
- ALL OF THIS IS A RISK FACTOR FOR
DIABETES.
- in addition, they secrete lower amounts of adiponectin, one of the few one of the few aipokines with antagonistic effects
to those just described.
- have increased synthesis and release of adipose tissue secretion products secretion products from adipose tissue
- IT IS ESTABLISHED THAT
- the characteristics of adipose mass expansion of adipose mass will have an important influence on the development of
metabolic alterations characteristic of obesity, including IR.
- PATIENTS USUALLY PRESENT WITH
- increase in adipose mass concomitant with a
reduction in IR.
- increase in adipose mass concomitant with a
reduction in IR.
- PATIENTS USUALLY PRESENT WITH
- the characteristics of adipose mass expansion of adipose mass will have an important influence on the development of
metabolic alterations characteristic of obesity, including IR.
- INFLUENTIAL IN lipogenesis
- ADIPOSITE
- ADIPOSE
TISSUE
- Nutritional management of the metabolic syndrome with emphasis on insulin resistance
- determining DIET IS ONE OF THE MOST COMPLEX LABORS
- Excess body mass is one of the main determinants of an individual's degree of IR. degree of IR of the individual
- intervention should be directed at limiting those foods that do not contribute to a healthy diet
- understand the ratio of fat to
carbohydrates
- under isoenergetic conditions, the effect of the effect of replacing carbohydrates with dietary fat has been evaluated.
- under isoenergetic conditions, the effect of the effect of replacing carbohydrates with dietary fat has been evaluated.
- understand the ratio of fat to
carbohydrates
- intervention should be directed at limiting those foods that do not contribute to a healthy diet
- carbohydrates
- are a major component with great
influence
- isolating the nutritional effect of this variable is not simple,
- since diets with low vs. high glycemic response tend to vary in content
- since diets with low vs. high glycemic response tend to vary in content
- isolating the nutritional effect of this variable is not simple,
- are a major component with great
influence
- another important aspect is
- fiber and undigested carbohydrates undigested
carbohydrates in the small intestine.
- the influence of antioxidants on the control of glycemic homeostasis and insulin sensitivity. insulin sensitivity.
- fiber and undigested carbohydrates undigested
carbohydrates in the small intestine.
- It is recommended that the following values be taken into account:
- Excess body mass is one of the main determinants of an individual's degree of IR. degree of IR of the individual
- determining DIET IS ONE OF THE MOST COMPLEX LABORS
- Pharmacological treatment of metabolic syndrome
- So far, no drug has shown the ability to reduce all risk factors for MS.
- the researchers concluded that the greatest chances of reversing MS are observed with diet plus
exercise with diet plus exercise interventions
- the researchers concluded that the greatest chances of reversing MS are observed with diet plus
exercise with diet plus exercise interventions
- Pharmacological management of insulin resistance
- the most commonly used drug is metformin.
- Metformin may be beneficial as adjunctive therapy in patients with metabolic syndrome. Metformin
may be beneficial as adjunctive therapy in patients with metabolic syndrome. metabolic syndrome
- Metformin may be beneficial as adjunctive therapy in patients with metabolic syndrome. Metformin
may be beneficial as adjunctive therapy in patients with metabolic syndrome. metabolic syndrome
- the most commonly used drug is metformin.
- So far, no drug has shown the ability to reduce all risk factors for MS.
- Adipose tissue: central organ in inflammation and insulin resistance insulin resistance
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