Choose the correct macromolecular inhibitor involved in enzyme regulation?
Where do Serpins reside in the body?
What processes are Serpins involved in?
Growth and Development
Coagulation and Inflammation
What type of complex do Serpins form with target Proteases?
What type of conformational change do Serpins undergo?
Stressed to Relaxed transition
Breaking of Covalent Bonds
Hydrogen Bond formation
What type of bond is formed between the Enzyme-Substrate complex following nucleophilic attack of Serine on the peptide bond of the substrate?
What is formed following ester bond formation on the substrate-enzyme complex?
Acyl Enzyme Intermediate
Hydrolysis of the acyl enzyme intermediate occurs at a __________ rate?
What happens when the serpin is attached to the protease?
The Serpin is Consumed
The Serpin is Reused
The Serpin is Hydrolysed