Choose the correct macromolecular inhibitor involved in enzyme regulation?
Protease Inhibitors
Elastase Inhibitors
Amylase Inhibitors
Where do Serpins reside in the body?
Lymph
Blood
Brain
What processes are Serpins involved in?
Growth and Development
Coagulation and Inflammation
Cellular Differentiation
What type of complex do Serpins form with target Proteases?
Ionic Complex
Hydrophobic Complex
Covalent Complex
What type of conformational change do Serpins undergo?
Stressed to Relaxed transition
Breaking of Covalent Bonds
Hydrogen Bond formation
What type of bond is formed between the Enzyme-Substrate complex following nucleophilic attack of Serine on the peptide bond of the substrate?
Hydrogen Bond
Ester Bond
Covalent Bond
What is formed following ester bond formation on the substrate-enzyme complex?
Acyl Enzyme Intermediate
Enzyme-Substrate Complex
Serpin-Protease complex
Hydrolysis of the acyl enzyme intermediate occurs at a __________ rate?
Fast
Slow
What happens when the serpin is attached to the protease?
The Serpin is Consumed
The Serpin is Reused
The Serpin is Hydrolysed