On September 13, 1848 a then 25-year
old Gage suffered a traumatic brain injury
when an iron rod was driven through his
skull, destroying much of his frontal lobe.
Gage survived the accident, but
was so changed as a result that
many of his friends described him
as a different man entirely.
Almost a month later, Harlow, Gage's doctor
noted that his intellectual functioning began to
improve, he noted that Gage knew how much time
had passed since the accident and remembered
clearly how the accident occurred.
But he had difficulty estimating size and amounts of money.
When Harlow saw Gage again the
following year, he noted how Gage
seemed to be in good physical
health and appeared recovered.
It was said that before the accident Gage was a
hardworking and pleasant man. Post-accident he was
described as a changed man, suggesting that the
injury had changed him into a surly, aggressive
drunkard who was unable to hold down a job.
Harlow's accounts suggest that the injury did lead
to a loss of social inhibition, leading Gage to
behave in ways that were seen as inappropriate.
In a 1994 study researchers utilized neuroimaging
techniques to reconstruct Gage's skull and determine the
exact placement of the injury. Their findings indicate that
he suffered injury to both the left and right pre-frontal
cortices, which would result in problems with emotional
processing and rational decision making.
Another study conducted in 2004
that involved using
three-dimensional, computer
aided reconstruction to analyse
the extent of Gage's injury, and
found that the effects were limited
to the left frontal lobe.