Neuro Pharmacology - Seizures & Movement Disorders

Question 1 of 21

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An abnormal, excessive or synchronous firing of populations of brain neurons. These are transient and often reversible

Select one of the following:

  • True
  • False

Question 2 of 21

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Seizures are a manifestation of an imbalance between the excitatory and inhibitory pathways in the brain. Which of the following statements about seizures is incorrect

Select one of the following:

  • Excitation is due to excessive firing of glutamaterigic neurons.

  • Inhibition of GABAergic neurons can be an effect therapy for the treatment of seizures.

  • Defective inhibition of excitatory firing is major cause of seizures

Question 3 of 21

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At what region of the brain does the corticospinal tract decussate?

Select one of the following:

  • Midbrain

  • Medulla

  • Pons

  • Brain Stem

Question 4 of 21

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Na+ Channel Blockers stabilize channel in their closed, resting state making the activity of the drug activity dependent

Select one of the following:

  • True
  • False

Question 5 of 21

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Select all of the statements that are true regarding anti-epileptic drug Phenytoin.

Select one or more of the following:

  • It is the first line drug for the treatment of partial seizures.

  • Phenytoin is NOT indicated for use in absence seizures.

  • It increases the recovery of voltage-gated Na+ channels from inactivation

  • A potential side effect of phenytoin is hirsutism

Question 6 of 21

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Select the response that is incorrect regarding anti-epileptic drugs

Select one of the following:

  • Carbamazepine is contraindicated in the case of absence seizures

  • Valproic acid is safe effective against most partial and generalized seizures inlcuding absence seizures

  • Because of it's causes an increase in liver enzymes, valproic acid is contraindicated in children < 2 years old.

  • Anti-Epileptics that block Ca2+ (L,N) channels are effective in the treatment of absence seizures

Question 7 of 21

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The first line treatment for infantile spasms is ACTH or prednisone

Select one of the following:

  • True
  • False

Question 8 of 21

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Which statements below describe the importance of the neurotransmitter dopamine?

Select one or more of the following:

  • Dopamine has a significant role in learning, motor control, goal-directed behavior, and the regulation of hormones.

  • Tyrosine hydroxylase converts Tyrosine to DOPA which is rapidly converted to dopamine by DOPA decarboxylase.

  • Activation of dopamine D1-like receptors inhibits adenylyl cyclase leading to a decrease in the concentration of cAMP

  • Dopamine belongs to the catecholamine family

Question 9 of 21

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D2 receptors play a key role in schizophrenia and extrapyramidal movement

Select one of the following:

  • True
  • False

Question 10 of 21

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D4 receptors are implicated in addictive behavior.

Select one of the following:

  • True
  • False

Question 11 of 21

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Which of the following statements about dopaminergic pathways are correct?

Select one or more of the following:

  • The mesolimbic pathway is associated with motivational emotional responses

  • The mesocortical ( a part of the basal ganglia motor loop) is associated with coordination of movement

  • The tuberoinfundibulnar pathway regulates the secretion of prolactin by pituitary gland and is involved in maternal behavior

  • The mesolimbic pathway is associated with pleasure, reward, and goal-directed behavior.

Question 12 of 21

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Dopamine receptors adenylyl cyclase leading to a in the concentration of cAMP. Dopamine D1-like receptors adenylyl cyclase leading to an in the concentration of cAMP. receptors are implicated in addiction. receptors play a key role in the pathogenesis of schizophrenia and extrapyramidal symptoms. receptors are implicated in impulse control and mania.

Drag and drop to complete the text.

    D2-like
    D2-like
    cAMP
    cAMP
    D1-like
    D1-like
    D1,D5
    D1,D5
    Impulse
    Impulse
    adenylyl cyclase
    adenylyl cyclase
    dopamine
    dopamine
    inhibit
    inhibit
    decrease
    decrease
    synthesize
    synthesize
    hydroxylate
    hydroxylate
    regulation
    regulation
    D2
    D2
    D1
    D1
    D6
    D6
    D4
    D4
    D3
    D3
    D5
    D5
    inhibitory
    inhibitory
    lower
    lower
    activated
    activated
    increase
    increase

Question 13 of 21

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A patient present with an EEG showing a increased activity in a small group of neurons in the left motor cortex. Which of the following statements about the presentation of this seizure is FALSE?

Select one of the following:

  • The patient would have convulsions on the left side of the body

  • The patient will remember the seizure

  • The patient will benefit from glutaminergic potentiators

  • None of the above

Question 14 of 21

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An epileptic patient is in your office and loses consciousness for a brief period of time (5-10 seconds). Luckily they were hooked up to an EEG machine which documented the encounter. You see a a distinctive spike-and-wave pattern. Which statement(s) below are true?

Select one of the following:

  • This patient may have symmetrical fluttering of the eye lids during the episode

  • Low Ca2+ current in the thalamus would be discovered upon further study

  • This patient is experiencing an absence seizure

  • This patient very likely was accused of daydreaming as a child.

  • All of the above

Question 15 of 21

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The body uses SODIUM channels to overcome the synchronous firing of neurons in GENERALIZED TONIC-CLONIC Seizures.

Select one of the following:

  • True
  • False

Question 16 of 21

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Which statement about infantile spasms is FALSE?

Select one of the following:

  • These can lead to permanent cognitive delay/deficit

  • They present with sudden, repetitive, myoclonic jerks

  • Fragmentary, bilateral attacks

  • Sudden "drop attacks" with some partial seziure activity

Question 17 of 21

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You have a 6 year old currently recurrent periods (5-10 seconds) where they appear to daze off then come back to attention. The EEG monitory shows a distinctive spike-and-wave pattern in all regions of the brain. Which drug would be the most appropriate to treat this child's condition?

Select one of the following:

  • Phenobarbital

  • Valproic Acid

  • Ethosuximide

  • Phenytoin

Question 18 of 21

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Which clinical manifestations of patients suffering from Parkinson's disease is FALSE?

Select one of the following:

  • Micrograhia

  • Tightness/Stiffness of Muscles

  • Tremors that decrease with deliberate movements

  • Decrease muscle tone/strength

Question 19 of 21

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Parkinson's Plus Syndromes

Select one of the following:

  • Present with multiple system atrophy

  • Display with marked orthostatic hypotension

  • Respond very poorly to therapy, thus have a worse prognosis than idiopathic PD

  • Patients typically have an abnormally wide gait

  • All of the above

Question 20 of 21

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Which statement about cholinergic drugs is FALSE?

Select one of the following:

  • The highest content of ACh in the brain is located in the striatum

  • ACH release in inhibited by dopamine

  • Cholinergic activity due to lack of dopamine is responsible to bradykinesia.

  • Anticholinergics side effects include dry mouth, blurry vision, constipation

Question 21 of 21

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Ballismus

Select one of the following:

  • Usually occur younger patients

  • Treatment with anti-psychotics is ineffective

  • Movement is typically contralateral

  • Can occur due to lesions of the contralateral subthalamic nucleus

  • None of the above

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Neuro Pharmacology - Seizures & Movement Disorders

Ifeoma Okekearu
Quiz by , created about 1 year ago

Quiz/Exam for KU SOP Pharmacology III Exam I

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Ifeoma Okekearu
Created by Ifeoma Okekearu about 1 year ago
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