Integral Membrane Proteins

Question 1 of 31

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5% of the human genome is genes that add a phosphate to something using ATP (Kinases)

Select one of the following:

  • True
  • False

Question 2 of 31

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Which of the following residues can be phosphorylated by kinases?

Select one or more of the following:

  • Serine

  • Threonine

  • Tyrosine

  • Valine

  • Argenine

  • Glutamic Acid

Question 3 of 31

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How many different kinases are there (roughly)?

Select one of the following:

  • 510

  • 520

  • 530

Question 4 of 31

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In kinases, DFG & RC motifs are highly conserved

Select one of the following:

  • True
  • False

Question 5 of 31

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Which domains are commonly found in kinase interacting proteins?

Select one or more of the following:

  • SH1

  • SH2

  • SH3

Question 6 of 31

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SH3 proteins mediate the assembly of proteins structures by binding to proline rich peptides in them

Select one of the following:

  • True
  • False

Question 7 of 31

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SH domains modulate protein interactions by recognizing and binding to specific proteins by identifying specific peptide sequences

Select one of the following:

  • True
  • False

Question 8 of 31

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What is the role of PH domains?

Select one of the following:

  • Binding the protein to the ER membrane

  • Binding the protein to the cell membrane

  • Binding the protein to nuclear membrane

Question 9 of 31

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Membranes form what?

Select one of the following:

  • Compartments & permeability barriers

  • Compartments & osmotic barriers

Question 10 of 31

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What mediate membrane functions?

Select one of the following:

  • Proteins

  • Glycolipids

  • Phospholipid concentration

Question 11 of 31

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Mitochondiral membranes contail the most proteins, plasma membranes contain the least (Out of Mitochondrial, Plasma and Myelin membranes)

Select one of the following:

  • True
  • False

Question 12 of 31

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Most integral membrane proteins span the membrane

Select one of the following:

  • True
  • False

Question 13 of 31

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Integral proteins interact extensively with what?

Select one of the following:

  • The hydrocarbon chains of lipids

  • The phosphate groups of phospholipids

  • The hydrocarbon tails of phospholipids

Question 14 of 31

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Peripheral proteins are bound to the membrane via the head groups of phospholipids

Select one of the following:

  • True
  • False

Question 15 of 31

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How do we tell how strongly a membrane protein is associated?

Select one of the following:

  • Try and disassociate it using detergent

  • Try and disassociate it using water

Question 16 of 31

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Baterial Rhodopsin uses heat to pump protons out of the membrane

Select one of the following:

  • True
  • False

Question 17 of 31

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How is the hydrophobic core formed in baterorhodopsin?

Select one of the following:

  • 7 alpha helices

  • 7 beta sheets

  • 3 alpha helices, 4 beta sheets

Question 18 of 31

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In the case of the highly conserved 'Membrane Spanning Alpha Helix Structure', what must be on the outside?

Select one of the following:

  • Phospholipids

  • Non-polar aa

  • Polar aa

Question 19 of 31

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The membrane spanning alpha helix structure acts as what?

Select one of the following:

  • A scaffold for the active site

  • The active site

  • The channel for the active site to move through

Question 20 of 31

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Transmembrane helices can be predicted by a long string (or more) of hydrophobic amino acids in their aa sequence

Select one of the following:

  • True
  • False

Question 21 of 31

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What is used to estimate the free energy change of a residue on transfer of a residue to water (i.e. how much energy does it take to disassociate the aa from the protein)?

Select one of the following:

  • A polarity scale

  • An amino scale

  • A pH scale

Question 22 of 31

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An amino acid with high energy lies buried in a hydrophobic region i.e. the membrane

Select one of the following:

  • True
  • False

Question 23 of 31

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How large is the hydrocarbon core of the membrane?

Select one of the following:

  • 30A

  • 32A

  • 34A

Question 24 of 31

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What is the name of the 20aa section of an integral protein that spans the membrane?

Select one of the following:

  • Pocket

  • Window

  • Scaffold

Question 25 of 31

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How is a Hydropathy plot formed?

Select one of the following:

  • The free energy change for each 20 aa segement plotted against the first aa in each segment

  • The free energy change for each 20 aa segement plotted against the last aa in each segment

  • The free energy change for each 30 aa segement plotted against the first aa in each segment

Question 26 of 31

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What is the point of a hydropathy plot?

Select one of the following:

  • To find which aa are in hydrophobic areas

  • To find the window of integral proteins

  • To find the window of peripheral proteins

Question 27 of 31

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The criterion level for a hydropathy plot is +68

Select one of the following:

  • True
  • False

Question 28 of 31

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What is Porin an example of?

Select one of the following:

  • Membrane spanning alpha helices

  • Membrane spanning beta sheets

  • Membrane spanning helix/beta sheet structure

Question 29 of 31

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What tends to be the features of membrane spanning beta sheet residues?

Select one of the following:

  • Hydrophobic

  • Hydrophillic

  • Alternating hydrophobic and hydrophilic

Question 30 of 31

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The polarity of the internal aa in a membrane spanning beta sheet depends on the size

Select one of the following:

  • True
  • False

Question 31 of 31

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Each sheet in the m.s beta sheet arrangement is hydrogen bonded to its neighbor in a parallel manner

Select one of the following:

  • True
  • False
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Integral Membrane Proteins

gina_evans0312
Quiz by , created almost 3 years ago

Structural Basis for Biological Function (Membrane Proteins) Quiz on Integral Membrane Proteins, created by gina_evans0312 on 14/12/2013.

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gina_evans0312
Created by gina_evans0312 almost 3 years ago
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