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969398
Cell Junctions
Description
Mind Map on Cell Junctions, created by devans1 on 06/04/2014.
Mind Map by
devans1
, updated more than 1 year ago
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Created by
devans1
over 10 years ago
21
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Resource summary
Cell Junctions
tight junctions
semi fusion
local connections between plasma mem
stop leakage
aka occulding junctions
leaky
paracellular transport
continuous apical band
freeze fracture - structure
Claudin
link to actin
anchoring
internal support
structure
proteins through bilayer
claudin
occludin
link to actin
Gap junctions
dont semi fuse
connect cytoplasms
low resistant channels/pores
belts
heart/smooth muscle/neurons
belt desmosomes
actin associated and motor protein
contractile actin rings tighten/slacken
reshaping tissues
invagination forming neural tube
multiple cadherins
electrochemical AP move through
charged ions
IP3,ATP, AA, cAMP intracell messengers
no proteins mRNA
structure
aqueous pore
2 connexons line
made of 6 connexins/innexins
hetero/homomeric
heter/homotypic
1000 mw fits through
1.5nm diametre
intracellular channel
opening/closing
pH, Ca2+, signalling mols
retina
gap junctions in neurons leaks dye
closing
dopamine
Ca2+
too much is toxic
importance of junctions
Pemphigus
autoimmune disease
skin blisters
desmoglein foreign (cadherin)
weakened junctions
Desmosomes
homophilic interactions
with intermediate filaments
and cadherins
Hemidesmosomes
to basal lamina
laminin (integrin)
focal adhesions with extracellular matrix
with actin
cell adhesion molecules
between cells
immunoglobins - weak
non Ca2+/Mg2+ dependent
cadherin - strong
Adherins junctions
adhesion molecules on cell surface
calcium dependant cadherin
homophillic interactions
dimers
to anchor proteins
to actin filaments
catenins - molecules that express cadherin
bundles
adhesion belts
E type = embryonic/epithelial
cytoplasmic plaque
intracellular anchor proteins
keratin filaments
desmosomes
anchored to cytoplasmic plaque
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