Which of the following can cause double strand breaks in the DNA?
DNA replication errors
What are Chromosome Fragile Sites?
Sites where double strand breaks are likely to occur
Sites that can be easily split accidentally by protein machinery
Sites that are likely to warp during heat shock
Chromosome fragile sites are thought to be caused by difficulties during meiosis
What does NHEJ stand for?
Non-homologous end joining
Non-homologous editing joints
Non-heterodimeric end joints
What are the requirements for NHEJ?
Double strand breaks
Single strand breaks
DNA ligase 4
DNA ligase 2
The repair process of NHEJ will join any 2 free ends together, regardless of homology
An error in NHEJ can lead to translocation between which chromosomes, forming what type of chromosome fusion?
9 & 22
13 & 21
The repair process of Homologous Recombination relies on what?
That the damaged sequence in the sister chromatid is intact
That the damaged sequence in the homologous chromosome is intact
That the damaged sequence in the other allele is intact
What is required for an error in Homologous Recombination?
A faulty alignment of the two chromosomes
A faulty alignment of the two chromatids
Due to inversions
Due to translocations
Due to repeats
What type of repair is the image showing?
A fault in Homologus Recombination can lead to alleles being lost