Cell Junctions

Description

Mind Map on Cell Junctions, created by devans1 on 06/04/2014.
devans1
Mind Map by devans1, updated more than 1 year ago
devans1
Created by devans1 over 10 years ago
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Resource summary

Cell Junctions
  1. tight junctions
    1. semi fusion
      1. local connections between plasma mem
      2. stop leakage
        1. aka occulding junctions
          1. leaky
            1. paracellular transport
            2. continuous apical band
              1. freeze fracture - structure
                1. Claudin
                  1. link to actin
                    1. anchoring
                      1. internal support
                  2. structure
                    1. proteins through bilayer
                      1. claudin
                        1. occludin
                          1. link to actin
                      2. Gap junctions
                        1. dont semi fuse
                          1. connect cytoplasms
                          2. low resistant channels/pores
                            1. belts
                              1. heart/smooth muscle/neurons
                                1. belt desmosomes
                                  1. actin associated and motor protein
                                    1. contractile actin rings tighten/slacken
                                      1. reshaping tissues
                                        1. invagination forming neural tube
                                  2. multiple cadherins
                                  3. electrochemical AP move through
                                    1. charged ions
                                      1. IP3,ATP, AA, cAMP intracell messengers
                                        1. no proteins mRNA
                                      2. structure
                                        1. aqueous pore
                                          1. 2 connexons line
                                            1. made of 6 connexins/innexins
                                              1. hetero/homomeric
                                                1. heter/homotypic
                                                2. 1000 mw fits through
                                                  1. 1.5nm diametre
                                                    1. intracellular channel
                                                    2. opening/closing
                                                      1. pH, Ca2+, signalling mols
                                                        1. retina
                                                          1. gap junctions in neurons leaks dye
                                                          2. closing
                                                            1. dopamine
                                                              1. Ca2+
                                                                1. too much is toxic
                                                          3. importance of junctions
                                                            1. Pemphigus
                                                              1. autoimmune disease
                                                                1. skin blisters
                                                                  1. desmoglein foreign (cadherin)
                                                                    1. weakened junctions
                                                            2. Desmosomes
                                                              1. homophilic interactions
                                                                1. with intermediate filaments
                                                                  1. and cadherins
                                                                2. Hemidesmosomes
                                                                  1. to basal lamina
                                                                    1. laminin (integrin)
                                                                      1. focal adhesions with extracellular matrix
                                                                    2. with actin
                                                                    3. cell adhesion molecules
                                                                      1. between cells
                                                                        1. immunoglobins - weak
                                                                          1. non Ca2+/Mg2+ dependent
                                                                          2. cadherin - strong
                                                                        2. Adherins junctions
                                                                          1. adhesion molecules on cell surface
                                                                            1. calcium dependant cadherin
                                                                              1. homophillic interactions
                                                                                1. dimers
                                                                                  1. to anchor proteins
                                                                                    1. to actin filaments
                                                                                      1. catenins - molecules that express cadherin
                                                                                        1. bundles
                                                                                          1. adhesion belts
                                                                                    2. E type = embryonic/epithelial
                                                                                    3. cytoplasmic plaque
                                                                                      1. intracellular anchor proteins
                                                                                        1. keratin filaments
                                                                                          1. desmosomes
                                                                                            1. anchored to cytoplasmic plaque
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