Copy and Edit

Toxicology

Description

Key Terms relationships
Linda Salas
Mind Map by Linda Salas, updated more than 1 year ago
Linda Salas
Created by Linda Salas over 10 years ago
11
0
0

Resource summary

Toxicology
  1. absorption
    1. Body parts CHIP
      1. adipose tissue
        1. chronic exposure
          1. bioaccumulation
            1. Acute
              1. Toxin/toxic dose
                1. BT
                  1. Benzene
                    1. Carcinogenesis
                      1. Apoptosis
                        1. Cell viability
                          1. Free radicals
                              1. Histidine/Cysteine/Thiol/Glutathione
                                2. Oxidative Stress
                                  1. ROS,RNS,OH-,H2O2
                                    1. Savengers
                                      1. Antioxidants
                                        1. BHA,BHT
                                  2. Paracelsus
                                    1. Dose
                                      1. Dose-Response
                                        1. Drug Eficacy
                                            1. ED50
                                            2. Drug safety
                                                1. LD50
                                                    1. Mycotoxin
                                                      1. Aflatoxin
                                                        1. Coffe/Choco
                                                        2. Ochratoxin
                                                      2. Thalidomide
                                                        1. Teratogenesis
                                                          1. Reproductive Studies
                                                            1. Phytoestrogens
                                                              2. Bisphenol A
                                                          2. Hormesis
                                                            1. Pharmacokinetic Curve
                                                              1. Therapeutic dose
                                                                  1. Linearity
                                                                  2. Sigmoidal Curve LD50/ED50/TD50
                                                                      1. Concentration units
                                                                        1. LOAEL,NOAEL, TD50
                                                                        2. J shaped, U shaped
                                                                          1. TOXIN
                                                                            1. Exposure/Risk Assessment
                                                                              1. Detministic Models
                                                                                    1. Margin Safety
                                                                                      1. Max TOlerable Daily Dose
                                                                                      2. Detection limits
                                                                                        1. Hazard ID
                                                                                            1. Hazard identification
                                                                                              1. Probabilistic Models
                                                                                                1. Qualitative Models
                                                                                                  1. Risk Characterization
                                                                                                    1. Riskiest Foods (frequency)
                                                                                                      1. Uncertainty
                                                                                                          1. Enviornmental toxicology
                                                                                                            1. Xenobiotic
                                                                                                              1. Generational Studies
                                                                                                                2. Pesticide
                                                                                                                  1. Narcotic
                                                                                                                    1. Methamphetamine
                                                                                                                    2. Neurotoxin
                                                                                                                      1. malathion
                                                                                                                        1. Acetylcholinesterase Inhibitors
                                                                                                                      2. Observational Study
                                                                                                                        1. Herbicide
                                                                                                                        2. Heavy Metals
                                                                                                                          1. Arsenic
                                                                                                                            1. Dermal exposure/skin
                                                                                                                              2. Pinal de Amoles
                                                                                                                                1. LED lights
                                                                                                                                  1. Deposition
                                                                                                                                    1. Finger Nails
                                                                                                                                      1. Hair
                                                                                                                                        1. Ion Chanels
                                                                                                                                          1. ion exchange
                                                                                                                                          2. Cations
                                                                                                                                            1. Lead
                                                                                                                                              1. Neurotoxin?
                                                                                                                                                1. Mercury/ron
                                                                                                                                                2. Sugar
                                                                                                                                                  1. Millard Browning
                                                                                                                                                    1. Diabetes
                                                                                                                                                      1. Type I,II
                                                                                                                                                      2. Acrylamide
                                                                                                                                                      1. ethanol
                                                                                                                                                        1. PO exposure
                                                                                                                                                        2. Quorum Sensing
                                                                                                                                                          1. Microbial Flora
                                                                                                                                                            1. Synergistic
                                                                                                                                                            2. Staph Au Toxin
                                                                                                                                                            3. Harm
                                                                                                                                                              1. CELL RESPIRATION INHIBITORS
                                                                                                                                                                1. Narcosis
                                                                                                                                                                1. IV exposure
                                                                                                                                                                2. bioavailability
                                                                                                                                                                    1. CYP450
                                                                                                                                                                      1. Cytotoxicity
                                                                                                                                                                          1. Grapefruit
                                                                                                                                                                            1. Liver
                                                                                                                                                                              1. Potentiation
                                                                                                                                                                                1. Benzopyrene
                                                                                                                                                                                  1. Genotoxicity
                                                                                                                                                                                  2. Xenobiotic metabolism
                                                                                                                                                                                  3. Elimination
                                                                                                                                                                                    1. Excretion routes
                                                                                                                                                                                      1. Biliary
                                                                                                                                                                                        1. Feces
                                                                                                                                                                                        2. Kidney/Renal
                                                                                                                                                                                          1. Nephrotoxin
                                                                                                                                                                                            1. Urine
                                                                                                                                                                                            2. Sweat
                                                                                                                                                                                              1. Ph III Enzyme
                                                                                                                                                                                              2. Digestibility
                                                                                                                                                                                                1. PhII Enzyme
                                                                                                                                                                                                  1. Lipophylic
                                                                                                                                                                                                  2. PhI Enzyme
                                                                                                                                                                                                    1. POLAR/NON
                                                                                                                                                                                                    2. Xenobiotic metabolism
                                                                                                                                                                                                    3. Entreohepatic Circulation
                                                                                                                                                                                                      1. hepatotoxin
                                                                                                                                                                                                        1. Necrosis
                                                                                                                                                                                                      2. Bone
                                                                                                                                                                                                          1. Chelators
                                                                                                                                                                                                                1. EDTA, desferroxiamine, D-penicillamine,BAL
                                                                                                                                                                                                                      1. Anions
                                                                                                                                                                                                                        1. Antioxidants
                                                                                                                                                                                                                          1. Neutral charged, Covalent bonds
                                                                                                                                                                                                                            1. Side effects,specificity, toxin re-distribution
                                                                                                                                                                                                                              1. Hydrophilic chelators
                                                                                                                                                                                                                                1. mono/bi/polidentate
                                                                                                                                                                                                                                  1. Iron can be a
                                                                                                                                                                                                                                    1. Combination Therapy
                                                                                                                                                                                                                                      1. lipophilic
                                                                                                                                                                                                                                      2. D
                                                                                                                                                                                                                                2. Subchronic
                                                                                                                                                                                                                                  1. Dioxin
                                                                                                                                                                                                                                  2. Allergy
                                                                                                                                                                                                                                    1. Animal testing/in vivo
                                                                                                                                                                                                                                          1. TESTING ALTERNATIVES
                                                                                                                                                                                                                                            1. Ex Vivo
                                                                                                                                                                                                                                              1. in vitro
                                                                                                                                                                                                                                                  1. immortalized cells
                                                                                                                                                                                                                                                    1. Caco2-cells
                                                                                                                                                                                                                                                  2. in silico
                                                                                                                                                                                                                                                    1. in vivo: humans
                                                                                                                                                                                                                                                      1. METHODS
                                                                                                                                                                                                                                                        1. ELISA
                                                                                                                                                                                                                                                          1. HTS
                                                                                                                                                                                                                                                            1. Acuracy, Precision/Replicate, Probability/Risk, Randomized, Robustness, blocking
                                                                                                                                                                                                                                                              1. Sensitivity,supernatant, Validation,standard spiking, controls+,-,0)
                                                                                                                                                                                                                                                                1. Western blot
                                                                                                                                                                                                                                                                  1. Tylenol/acetominophen
                                                                                                                                                                                                                                                                    1. Example1: Theobromine in Chocolate
                                                                                                                                                                                                                                                                      1. HPLC
                                                                                                                                                                                                                                                                        1. CH3OH
                                                                                                                                                                                                                                                                        2. Area under the curve
                                                                                                                                                                                                                                                                          1. Methylxantine psycoactive adenosin receptor blocker
                                                                                                                                                                                                                                                                            1. Theobromine
                                                                                                                                                                                                                                                                            2. pHENYLETHYLAMINE
                                                                                                                                                                                                                                                                            3. Example 2: Flavonoid ROS Scavenger+
                                                                                                                                                                                                                                                                              1. Inflamation
                                                                                                                                                                                                                                                                                1. Flavonoids
                                                                                                                                                                                                                                                                                  1. Aspirin
                                                                                                                                                                                                                                                                                    1. Acetominophen
                                                                                                                                                                                                                                                                                  2. Blood pressure
                                                                                                                                                                                                                                                                                    1. Prostaglandin
                                                                                                                                                                                                                                                                                      1. Cyclooxygenase productor
                                                                                                                                                                                                                                                                                      2. RAW 264.7 Cells
                                                                                                                                                                                                                                                                                  3. HACCP
                                                                                                                                                                                                                                                                                  2. Case study
                                                                                                                                                                                                                                                                                      1. Clinical toxicology
                                                                                                                                                                                                                                                                                          2. Clinical studies
                                                                                                                                                                                                                                                                                            1. Animal CvsR
                                                                                                                                                                                                                                                                                              1. PhI
                                                                                                                                                                                                                                                                                                1. PhII
                                                                                                                                                                                                                                                                                                  1. PhIII
                                                                                                                                                                                                                                                                                                    2. PhIV
                                                                                                                                                                                                                                                                                                    1. Regulatory, Forensic
                                                                                                                                                                                                                                                                                                      Show full summary Hide full summary

                                                                                                                                                                                                                                                                                                      Want to create your own Mind Maps for free with GoConqr? Learn more.

                                                                                                                                                                                                                                                                                                      Similar

                                                                                                                                                                                                                                                                                                      Toxicology MCQs- 3rd Year- PMU
                                                                                                                                                                                                                                                                                                      Med Student
                                                                                                                                                                                                                                                                                                      Royal Blue Topped Tubes
                                                                                                                                                                                                                                                                                                      Pip Fraggle
                                                                                                                                                                                                                                                                                                      Toxicology Review
                                                                                                                                                                                                                                                                                                      kwoodard_gcems
                                                                                                                                                                                                                                                                                                      Pesticides
                                                                                                                                                                                                                                                                                                      mlaavoie
                                                                                                                                                                                                                                                                                                      Toxicology haemodialysis/perfusion indications
                                                                                                                                                                                                                                                                                                      snough
                                                                                                                                                                                                                                                                                                      Cardiovascular toxicology
                                                                                                                                                                                                                                                                                                      Alice Kermond
                                                                                                                                                                                                                                                                                                      Toxicology
                                                                                                                                                                                                                                                                                                      Fatin Nabilah Roslaile
                                                                                                                                                                                                                                                                                                      Toxicological Test
                                                                                                                                                                                                                                                                                                      Juan Pedro Rosito Garcia
                                                                                                                                                                                                                                                                                                      Forensics
                                                                                                                                                                                                                                                                                                      Matthew Orr
                                                                                                                                                                                                                                                                                                      Browse Library