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Rheumatoid Arthritis

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Mind Map on Rheumatoid Arthritis, created by richbrown92 on 05/29/2014.
richbrown92
Mind Map by richbrown92, updated more than 1 year ago
richbrown92
Created by richbrown92 almost 11 years ago
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Resource summary

Rheumatoid Arthritis
  1. Aetiology
    1. HLA DR4
      1. 50% Genetic
        1. 50% Environmental
        2. Prevelance
          1. Female>Male
          2. Pathology
            1. T-Cells
              1. TNF-a
                1. Inflammation
                  1. Attract other immune cells
                    1. Synovial fluid production
                      1. Cartilage destruction
                        1. Bone reabsorption
                          1. Increase antibody product - rheumatoid factor
                          2. IL-1
                          3. Rheumatoid factor in serum of 80% of patients
                            1. Pannus
                              1. Erosion + deformity
                            2. Features
                              1. Articular
                                1. Early morning stiffness
                                  1. Monoarthritis Occasionally
                                    1. Palindromic rheumatism
                                      1. Swelling
                                        1. Pain
                                          1. Boggy Sinovitis
                                            1. Hand
                                              1. DIP Sparing
                                                1. Ulnar deviation
                                                  1. MCP Subluxation
                                                    1. Boutonnieres + Swan Neck
                                                      1. Prominent Ulnar styloid
                                                      2. Foot
                                                        1. Forefoot synovitis
                                                          1. Dorsal subluxation of proximal phalanges
                                                          2. Cervical Spine
                                                          3. Extra Articular
                                                            1. Rheumatoid Nodules
                                                              1. Tenosynovitis + Bursitis
                                                                1. Carpel Tunnel
                                                                  1. Anaemia
                                                                    1. Felty's syndrome
                                                                      1. Splenomegaly
                                                                        1. Leucopenia
                                                                          1. Rheumatoid factor +ve
                                                                          2. Lung Disease
                                                                            1. Pleural Effusions
                                                                            2. Cardia disease
                                                                              1. Pericardial Inflammation
                                                                                1. Pericardial Effusion
                                                                                2. Eye Disease
                                                                                  1. Keratoconjunctivitis
                                                                                    1. Dry eyes
                                                                                    2. Amyloidosis
                                                                                      1. Kidneys
                                                                                        1. Proteinuria
                                                                                        2. Heart
                                                                                        3. Vasculitis
                                                                                      2. Management
                                                                                        1. Anti CCP antibodies
                                                                                          1. X-Ray
                                                                                            1. Soft Tissue Swelling
                                                                                              1. Periarticular Osteoporosis
                                                                                                1. Juxta-articular erosions
                                                                                                  1. Narrowing joint spaces
                                                                                                  2. NSAIDS
                                                                                                    1. Corticosteroids
                                                                                                      1. DMARDS
                                                                                                        1. Azothioprine
                                                                                                          1. Gi upset
                                                                                                            1. Bone Marrow Suppresion
                                                                                                            2. Methotrexate
                                                                                                              1. GI upset
                                                                                                                1. Oral Ulcer
                                                                                                                  1. Raised liver enzymes
                                                                                                                    1. Bone Marrow Suppresion
                                                                                                                    2. Cyclophosphamide
                                                                                                                      1. Infertility
                                                                                                                        1. Increased Risk of Malignancy
                                                                                                                        2. Hydroxychloroquine
                                                                                                                          1. Retinal Damage
                                                                                                                        3. Biologics
                                                                                                                          1. Anti-TNF
                                                                                                                            1. Etanercept
                                                                                                                              1. Soluble TNF receptor
                                                                                                                              2. Infliximab
                                                                                                                                1. Monoclonal antibodiy
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