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Quiz on MICR223 Innate Immunity, created by ruby.white94 on 03/10/2013.

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MICR223 Innate Immunity

MICR223 Innate Immunity

Question 1 of 28

1

What is involved in distinguishing between dangerous and non dangerous pathogens?

Select one of the following:

  • Inflammasome

  • NLRs

  • Both

  • Neither

Explanation

Question 2 of 28

1

What is a PAMP?

Select one of the following:

  • Pathogen association membrane proteins

  • Protein assisted molecular pathway

  • Pathogen associated molecular patterns

  • Pathogen antigen model patterns

Explanation

Question 3 of 28

1

What does a PRR do?

Select one or more of the following:

  • Transport proteins around the cell

  • Produces cytokines directly

  • Affects gene transcription

  • Recognises pathogen patterns

  • Starts a signalling pathway

Explanation

Question 4 of 28

1

Which of the following is incorrect about PAMPS

Select one of the following:

  • Flagellin is the PAMP for flagellated bacteria

  • Lipolysaccharides is the PAMP for Gram -ve bacteria

  • Peptidoglycan is also a PAMP for Gram -ve bacteria

  • Zymosan is the PAMP for fungi

  • ssRNA a PAMP for viral infection

Explanation

Question 5 of 28

1

What makes an ideal PAMP?

Select one of the following:

  • Something heavy in lipids

  • Something that is fundemental to the cells function

  • Toxins

  • Self antigen.

Explanation

Question 6 of 28

1

What makes an ideal PAMP?

Select one of the following:

  • Something heavy in lipids

  • Something that is fundemental to the cells function

  • Toxins

  • Self antigen.

Explanation

Question 7 of 28

1

Why must we have a signal for pathogen vs self as well as for dangerous vs non dangerous?

Select one or more of the following:

  • Because if we react to self antigen our immune system attacks our own bodies

  • Because many of the organisms in our body are commensals and killing them could lead to opportunistic infections

  • Because two signals allow are more controlled reaction

  • So that if you get one signal and not the other only a small or no response occurs. Minimises damage.

Explanation

Question 8 of 28

1

Why must we have a signal for pathogen vs self as well as for dangerous vs non dangerous?

Select one or more of the following:

  • Because if we react to self antigen our immune system attacks our own bodies

  • Because many of the organisms in our body are commensals and killing them could lead to opportunistic infections

  • Because two signals allow are more controlled reaction

  • So that if you get one signal and not the other only a small or no response occurs. Minimises damage.

Explanation

Question 9 of 28

1

Which are incorrect?

Select one or more of the following:

  • C-type lectin receptors detect fungal antigen

  • RIG-1 like Receptors recognise protozoan antigen

  • Toll like receptors recognise bacterial antigen

  • NOD- like receptors recognise only bacterial antigen

Explanation

Question 10 of 28

1

What receptors recognise Candida? and what does it lead to?

Select one or more of the following:

  • Dectin-1 Th17 adaptive immune response

  • Dectin-2 Th17 adaptive immune response

  • Mannose receptors Th17 adaptive immune response

Explanation

Question 11 of 28

1

What does mincle recognise?

Select one of the following:

  • Bacillius subtilis

  • Malassezia spp and trehalose dimycolate from M.tuberculosis.

  • Clostridium spp C.difficile, C.tetani and C.botulinum

  • Protozoa

Explanation

Question 12 of 28

1

What is the outcome of TLR signalling?

Select one of the following:

  • Inflammatory cytokines

  • T cell stimulating cytokines

  • Anti inflammatory cytokines

Explanation

Question 13 of 28

1

Which is incorrect?

Select one of the following:

  • RLRs signal outcomes are inflammatory cytokines esp IFNs

  • CLRs Signal outcomes are Tcell stimulating cytokines esp IL-17

  • NLRs signal outcomes are Inflammatory cytokines IL-2

Explanation

Question 14 of 28

1

Where do you find NOD like receptors?

Select one of the following:

  • In a vesicle

  • In the cytosol

  • In the membrane

  • In the lymph node

Explanation

Question 15 of 28

1

Which is correct?

Select one or more of the following:

  • NOD1 recognises G -ve bacteria

  • NOD2 recognises all bacteria

  • NOD proteins recognise danger and viruses

  • There is more NOD in epithelial cells

  • NOD is also in APCs

  • NOD2 recognises only gram +ve bacteria

  • NOD1 recognises fungi

  • Nod proteins recognise danger and protozoa

Explanation

Question 16 of 28

1

Which of these are acute inflammatory cytokines?

Select one of the following:

  • IL-1, IL-7, IL-17

  • IL-1, IL-8, IL-18

  • IL-1, IL-2, IL17

  • IL-1, TFNbeta, IL-3

Explanation

Question 17 of 28

1

What is the role of NFKB?

Select one or more of the following:

  • To compete for binding of CD28 with CD80.

  • A link between PRR and transcription.

  • A mediator of acute inflammation

  • A anti inflammatory cytokine

Explanation

Question 18 of 28

1

What type of inflammasome responds to all bacterial stimuli and is the one we learnt?

Select one of the following:

  • NLRP3

  • NLRC4

  • NLRP1

  • AIM2

Explanation

Question 19 of 28

1

What is a danger signal?

Select one of the following:

  • A signal from a co-stimulatory receptor that is only expressed when in danger

  • A signal that indicates cell death e.g. crystal salts.

Explanation

Question 20 of 28

1

What are these proteins part of? Cardinal, Asc and caspase?

Select one of the following:

  • The inflammasome

  • MHCI

  • MHCII

  • TCR

Explanation

Question 21 of 28

1

Why is the inflammasome a target for medicine?

Select one of the following:

  • Because many auto-immune disease involve excessive inflammation

  • Because it causes poor immune response

Explanation

Question 22 of 28

1

What are adjuvants?

Select one of the following:

  • Killed pathogens used in vaccines.

  • Agents that boost the immune response by acting as danger signals

Explanation

Question 23 of 28

1

What is gout?

Select one or more of the following:

  • An auto immune disease?

  • The build up of uric acid crystals

  • Excessive inflammation due to signal 2 being activated

  • IL-1Ralpha used as an antagonist to treat

Explanation

Question 24 of 28

1

What is the name of this disorder? IL-1 and IL-18 are produced, mice with this deficiency for NLRP3 have poor inflammasome development. IL-18 is used in gut function to mediate gut repair

Select one of the following:

  • Inflammatory bowl disease

  • Addisons disease

  • Gout

Explanation

Question 25 of 28

1

What is an antigen?

Select one or more of the following:

  • Something a Tcells and Bcell receptors recognise

  • Broken down macromolecules specific to foreign organisms

  • Something that directly stimulates Tcells to become different subsets

  • Something that indicates self antigen

Explanation

Question 26 of 28

1

What is an immunogen and an epitote?

Select one of the following:

  • Immunogen - antigen that initiates immune system
    Epitote - part of the antigen that binds to TCR/BCR

  • Immunogen - part of the antigen that binds to TCR/BCR
    Epitote - antigen that initiates immune system

Explanation

Question 27 of 28

1

How many genes does the human genome have?

Select one of the following:

  • 15000

  • 25000

  • 17000

  • 27000

Explanation

Question 28 of 28

1

How many different Tcell and Bcell receptors do we have as humans?

Select one of the following:

  • 25000000

  • 3500000

Explanation

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