Loss of WT-1 gene results in what cancer?
All of the following are Autosomal recessive cancer predisposition disorders except?
Xeroderma Pigmentosum (XP)
Breast cancer associated with BRCA2
All of the following are features of fanconi anemia except
Pancytopenia (bone marrow failure)
Risk of AML
Upper limb skeletal abnormalities
DNA repair defect
none of the above
Glioblastoma multiforme is due to 100x expression of an miRNA true or false?
Translocation in Burkitt's lymphoma
All of the following are true statements except
Kaposis sarcoma caused by HHV-8
Non-Hodgkin lymphoma - EBV
Cervical cancer - HPV
T-Cell leukemia - HTLV-I retrovirus
CML - HPV
HPV oncogenes E6 & E7 act by?
inactivating p53 thereby activating cell proliferation
activating P21 Transciption
In which cells telomeres are renewed (by activation of telomerase)?
all of the above
None of the above
Replicative senescence is due to the absence of telomerase - true or false
TERC : reverse transcriptase and TERT : RNA template true or false
Upregulation of what gene upregulates telomerase
Telomerase reactivation in cancer is the initiating event true or false
Telomerase reactivation in cancer is an important step in cancer progression true or false
Which of the following receptors belong to RTK family (receptor tyrosine kinases)
Activated RTKs phosphorylate what effector proteins?
both PLC PI3K
RTK activation -> reveals docking site for adapter protein GRB2 -> binds to SOS (RAS GEF) --> activates RAS -> activates MAPK --> activates TFs ( FOS, JUN, MYC) true or false
Her2/EGFR2 genes are amplified in 30% breast cancers true or false
RAS-Gap gene codes for neurofibromin (NF1) true or false
Estrogen receptor = Transcription factor which binds to estrogen response element enhancing transcription of cyclin D true or false
Tamoxifen is an estrogen receptor antagonist true or false
Prostate cancer occurs in the transition zone and BPH occurs primarily in the peripheral zone true or false
Flutamide and bicalutamide are androgen receptor antagonists true or false