A low level of carbon dioxide labeled with 14C is accidentally released into the atmosphere surrounding industrial workers as they resume work following the lunch hour. Unknowingly, they breathe the contaminated air for 1 hour. Which of the following compounds will be radioactively labeled?
All of the carbon atoms of newly synthesized fatty acid.
About one half of the carbon atoms of newly synthesized fatty acids.
The carboxyl atom of newly synthesized fatty acids.
About one third of the carbons of newly synthesized malonyl CoA.
One half of the carbon atoms of newly synthesized acetyl CoA.
A teenager, concerned about his weight, attempts to maintain a fat-free diet for a period of several weeks. If his ability to synthesize various lipids were examined, he would be found to be most deficient in his ability to synthesize:
A 44-year-old man displayed elevated cholesterol levels and was prescribed a statin to reduce such levels. Statin treatment has the potential to interfere with the synthesis of which of the following?
A 12-year-old female presented with severe abdominal pain and was found to have a markedly elevated plasma triglyceride concentration (750 mg/dL). A lipoprotein analysis revealed elevated levels of chylomicrons and VLDL and reduced levels of HDL. Which protein might be defective in this patient?
Statins are ineffective in lowering cholesterol levels in individuals with homozygous familial hypercholesterolemia due to which of the following?
HMG-CoA reductase is resistant to statins
Statins cannot enter the liver cells
LDL receptors are nonfunctional
Reverse cholesterol transport is inoperative in these patients
LCAT is resistant to statin action
An adult male should have HDL levels equal to or greater than 40 mg/dL. A necessary enzyme contributing to HDL’s protective effect is which of the following?
AMP-activated protein kinase
Protein kinase A
You have placed a patient on Pravachol pravastatin to reduce her cholesterol. This class of drugs is effective due to a direct inhibition of which of the following?
Carnitine acyltransferase 1 (CAT-1)
A child has been diagnosed with Tay–Sachs disease, in which a particular lipid accumulates within the lysosomes. The component of this lipid which cannot be removed in the lysosome is which of the following?
Glutathione is a constituent of
None of these
Cyclo-oxygenase is involved in the synthesis of
Prostaglandin and thromboxane
Esters of fatty acids with higher alcohols other than glycerol are said to be
Carnitine is synthesized from
A patient has been diagnosed with abetalipoproteinemia. A possible deficiency in which of the following vitamins could occur in this patient?
Which one of the fatty acids listed below can be synthesized by humans?
Cis Δ9, 12 C18:2
Cis Δ9, 12, 15 C18:3
Cis Δ5, 8, 13 C20:3
Cis Δ5, 8, 11, 14 C20:4
Cis Δ10 C16:1
You are treating a patient with a fat malabsorption problem, and you suggest that the patient switch his or her diet to one that contains which of the following?
Triglycerides with long-chain fatty acids
Triglycerides with medium-chain fatty acids
Triglycerides with short-chain fatty acids
Triglycerides with a mixture of long-chain and short-chain fatty acids
Triglycerides with a mixture of long-chain and medium-chain fatty acids
Treatment of dyslipidemia may involve giving the patient one of these
The above prescription works by
Lowering serum LDL levels
Lowering levels of VLDL and raises levels of HDL
Raising LDL levels
Increasing bile acids synthesis
Inhibiting HMG CoA reductase activity
The exchange of cholestrol esters for triacylglycerols between HDLs and VLDLs is catalysed by
Tay-Sachs is to hexosaminidase as Gaucher is to__________
Non-liver and Non-intestine cells get cholesterol from the plasma, rather than synthesizing it de novo from LDL