1.1 - Minimize the risk of irreplaceable brain damage
- keep out most viruses, bacteria, and harmful
18.104.22.168 ¥ Some viruses do cross the Blood-brain
22.214.171.124.1 What Happen then?
126.96.36.199.1.1 - Rabies virus invades the barrier -> infection -> death
- Syphilis-> long lasting consequence
188.8.131.52.1.1.1 What can Microglia do ?
184.108.40.206.220.127.116.11 - It is effective against certain other viruses. - Increase inflammatory
responses -> fight a virus w/o killing the neuron.
18.104.22.168.22.214.171.124.1.1 This response may control the virus without eliminating it.
Chicken pox virus enters spinal cored -> remain there long after
they have been destroyed -> the virus may emerge decades later
2 How does it work?
2.1 Depends on Endothelial Cells
2.1.1 outside the brain: separated by small gaps
2.1.2 in the brain: joined so tightly that they block
viruses, bacteria and other harmful chemicals
3 Why we don't have similar walls around all other organs?
3.1 - the barrier block useful chemical as well
as harmful ones. - useful chemical include
all fuels and normal flora, amino acids, the
building blocks for proteins
126.96.36.199 Active transport: a protein-mediated process that
use up energy to pump chemicals from the blood
into the brain (e.g. Glucose, amino acids, purines,
choline, a few vitamins, irons, and certain
188.8.131.52 Dissolvant molecules in the fats of the membrane
cross easily, (e.g. Vitamins A and D, all drugs that
effect the brain.