Which of the following anticoagulants is used as an alternative in patient with HIT?
heparin
lmwh such as enoxaparin or dalteparin
warfarin
danaparoid
Explain how heparin is produced
True or False:
The MW of unfractionated heparin is between about 12000-16000Da
Treu or False
Heparin is a heterogeneous mix of glycosaminoglycans of variable length
How does heparin work?
True or False:
To inactivate thrombin, heparin must form a ternary complex binding both AT and thrombin and only UFH with >18 saccharide units can do this
By what routes do we administer heparin?
Which of the following statements is incorrect?
a. heparin is extensively bound to plasma proteins
b. onset of action of IV heparin is immediate
c. the half-life of UFH is independent of dose
How is heparin eliminated from body?
Does unfractionated heparin require close monitoring and periodic dose adjustment?
Why should a heparin formulation containing benzyl alcohol not be used in premature babies
Which of the following is used to flush cannula?
heparin 5000u/mL
heparinised normal saline (50U/5mL)
What drug is used to reverse the effect of heparin and how does it work?
What is an adverse effect that results in drop in platelet count that can occur with heparin?
Explain how LMWHs differ from heparin (UFH) - how are they made and in chemical structure how do they differ?
What are two examples of LMWHS?
How is the anticoagulant effect of LMWHs produced and how does it differ from heparin (UFH)?
Can dalteparin and enoxaparin be interchanged clinically (i.e. swap patients between these two LMWHs)?
What are the advantages of LMWHs over heparin (UFH)
Is the anticoagulant effect of LMWHS fully reversed by protamine sulphate?
True or False:
LMWHs supplied in prefilled syringe must have the bubble in syringe expelled before use
True or False
The needles on the LMWH profiled syringes should be wiped with a swab before injection
True or False:
Danaparoid is a low molecular weight heparin
