Biological approach to explaining OCD (GENETIC)

Jess Hughes
Mind Map by , created over 3 years ago

AS - Level Psychology (Psychopathology) Mind Map on Biological approach to explaining OCD (GENETIC), created by Jess Hughes on 05/04/2016.

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Jess Hughes
Created by Jess Hughes over 3 years ago
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Biological approach to explaining OCD (GENETIC)
1 COMT gene
1.1 Involved in production of catechol - O -methyltransferase
1.2 Regulates production of neurotransmitter - DOPAMINE
1.3 One allele of the gene has been found to be more abundant in those with OCD
1.3.1 This allele produces lower activity of COMT gene and higher levels of dopamine
2 SERT gene
2.1 Affects transport of SEROTONIN, creating lower levels of the neurotransmitter
2.2 One study found a mutation of the gene in 2 unrelated families and 6/7 had OCD
3 DIATHESIS - STRESS
3.1 Each individual gene ONLY creates a vulnerability (diathesis) for OCD as well as other conditons, i.e. depression and PTSD
3.2 Other factors (stressors) affect what condition develops
3.3 So someone could have the COMT and SERT genes but no ill effects
4 Family and twin studies
4.1 80 patients with OCD and 343 of their first degree relatives were compared to 73 people without mental illness and 300 of their first degree relatives
4.1.1 Found people with a first degree relative with OCD have a 5X greater chance of having the illness at some point.
4.2 Meta analysis of 14 twin studies found on average MZ twins were over 2X likely to develop OCD if 1 twin had the disorder

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