Lincomycins, Polypeptides, Unclassified Antibiotics and Newer Antibiotics

sulfur-containing antibiotics

bacteriostatic / bactericidal - depending on the concentration; binds at 50s; inhibit protein synthesis

structure of Lincomycin HCl

side effect of lincomycin

S/E of clindamycin

IV or IM when oral administration is not feasible

p 315

glycopeptide antibiotic S. orientalis

a glycopeptide antibiotic that is a tx for endocarditis by gram positive

a glycopeptide antibiotic that is a tx for endocarditis by gram positive

always IV never IM

S/E of Vancomycin

a mixture of five closely related glycopeptide antibiotics produced by the actinomycete Actinoplanes teichomyceticus.

Teicoplanin MOA

source of teicoplanin

source of bacitracin

it is a complex
mixture of polypeptides; bactericidal action is enhanced by zinc; inhibit mucopeptide cell wall synthesis

causes less kidney damage than to others

source of colistin sulfate

forms of colistin (2)

sulfate
methanesulfonate

source of gramicidin

brand name

components of Tyrothricin

gramicidin - more active component of tyrothricin; ionophone

source of chloramphenicol

prodrug of chloramphenicol intended for pediatric use.

brand name and source of Mupirocin

it is a combination of the streptogramin B quinupristin with the streptogramin A dalfopristin in a 30:70 ratio.

brand name

source of Quinupristin/dalfopristin

an oxazolidinedione-type antibacterial agent that inhibits bacterial protein synthesis

brand name

a first-in-class (a glycylcycline) in- travenous antibiotic

source of Aztreonam

a synthetic 1-beta-methyl carbapenem that is structurally related to beta-lactam antibiotics, particularly the thienamycin group

orally bioavailable macrolide

brandname

source of platensimycin

a new structural class of antibiotics with very po- tent broad-spectrum activity against Gram-positive bacteria.