chris.kingsnorth
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A short MCQ on cystic fibrosis

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Cystic Fibrosis

Cystic Fibrosis

Question 1 of 13

1

How many children are affected by CF in the UK?

Select one of the following:

  • 1 in 25,000

  • 1 in 2500

  • 1 in 250

  • 1 in 250,000

Explanation

Question 2 of 13

1

How many people are carriers of CF in the UK?

Select one of the following:

  • 1 in 25

  • 1 in 250

  • 1 in 25,000

  • 1 in 250,000

Explanation

Question 3 of 13

1

Inheritance of CF is autosomal dominant

Select one of the following:

  • True
  • False

Explanation

Question 4 of 13

1

∆F508 is the most common CF mutation

Select one of the following:

  • True
  • False

Explanation

Question 5 of 13

1

The defective protein in CF is called:

Select one of the following:

  • CFTR

  • CTFR

  • CRTF

Explanation

Question 6 of 13

1

In the most common mutation of CFTR, the protein can escape the ER but once in the cell membrane dose not function properly

Select one of the following:

  • True
  • False

Explanation

Question 7 of 13

1

Positive Guthrie testing for CF is diagnostic of the condition

Select one of the following:

  • True
  • False

Explanation

Question 8 of 13

1

Low Na concentration in sweat on sweat test suggests CF

Select one of the following:

  • True
  • False

Explanation

Question 9 of 13

1

Growth of patients with CF is unaffected

Select one of the following:

  • True
  • False

Explanation

Question 10 of 13

1

Clinical features of CF are similar in all patients

Select one of the following:

  • True
  • False

Explanation

Question 11 of 13

1

Which of the following medications are not used in treatment of CF?

Select one of the following:

  • Bronchodilators (e.g. salmeterol)

  • Anticholinergics (e.g. ipratropium)

  • Antibiotics

  • Steroids

  • Mucolytics (e.g. DNase)

  • Beta-blockers

Explanation

Question 12 of 13

1

CFTR modulators are currently the mainstay of treatment for CF in the UK

Select one of the following:

  • True
  • False

Explanation

Question 13 of 13

1

Median survival in CF is currently estimated at:

Select one of the following:

  • 31 years

  • 41 years

  • 51 years

  • 61 years

Explanation

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