Anti Cancer Drugs

Question 1 of 20

Medal-premium 1

Which statement best reflects the log-kill model of tumour growth?

Select one of the following:

  • Growth fraction of a tumour is constant, therefore, you cannot lower the dose and you can't get to zero cells because you're always killing a certain percentage.

  • Growth fraction of a tumour is not constant, therefore, dosing will be influenced by whether the tumour is in the early or late stage of growth.

  • The log-kill model is probably more accurate than the Gompertizian model because the log-kill model takes cell resistance into account.

  • The log-kill model only applies to terminal cancers.

Question 2 of 20

Medal-premium 1

What are the four most common sites of metastasis?

Select one of the following:

  • Lung, liver, bone, and brain

  • Lung, liver, spleen, and bone

  • Liver, bone, lymph nodes, and spleen

  • Spleen, lymph nodes, brain, and colon

Question 3 of 20

Medal-premium 1

You are caring for a client with primary colon cancer. You read on his chart that he is T1, N1, M0. You know that the TNM staging system stands for:

Select one of the following:

  • tumour size, nodal involvement, and metastases

  • tumour size, nuclear (cell division rate), and metastases

  • toxicity, nodal involvement, and metastases

  • tumour size, nuclear differentiation, and metasteses

Question 4 of 20

Medal-premium 1

What are the two elements that are taken into account when grading a cancer?

Select one of the following:

  • How differentiated the cancer cells are (well differentiated = low grade) and how quickly cells are dividing (slower = low grade)

  • The size of the tumour and the nodal involvement (regional spread)

  • How quickly the cells are dividing and the nodal involvement

  • The degree of aggressiveness of the tumour and how rapidly the cells are dividing

Question 5 of 20

Medal-premium 1

You are caring for a 43-year-old premenopausal woman with metastatic breast cancer. Which of the following cytotoxic agents is going to be most important in her treatment plan?

Select one of the following:

  • Tamoxifen

  • Aromatase inhibitors

  • Corticosteroids

  • Vinca alkaloids

Question 6 of 20

Medal-premium 1

You are caring for a 58-year-old male patient with testicular carcinoma. He is prescribed Etoposide, which is an epipodophyllotoxin. This drug is...

Select one of the following:

  • A cell-cycle specific drug, meaning it does not affect cells in G0 (resting stage).

  • A cell-cycle non-specific drug, meaning it affects cells at all stages of cell growth cycle.

  • A drug that is only effective for slow growing tumours.

  • A drug that works by targeting specific antigens on the cell surface, thereby blocking cell signaling and making cells more visible to the immune system.

Question 7 of 20

Medal-premium 1

You are caring for a 30-year-old female patient diagnosed with Hodgkin's Lymphoma. She is prescribed Doxorubicin, which is an antitumour antibiotic. Which statement most accurately describes the action of this drug?

Select one of the following:

  • It is a cell cycle non-specific drug that binds with DNA and interferes with the action of topoisomerase II.

  • It is a cell cycle specific drug that binds with DNA and interferes with the action of topoisomerase II.

  • It is a cell cycle non-specific drug that interferes with DNA replication through binding and cross-linking.

  • It is a highly toxic biologic response modifier that is only approved for experimental use.

Question 8 of 20

Medal-premium 1

You are caring for a 72-year-old male with bladder cancer. He is being given adjuvant therapy of BCG vaccine. Which statement most accurately describes the BCG vaccine?

Select one of the following:

  • It is a biologic response modifier (immunostimulant) that is given as an in situ instillation.

  • It is an antitumor antibiotic that binds with DNA and interferes with the action of topoisomerase II.

  • It is an antimetabolite that is effective for high growth fraction tumours.

  • It is a targeted therapy that has a controversial risk-benefit profile.

Question 9 of 20

Medal-premium 1

Which of the following statements best describes monoclonal antibodies?

Select one of the following:

  • A type of targeted therapy that interacts with specific antigens on the cell surface to block cell signalling and make cells more visible to the immune system.

  • A type of targeted therapy that crosses the cell membrane and interferes with enzymatic activity of target proteins.

  • A type of cell cycle non-specific drug that interferes with DNA replication via binding and cross-linking.

  • A type of cell cycle non-specific drug that binds with DNA and interferes with the action of topoisomerase II.

Question 10 of 20

Medal-premium 1

You are caring for a 45-year-old female patient with breast cancer. She is prescribed Trastuzumab. Which statement best describes this drug?

Select one of the following:

  • It works against HER2 to inhibit cell proliferation and stimulate apoptosis. The main side effect is cardiotoxicity.

  • It works against HER2 to inhibit cell proliferation and stimulate apoptosis. The main side effect is increased risk of thrombosis.

  • It binds to VEGF (vascular endothelial growth factor) receptors to inhibit tumour growth. The main side effect is risk of hemorrhage.

  • It binds to VEGF (vascular endothelial growth factor) receptors to inhibit tumour growth. The main side effect is cardiotoxicity.

Question 11 of 20

Medal-premium 1

What is the main draw back of using monoclonal antibodies, such as Cetuximab, Trastuzumab, and Bevacizumab?

Select one of the following:

  • These drugs can only be administered via the parenteral route.

  • These drugs have a controversial risk/benefit profile and are highly toxic.

  • These drugs all decrease neutrophils and platelets.

  • These drugs all come with the risk of cardiotoxicity.

Question 12 of 20

Medal-premium 1

You are caring for a 64-year-old male with chronic myeloid leukemia (CML). Which of the following drugs will he mostly likely be taking?

Select one of the following:

  • Imatinib

  • Trastuzumab

  • Bevacizumab

  • Cetuximib

Question 13 of 20

Medal-premium 1

Which of the following is the main side effect of Imatinib (small molecule drug, targeted therapy)?

Select one of the following:

  • Neutropenia and thrombocytopenia

  • Cardiotoxicity

  • Increased risk of thrombosis

  • Interstitial lung disease

Question 14 of 20

Medal-premium 1

You are caring for a patient who is experiencing nausea two days after receiving chemotherapy. What therapy will be most effective for this patient?

Select one of the following:

  • Gravol

  • Lorazepam

  • Prochlorperazine

  • Pharmacologic treatment will be ineffective for this patient because this is a case of delayed nausea, which is very difficult to treat

Question 15 of 20

Medal-premium 1

A patient is experiencing severe nausea and vomiting 12 hours after chemotherapy. Which treatment will be most effective for this patient?

Select one of the following:

  • Dexamethasone

  • Lorazepam

  • Gravol

  • Ginger chews

Question 16 of 20

Medal-premium 1

You are caring for a 64-year-old male patient with chronic myeloid leukemia. He is receiving Imatinib (small molecule drug) as part of his treatment. He calls the cancer centre and reports a temperature of 38.5 degrees C and abdominal pain. What is the likely cause of his symptoms?

Select one of the following:

  • Febrile neutropenia

  • Anemia

  • Thrombocytopenia

  • Hyper-sensitivity reaction

Question 17 of 20

Medal-premium 1

You are caring for a patient who has developed febrile neutropenia (FNE) as a result of their cancer therapy. This patient asks you how this will impact their course of treatment going forward. What is the best response?

Select one of the following:

  • "This is a normal part of the treatment process. The neutropenia will resolve on it's own before your next round of chemotherapy."

  • "Your oncologist will discuss the next steps with you. She may recommend that we decrease the dose of your next round of chemotherapy. Or, if she decides that the dose will stay the same, she may suggest that you be given a drug called Filgrastim prior to your next round of chemotherapy to prevent you from developing FNE again."

  • "It is very important that you increase the amount of iron-rich foods you are eating so that your body can heal before the next round of chemotherapy."

  • "Unfortunately, febrile neutropenia is a common side effect of some drugs. Your physician will likely prescribe an antibiotic for you to prevent infection before your next round of chemotherapy."

Question 18 of 20

Medal-premium 1

Your patient has been prescribed prophylactic Filgrastim (g-CSF) before his next round of chemo. Your patient has forgotten what this drug is for. What is the most appropriate explanation that you can offer to your patient?

Select one of the following:

  • "Filgrastim is a drug used to prevent patients from developing febrile neutropenia, which is a condition that increases your risk of infection. It stimulates the production and release of certain cells (neutrophils) from your bone marrow. Therefore, a side effect of this drug is that you may experience some bone pain."

  • "Filgrastim is a drug that is given as an injection. It stimulates your bone marrow to produce red blood cells."

  • "You will have to phone your physician and ask him or her to explain to you again why you were prescribed that drug."

  • "Filgrastim will alter the way that the chemotherapy is metabolized in your body. It will prevent you from developing side effects, such as febrile neutropenia."

Question 19 of 20

Medal-premium 1

Your patient has developed anemia as a side effect of chemotherapy. Select all appropriate treatments:

Select one or more of the following:

  • rest

  • oxygen therapy

  • RBC transfusion

  • epoetin alpha

  • filgrastim

Question 20 of 20

Medal-premium 1

You are administering a drug via infusion. The patient calls you over to report that they feel aching and tightness around the IV site. You notice some red streaking. What should you do first?

Select one of the following:

  • Stop the infusion, leave needle in place, and aspirate

  • Stop the infusion, remove the needle, and monitor the patient closely

  • Immediately refer to the extravasation kit available in the clinic

  • Continue the infusion. This is a typical reaction to certain chemotherapies.

Icon_fullscreen

Anti Cancer Drugs

Ashling Ligate
Quiz by , created over 1 year ago

Quiz for anti cancer drugs.

Eye 161
Pin 1
Balloon-left 0
Tags
Ashling Ligate
Created by Ashling Ligate over 1 year ago
Close