BIOCHEMISTRY: Intermediate metabolism

Question 1 of 20

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A low level of carbon dioxide labeled with 14C is accidentally released into the atmosphere surrounding industrial workers as they resume work following the lunch hour. Unknowingly, they breathe the contaminated air for 1 hour. Which of the following compounds will be radioactively labeled?

Select one of the following:

  • All of the carbon atoms of newly synthesized fatty acid.

  • About one half of the carbon atoms of newly synthesized fatty acids.

  • The carboxyl atom of newly synthesized fatty acids.

  • About one third of the carbons of newly synthesized malonyl CoA.

  • One half of the carbon atoms of newly synthesized acetyl CoA.

Question 2 of 20

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A teenager, concerned about his weight, attempts to maintain a fat-free diet for a period of several weeks. If his ability to synthesize various lipids were examined, he would be found to be most deficient in his ability to synthesize:

Select one of the following:

  • Triacylglycerol

  • Phospholipids

  • Cholesterol

  • Sphingolipids

  • Prostaglandins

Question 3 of 20

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A 44-year-old man displayed elevated cholesterol levels and was prescribed a statin to reduce such levels. Statin treatment has the potential to interfere with the synthesis of which of the following?

Select one of the following:

  • Heme

  • Dihydrobiopterin

  • Ketone bodies

  • Coenzyme Q

  • Glycogen

Question 4 of 20

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A 12-year-old female presented with severe abdominal pain and was found to have a markedly elevated plasma triglyceride concentration (750 mg/dL). A lipoprotein analysis revealed elevated levels of chylomicrons and VLDL and reduced levels of HDL. Which protein might be defective in this patient?

Select one of the following:

  • ApoCII

  • ApoB100

  • ApoE

  • Pancreatic lipase

  • LCAT

Question 5 of 20

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Statins are ineffective in lowering cholesterol levels in individuals with homozygous familial hypercholesterolemia due to which of the following?

Select one of the following:

  • HMG-CoA reductase is resistant to statins

  • Statins cannot enter the liver cells

  • LDL receptors are nonfunctional

  • Reverse cholesterol transport is inoperative in these patients

  • LCAT is resistant to statin action

Question 6 of 20

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An adult male should have HDL levels equal to or greater than 40 mg/dL. A necessary enzyme contributing to HDL’s protective effect is which of the following?

Select one of the following:

  • CETP

  • LCAT

  • ACAT

  • AMP-activated protein kinase

  • Protein kinase A

Question 7 of 20

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You have placed a patient on Pravachol pravastatin to reduce her cholesterol. This class of drugs is effective due to a direct inhibition of which of the following?

Select one of the following:

  • HMG-CoA synthase

  • HMG-CoA reductase

  • Carnitine acyltransferase 1 (CAT-1)

  • Citrate lyase

Question 8 of 20

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A child has been diagnosed with Tay–Sachs disease, in which a particular lipid accumulates within the lysosomes. The component of this lipid which cannot be removed in the lysosome is which of the following?

Select one of the following:

  • Sphingomyelin

  • Ceramide

  • Fatty acid

  • Glucose

  • N-acetylgalactosamine

Question 9 of 20

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Glutathione is a constituent of

Select one of the following:

  • Leukotriene A4

  • Leukotriene C4

  • Thromboxane A1

  • None of these

Question 10 of 20

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Cyclo-oxygenase is involved in the synthesis of

Select one of the following:

  • Prostaglandin

  • Thromboxane

  • Prostaglandin and thromboxane

  • Leukotriene

Question 11 of 20

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Esters of fatty acids with higher alcohols other than glycerol are said to be

Select one of the following:

  • Waxes

  • Fats

  • None of these

  • Oils

Question 12 of 20

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Carnitine is synthesized from

Select one of the following:

  • Lysine

  • Serine

  • Choline

  • Arginine

Question 13 of 20

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A patient has been diagnosed with abetalipoproteinemia. A possible deficiency in which of the following vitamins could occur in this patient?

Select one of the following:

  • Vitamin B1

  • Vitamin B2

  • Niacin

  • Vitamin C

  • Vitamin E

Question 14 of 20

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Which one of the fatty acids listed below can be synthesized by humans?

Select one of the following:

  • Cis Δ9, 12 C18:2

  • Cis Δ9, 12, 15 C18:3

  • Cis Δ5, 8, 13 C20:3

  • Cis Δ5, 8, 11, 14 C20:4

  • Cis Δ10 C16:1

Question 15 of 20

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You are treating a patient with a fat malabsorption problem, and you suggest that the patient switch his or her diet to one that contains which of the following?

Select one of the following:

  • Triglycerides with long-chain fatty acids

  • Triglycerides with medium-chain fatty acids

  • Triglycerides with short-chain fatty acids

  • Triglycerides with a mixture of long-chain and short-chain fatty acids

  • Triglycerides with a mixture of long-chain and medium-chain fatty acids

Question 16 of 20

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Treatment of dyslipidemia may involve giving the patient one of these

Select one of the following:

  • Niacin

  • Lovastatin

  • Vitamin E

  • Mevastatin

Question 17 of 20

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The above prescription works by

Select one of the following:

  • Lowering serum LDL levels

  • Lowering levels of VLDL and raises levels of HDL

  • Raising LDL levels

  • Increasing bile acids synthesis

  • Inhibiting HMG CoA reductase activity

Question 18 of 20

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The exchange of cholestrol esters for triacylglycerols between HDLs and VLDLs is catalysed by

Select one of the following:

  • LCAT

  • CETP

  • ACAT

  • Lipoprotein lipase

Question 19 of 20

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Tay-Sachs is to hexosaminidase as Gaucher is to__________

Select one of the following:

  • Glucocerebrosidase

  • Sphingomyelinase

  • Alpha-galactosidase

  • Arylsulphatase A

Question 20 of 20

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Non-liver and Non-intestine cells get cholesterol from the plasma, rather than synthesizing it de novo from LDL

Select one of the following:

  • True
  • False
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BIOCHEMISTRY: Intermediate metabolism

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