The Blood-Brain Barrier

IMA HUSS
Mind Map by IMA HUSS, updated more than 1 year ago
IMA HUSS
Created by IMA HUSS about 4 years ago
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The blood-brain barrier
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The Blood-Brain Barrier
1 Purpose?
1.1 - Minimize the risk of irreplaceable brain damage - keep out most viruses, bacteria, and harmful chemicals
1.1.1 However!
1.1.1.1 ¥ Some viruses do cross the Blood-brain barrier
1.1.1.1.1 What Happen then?
1.1.1.1.1.1 - Rabies virus invades the barrier -> infection -> death - Syphilis-> long lasting consequence
1.1.1.1.1.1.1 What can Microglia do ?
1.1.1.1.1.1.1.1 - It is effective against certain other viruses. - Increase inflammatory responses -> fight a virus w/o killing the neuron.
1.1.1.1.1.1.1.1.1 However!
1.1.1.1.1.1.1.1.1.1 This response may control the virus without eliminating it. Chicken pox virus enters spinal cored -> remain there long after they have been destroyed -> the virus may emerge decades later -> shingles.
2 How does it work?
2.1 Depends on Endothelial Cells
2.1.1 outside the brain: separated by small gaps
2.1.2 in the brain: joined so tightly that they block viruses, bacteria and other harmful chemicals
3 Why we don't have similar walls around all other organs?
3.1 - the barrier block useful chemical as well as harmful ones. - useful chemical include all fuels and normal flora, amino acids, the building blocks for proteins
3.1.1 How the useful chemical enters the brain?
3.1.1.1 protein channels for H2O crossing
3.1.1.2 small, uncharged molecules cross freely (O2, Co2)
3.1.1.3 Active transport: a protein-mediated process that use up energy to pump chemicals from the blood into the brain (e.g. Glucose, amino acids, purines, choline, a few vitamins, irons, and certain hormones
3.1.1.4 Dissolvant molecules in the fats of the membrane cross easily, (e.g. Vitamins A and D, all drugs that effect the brain.
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