Therapeutic Drug Monitoring

jenny schneider
Mind Map by jenny schneider, updated more than 1 year ago
jenny schneider
Created by jenny schneider almost 7 years ago
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university Pharmacokinetics Mind Map on Therapeutic Drug Monitoring, created by jenny schneider on 01/19/2014.
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Therapeutic Drug Monitoring
1 Assay techniques
1.1 Assays using antibodies
1.1.1 FPIA, RIA, EMIT
1.1.2 Advantages: rapid, less training, small sample size
1.1.3 Disadvantages: less specific (cross-react)
1.2 chromatography techniques
1.2.1 GC, HPLC
1.2.2 Advantages: better specificity; good for research applications
1.2.3 Disadvantages: equipment costly, needs bigger sample size, not as quick as antibody methods, need more training
2 Blood Sampling
2.1 correct time- usually trough level
2.2 correct type of tube
2.3 correct handling and storage
3 Assay requirements
3.1 Reproducible, accuracy and precision
4 Interpreting TDM result clinically
4.1 look at result AND patient response
4.2 Consider patient factors- e.g. disease, age
4.3 consider assay used and sample collection/handling
4.4 sample taken at correct time?
4.5 what is dosage regimen and when last dose was taken
5 good candidate for TDM
5.1 good correlation between concentration and effect
5.2 therapeutic range defined
5.3 narrow therapeutic index
5.4 large interindividual variability
5.5 effect cannot be measured by simpler method
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